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| Title : Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists - Wang_2002_J.Med.Chem_45_5415 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Greenlee WJ , Clader J , Boyle CD , Kaminski JJ , Billard W , Binch H, 3rd , Crosby G , Ruperto V , Duffy RA , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Lachowicz JE |
| Ref : Journal of Medicinal Chemistry , 45 :5415 , 2002 |
| Abstract : Wang_2002_J.Med.Chem_45_5415 |
| ESTHER : Wang_2002_J.Med.Chem_45_5415 |
| PubMedSearch : Wang_2002_J.Med.Chem_45_5415 |
| PubMedID: 12459007 |
| Title : SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals - Carey_2001_Eur.J.Pharmacol_431_189 |
| Author(s) : Carey GJ , Billard W , Binch H , Cohen-Williams M , Crosby G , Grzelak M , Guzik H , Kozlowski JA , Lowe DB , Pond AJ , Tedesco RP , Watkins RW , Coffin VL |
| Ref : European Journal of Pharmacology , 431 :189 , 2001 |
| Abstract : Carey_2001_Eur.J.Pharmacol_431_189 |
| ESTHER : Carey_2001_Eur.J.Pharmacol_431_189 |
| PubMedSearch : Carey_2001_Eur.J.Pharmacol_431_189 |
| PubMedID: 11728425 |
| Title : Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788 - Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| Author(s) : Lachowicz JE , Duffy RA , Ruperto V , Kozlowski J , Zhou G , Clader J , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Strader CD , Coffin V |
| Ref : Life Sciences , 68 :2585 , 2001 |
| Abstract : Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| ESTHER : Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| PubMedSearch : Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| PubMedID: 11392630 |
| Title : Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution - Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| Author(s) : Boyle CD , Chackalamannil S , Clader JW , Greenlee WJ , Josien HB , Kaminski JJ , Kozlowski JA , McCombie SW , Nazareno DV , Tagat JR , Wang Y , Zhou G , Billard W , Binch H , Crosby G , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :2311 , 2001 |
| Abstract : Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| ESTHER : Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| PubMedSearch : Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| PubMedID: 11527721 |
| Title : Benzylidene ketal derivatives as M2 muscarinic receptor antagonists - Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| Author(s) : Boyle CD , Chackalamannil S , Chen LY , Dugar S , Pushpavanam P , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Coffin VL , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2727 , 2000 |
| Abstract : Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| ESTHER : Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| PubMedSearch : Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| PubMedID: 11133078 |
| Title : Cholinergic improvement of a naturally-occurring memory deficit in the young rat - Smith_1996_Brain.Res_707_13 |
| Author(s) : Smith RD , Kistler MK , Cohen-Williams M , Coffin VL |
| Ref : Brain Research , 707 :13 , 1996 |
| Abstract : Smith_1996_Brain.Res_707_13 |
| ESTHER : Smith_1996_Brain.Res_707_13 |
| PubMedSearch : Smith_1996_Brain.Res_707_13 |
| PubMedID: 8866709 |