Tang XC

General

Full name : Tang Xi Can

First name : Xi Can

Mail : State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai

Zip Code :

City :

Country : China

Email : xctang@mail.shcnc.ac.cn

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References (61)

Title : Rivastigmine Transdermal Patch Treatment for Moderate to Severe Cognitive Impairment in Veterans with Traumatic Brain Injury (RiVET Study): A Randomized Clinical Trial - Brawman-Mintzer_2021_J.Neurotrauma__
Author(s) : Brawman-Mintzer O , Tang XC , Bizien M , Harvey PD , Horner MD , Arciniegas DB , Raskind M , Johnson-Greene L , Martineau RJ , Hamner M , Rodriguez-Suarez M , Jorge RE , McGarity S , Wortzel HS , Wei Y , Sindowski T , Mintzer J , Kindy AZ , Donovan K , Reda D
Ref : Journal of Neurotrauma , : , 2021
PubMedID: 33514274

Title : A mouse model for MERS coronavirus-induced acute respiratory distress syndrome - Cockrell_2016_Nat.Microbiol_2_16226
Author(s) : Cockrell AS , Yount BL , Scobey T , Jensen K , Douglas M , Beall A , Tang XC , Marasco WA , Heise MT , Baric RS
Ref : Nat Microbiol , 2 :16226 , 2016
PubMedID: 27892925

Title : Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons - Tao_2016_Acta.Pharmacol.Sin_37_1391
Author(s) : Tao LX , Huang XT , Chen YT , Tang XC , Zhang HY
Ref : Acta Pharmacol Sin , 37 :1391 , 2016
PubMedID: 27498774

Title : Donepezil attenuates Abeta-associated mitochondrial dysfunction and reduces mitochondrial Abeta accumulation in vivo and in vitro - Ye_2015_Neuropharmacol_95_29
Author(s) : Ye CY , Lei Y , Tang XC , Zhang HY
Ref : Neuropharmacology , 95 :29 , 2015
PubMedID: 25744714

Title : Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution - Tang_2014_Proc.Natl.Acad.Sci.U.S.A_111_E2018
Author(s) : Tang XC , Agnihothram SS , Jiao Y , Stanhope J , Graham RL , Peterson EC , Avnir Y , Tallarico AS , Sheehan J , Zhu Q , Baric RS , Marasco WA
Ref : Proc Natl Acad Sci U S A , 111 :E2018 , 2014
PubMedID: 24778221

Title : Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe\/PS1dE9 transgenic mice - Wang_2012_J.Neurosci.Res_90_508
Author(s) : Wang Y , Tang XC , Zhang HY
Ref : Journal of Neuroscience Research , 90 :508 , 2012
PubMedID: 22002568

Title : Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion - Wang_2010_J.Neurosci.Res_88_807
Author(s) : Wang J , Zhang HY , Tang XC
Ref : Journal of Neuroscience Research , 88 :807 , 2010
PubMedID: 19795377

Title : Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors - Shi_2009_Acta.Pharmacol.Sin_30_1195
Author(s) : Shi YF , Zhang HY , Wang W , Fu Y , Xia Y , Tang XC , Bai DL , He XC
Ref : Acta Pharmacol Sin , 30 :1195 , 2009
PubMedID: 19578388

Title : Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia - Zhang_2008_Chem.Biol.Interact_175_396
Author(s) : Zhang HY , Zheng CY , Yan H , Wang ZF , Tang LL , Gao X , Tang XC
Ref : Chemico-Biological Interactions , 175 :396 , 2008
PubMedID: 18565502

Title : Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase - Zhang_2008_Cell.Mol.Neurobiol_28_173
Author(s) : Zhang HY , Yan H , Tang XC
Ref : Cellular Molecular Neurobiology , 28 :173 , 2008
PubMedID: 17657601

Title : Pharmacodynamic study of FS-0311: a novel highly potent, selective acetylcholinesterase inhibitor - Wang_2008_Cell.Mol.Neurobiol_28_245
Author(s) : Wang ZF , Yan J , Fu Y , Tang XC , Feng S , He XC , Bai DL
Ref : Cellular Molecular Neurobiology , 28 :245 , 2008
PubMedID: 17786550

Title : Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia - Wang_2008_J.Neurochem_106_1594
Author(s) : Wang ZF , Wang J , Zhang HY , Tang XC
Ref : Journal of Neurochemistry , 106 :1594 , 2008
PubMedID: 18513368

Title : Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury - Wang_2007_FEBS.Lett_581_596
Author(s) : Wang ZF , Tang XC
Ref : FEBS Letters , 581 :596 , 2007
PubMedID: 17257593

Title : Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B - He_2007_Bioorg.Med.Chem_15_1394
Author(s) : He XC , Feng S , Wang ZF , Shi Y , Zheng S , Xia Y , Jiang H , Tang XC , Bai D
Ref : Bioorganic & Medicinal Chemistry , 15 :1394 , 2007
PubMedID: 17126020

Title : Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha - Yan_2007_Neuroreport_18_689
Author(s) : Yan H , Zhang HY , Tang XC
Ref : Neuroreport , 18 :689 , 2007
PubMedID: 17426600

Title : Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism - Gao_2006_J.Neurosci.Res_83_1048
Author(s) : Gao X , Tang XC
Ref : Journal of Neuroscience Research , 83 :1048 , 2006
PubMedID: 16493671

Title : Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine - Wang_2006_Acta.Pharmacol.Sin_27_1
Author(s) : Wang R , Yan H , Tang XC
Ref : Acta Pharmacol Sin , 27 :1 , 2006
PubMedID: 16364207

Title : Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats - Liang_2006_Acta.Pharmacol.Sin_27_1127
Author(s) : Liang YQ , Tang XC
Ref : Acta Pharmacol Sin , 27 :1127 , 2006
PubMedID: 16923332

Title : Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease - Zhang_2006_Trends.Pharmacol.Sci_27_619
Author(s) : Zhang HY , Tang XC
Ref : Trends in Pharmacological Sciences , 27 :619 , 2006
PubMedID: 17056129

Title : Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease - Wang_2005_Neurosignals_14_71
Author(s) : Wang R , Tang XC
Ref : Neurosignals , 14 :71 , 2005
PubMedID: 15956816

Title : Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production - Tang_2005_Eur.J.Pharmacol_519_9
Author(s) : Tang LL , Wang R , Tang XC
Ref : European Journal of Pharmacology , 519 :9 , 2005
PubMedID: 16111675

Title : Poster (79) X-ray structures of TcAChE complexed with (+)-huperzine a and (-)-huperzine b: structural evidence for an active-site rearrangement -
Author(s) : Dvir H , Jiang H , Wong DM , Harel M , Chetrit M , He XC , Jin GY , Yu GL , Tang XC , Silman I , Bai DL , Sussman JL
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :362 , 2004
PubMedID:

Title : Neuroprotective effects of huperzine A and donepezil on staurosporine-induced injury in primary cortical neurons. -
Author(s) : Zhang HY , Tang XC
Ref : Cholinergic Mechanisms, CRC Press :751 , 2004
PubMedID:

Title : Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats - Liang_2004_Neurosci.Lett_361_56
Author(s) : Liang YQ , Tang XC
Ref : Neuroscience Letters , 361 :56 , 2004
PubMedID: 15135892

Title : Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells - Zhang_2003_Acta.Pharmacol.Sin_24_853
Author(s) : Zhang HY , Brimijoin S , Tang XC
Ref : Acta Pharmacol Sin , 24 :853 , 2003
PubMedID: 12956931

Title : [Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats] - Wang_2003_Zhonghua.Er.Ke.Za.Zhi_41_42
Author(s) : Wang LS , Zhou J , Shao XM , Tang XC
Ref : Zhonghua Er Ke Za Zhi , 41 :42 , 2003
PubMedID: 14761327

Title : Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation - Xiao_2002_J.Neurosci.Res_67_30
Author(s) : Xiao XQ , Zhang HY , Tang XC
Ref : Journal of Neuroscience Research , 67 :30 , 2002
PubMedID: 11754078

Title : Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine - Zhao_2002_Eur.J.Pharmacol_455_101
Author(s) : Zhao Q , Tang XC
Ref : European Journal of Pharmacology , 455 :101 , 2002
PubMedID: 12445575

Title : Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice - Zhang_2002_Neurosci.Lett_317_143
Author(s) : Zhang HY , Liang YQ , Tang XC , He XC , Bai DL
Ref : Neuroscience Letters , 317 :143 , 2002
PubMedID: 11755260

Title : Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells - Wang_2002_Brain.Res.Mol.Brain.Res_107_1
Author(s) : Wang R , Zhou J , Tang XC
Ref : Brain Research Mol Brain Res , 107 :1 , 2002
PubMedID: 12414117

Title : Isolation of acetylcholinesterase G4 and G1 molecular isoforms from rat cortex - Zhao_2002_Acta.Pharmacol.Sin_23_173
Author(s) : Zhao Q , Tang XC
Ref : Acta Pharmacol Sin , 23 :173 , 2002
PubMedID: 11866880

Title : X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement - Dvir_2002_Biochemistry_41_10810
Author(s) : Dvir H , Jiang H , Wong DM , Harel M , Chetrit M , He XC , Jin GY , Yu GL , Tang XC , Silman I , Bai DL , Sussman JL
Ref : Biochemistry , 41 :10810 , 2002
PubMedID: 12196020
Gene_locus related to this paper: torca-ACHE

Title : Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils - Zhou_2001_Neurosci.Lett_313_137
Author(s) : Zhou J , Zhang HY , Tang XC
Ref : Neuroscience Letters , 313 :137 , 2001
PubMedID: 11682146

Title : Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys - Ou_2001_Eur.J.Pharmacol_433_151
Author(s) : Ou LY , Tang XC , Cai JX
Ref : European Journal of Pharmacology , 433 :151 , 2001
PubMedID: 11755146

Title : Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation - Zhou_2001_Neurosci.Lett_306_53
Author(s) : Zhou J , Fu Y , Tang XC
Ref : Neuroscience Letters , 306 :53 , 2001
PubMedID: 11403956

Title : Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells - Wang_2001_Neuroreport_12_2629
Author(s) : Wang R , Xiao XQ , Tang XC
Ref : Neuroreport , 12 :2629 , 2001
PubMedID: 11522938

Title : Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells - Zhang_2000_Neurosci.Lett_292_41
Author(s) : Zhang HY , Tang XC
Ref : Neuroscience Letters , 292 :41 , 2000
PubMedID: 10996445

Title : Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats - Wang_2000_Eur.J.Pharmacol_398_65
Author(s) : Wang LM , Han YF , Tang XC
Ref : European Journal of Pharmacology , 398 :65 , 2000
PubMedID: 10856449

Title : Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury - Xiao_2000_J.Neurosci.Res_61_564
Author(s) : Xiao XQ , Wang R , Tang XC
Ref : Journal of Neuroscience Research , 61 :564 , 2000
PubMedID: 10956426

Title : Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells - Xiao_2000_Neurosci.Lett_286_155
Author(s) : Xiao XQ , Wang R , Han YF , Tang XC
Ref : Neuroscience Letters , 286 :155 , 2000
PubMedID: 10832008

Title : Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease - Bai_2000_Curr.Med.Chem_7_355
Author(s) : Bai DL , Tang XC , He XC
Ref : Curr Med Chem , 7 :355 , 2000
PubMedID: 10637369

Title : Inhibitory effects of huperzine B on cholinesterase activity in mice - Liu_1999_Zhongguo.Yao.Li.Xue.Bao_20_141
Author(s) : Liu J , Zhang HY , Wang LM , Tang XC
Ref : Zhongguo Yao Li Xue Bao , 20 :141 , 1999
PubMedID: 10437161

Title : Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment - Ye_1999_J.Pharmacol.Exp.Ther_288_814
Author(s) : Ye JW , Cai JX , Wang LM , Tang XC
Ref : Journal of Pharmacology & Experimental Therapeutics , 288 :814 , 1999
PubMedID: 9918593

Title : Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury - Xiao_1999_Neurosci.Lett_275_73
Author(s) : Xiao XQ , Yang JW , Tang XC
Ref : Neuroscience Letters , 275 :73 , 1999
PubMedID: 10568502

Title : Effects of huperzine A on nucleus basalis magnocellularis lesion- induced spatial working memory deficit - Xiong_1998_Zhongguo.Yao.Li.Xue.Bao_19_128
Author(s) : Xiong ZQ , Cheng DH , Tang XC
Ref : Acta Pharmacol Sin , 19 :128 , 1998
PubMedID: 10374634

Title : Anticholinesterase effects of huperzine A, E2020, and tacrine in rats - Wang_1998_Zhongguo.Yao.Li.Xue.Bao_19_27
Author(s) : Wang H , Tang XC
Ref : Acta Pharmacol Sin , 19 :27 , 1998
PubMedID: 10375753

Title : Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance - Liu_1998_Zhongguo.Yao.Li.Xue.Bao_19_413
Author(s) : Liu J , Zhang HY , Tang XC , Wang B , He XC , Bai DL
Ref : Acta Pharmacol Sin , 19 :413 , 1998
PubMedID: 10375798

Title : Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities - Cheng_1998_Pharmacol.Biochem.Behav_60_377
Author(s) : Cheng DH , Tang XC
Ref : Pharmacol Biochem Behav , 60 :377 , 1998
PubMedID: 9632220

Title : Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine - Wang_1998_Eur.J.Pharmacol_349_137
Author(s) : Wang T , Tang XC
Ref : European Journal of Pharmacology , 349 :137 , 1998
PubMedID: 9671090

Title : Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro - Lin_1997_Zhongguo.Yao.Li.Xue.Bao_18_6
Author(s) : Lin JH , Hu GY , Tang XC
Ref : Zhongguo Yao Li Xue Bao , 18 :6 , 1997
PubMedID: 10072886

Title : Huperzine A, a novel promising acetylcholinesterase inhibitor - Cheng_1996_Neuroreport_8_97
Author(s) : Cheng DH , Ren H , Tang XC
Ref : Neuroreport , 8 :97 , 1996
PubMedID: 9051760

Title : Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro - Lin_1996_Zhongguo.Yao.Li.Xue.Bao_17_299
Author(s) : Lin JH , Hu GY , Tang XC
Ref : Zhongguo Yao Li Xue Bao , 17 :299 , 1996
PubMedID: 9812706

Title : Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats - Xiong_1995_Pharmacol.Biochem.Behav_51_415
Author(s) : Xiong ZQ , Tang XC
Ref : Pharmacology, Biochemistry & Behavior , 51 :415 , 1995
PubMedID: 7667362

Title : Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment - Xiong_1995_Zhongguo.Yao.Li.Xue.Bao_16_21
Author(s) : Xiong ZQ , Tang XC , Lin JL , Zhu DY
Ref : Acta Pharmacol Sin , 16 :21 , 1995
PubMedID: 7771190

Title : Effect of cholinesterase inhibition in vitro by huperzine analogs - Tang_1994_Zhongguo.Yao.Li.Xue.Bao_15_107
Author(s) : Tang XC , Xu H , Feng J , Zhou TX , Liu JS
Ref : Acta Pharmacol Sin , 15 :107 , 1994
PubMedID: 8010100

Title : Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo - Tang_1994_J.Ethnopharmacol_44_147
Author(s) : Tang XC , Kindel GH , Kozikowski AP , Hanin I
Ref : J Ethnopharmacol , 44 :147 , 1994
PubMedID: 7898122

Title : Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo - Hanin_1993_Ann.N.Y.Acad.Sci_695_304
Author(s) : Hanin I , Tang XC , Kindel GL , Kozikowski AP
Ref : Annals of the New York Academy of Sciences , 695 :304 , 1993
PubMedID: 8239300

Title : Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters - Laganiere_1991_Neuropharmacol_30_763
Author(s) : Laganiere S , Corey J , Tang XC , Wulfert E , Hanin I
Ref : Neuropharmacology , 30 :763 , 1991
PubMedID: 1922687

Title : Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat - Tang_1989_J.Neurosci.Res_24_276
Author(s) : Tang XC , De Sarno P , Sugaya K , Giacobini E
Ref : Journal of Neuroscience Research , 24 :276 , 1989
PubMedID: 2585551

Title : The effect of heptyl-physostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat - De Sarno_1989_Neurochem.Res_14_971
Author(s) : De Sarno P , Pomponi M , Giacobini E , Tang XC , Williams E
Ref : Neurochemical Research , 14 :971 , 1989
PubMedID: 2608162

Title : [Cholinesterase inhibition by huperzine B] -
Author(s) : Xu H , Tang XC
Ref : Acta Pharmacol Sin , 8 :18 , 1987
PubMedID: 2955654