Duf_676
Comment
This family is made up of a group of uncharacterised eukaryotic proteins that are distantly related to the abhydrolase. It contains IPR016445 Rog1 is a yeast monoacylglycerol (MAG) lipase Lipase and the paralogue YDL109c phospholipase Lpl1. PIRSF005412 UCP005412_abhydr. Selvaraju et al. identified a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae which belongs to this family. In animals the protein is very long. Only c-term is Duf_676 In human the protein is called family with sequence similarity 135 member A F135A
Database
Interpro : IPR044294 Lipase-like , IPR022122 Protein FAM135 , IPR007751 Domain of unknown function DUF676, lipase-like (DUF676_lipase-like) , IPR016445 Lipase Rog1 Rog1_fam
PIRSF : PIRSF005412 alpha\/beta hydrolase, YDL109c type
Pdoc : No Pdoc
Pfam : PF05057 DUF676
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9bact-AMWEst | Uncultured bacterium AMWEst esterase | uncultured bacterium |
| ailme-d2hti6 | Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein | Ailuropoda melanoleuca |
| ailme-d2hyv2 | Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein | Ailuropoda melanoleuca |
| anoga-q7q725 | Anopheles gambiae str. PEST ensangp00000021198 | Anopheles gambiae |
| arath-At1g09980 | Arabidopsis thaliana (Mouse-ear cress), Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress), hypothetical protein | Arabidopsis thaliana |
| arath-AT1G29120 | Arabidopsis thaliana (Mouse-ear cress), Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) hypothetical protein AT1G29120 | Arabidopsis thaliana |
| arath-AT4G25770 | Arabidopsis thaliana (Mouse-ear cress), Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) AT4G25770\/F14M19.50 hypothetical protein | Arabidopsis thaliana |
| arath-AT5G51180 | Arabidopsis thaliana (Mouse-ear cress) hypothetical protein | Arabidopsis thaliana |
| arath-At1g10040 | Arabidopsis thaliana (Mouse-ear cress) Alpha\/beta-hydrolases superfamily protein T27I1.6 At1g10040 | Arabidopsis thaliana |
| arath-ZW18 | Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) ZW18 protein (F19C14.4 protein) At1g58350 | Arabidopsis thaliana |
| ashgo-q75b57 | Ashbya gossypii (Yeast) (Eremothecium gossypii) adl285cp | Ashbya gossypii |
| ashgo-q753d0 | Ashbya gossypii (Yeast) (Eremothecium gossypii) afr386cp | Ashbya gossypii |
| ashgo-q756e3 | Ashbya gossypii (Yeast) (Eremothecium gossypii) aer322cp | Ashbya gossypii |
| ashgo-q759s1 | Ashbya gossypii (Yeast) (Eremothecium gossypii) adr202cp | Ashbya gossypii |
| aspfu-q4wex4 | Aspergillus fumigatus (Neosartorya fumigata), Neosartorya fischeri (Aspergillus fischerianus), duf676 domain protein | Aspergillus fumigatus Af293 |
| aspfu-q4wya2 | Aspergillus fumigatus Af293 duf676 domain protein | Aspergillus fumigatus Af293 |
| aspor-q2u728 | Aspergillus oryzae predicted alpha\/beta hydrolase | Aspergillus oryzae |
| aspor-q2urq0 | Aspergillus oryzae predicted alpha\/beta hydrolase | Aspergillus oryzae |
| bovin-e1bpw3 | Bos taurus (Bovine) Uncharacterized protein | Bos taurus |
| bovin-f1mcd9 | Bos taurus (Bovine) Uncharacterized protein | Bos taurus |
| caeel-C09D4.4 | Caenorhabditis elegans hypothetical 103.1 kda protein c09d4.4b c09d4.4c | Caenorhabditis elegans |
| canal-q5ak29 | Candida albicans SC5314 hypothetical protein | Candida albicans SC5314 |
| canal-q5ams2 | Candida albicans SC5314 hypothetical protein | Candida albicans SC5314 |
| canal-q59kl3 | Candida albicans potential lipid particle serine esterase | Candida albicans SC5314 |
| canal-q59ln6 | Candida albicans SC5314 hypothetical protein | Candida albicans SC5314 |
| canfa-f1ppp9 | Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein | Canis lupus familiaris |
| canfa-f1ptf1 | Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein | Canis lupus familiaris |
| canga-q6fj11 | Candida glabrata (Yeast) (Torulopsis glabrata) similar to tr|q04093 saccharomyces cerevisiae ydr444w | Candida glabrata |
| canga-q6fkm9 | Candida glabrata (Yeast) (Torulopsis glabrata) similar to tr|q08448 saccharomyces cerevisiae yor059c | Candida glabrata |
| canga-q6fr97 | Candida glabrata (Yeast) (Torulopsis glabrata) candida glabrata strain cbs138 chromosome h complete sequence | Candida glabrata |
| canga-q6fv41 | Candida glabrata (Yeast) (Torulopsis glabrata) candida glabrata strain cbs138 chromosome e complete sequence | Candida glabrata |
| chagb-q2h0t6 | Chaetomium globosum CBS 148.51 hypothetical protein | Chaetomium globosum CBS 148.51 |
| chagb-q2hgc9 | Chaetomium globosum CBS 148.51 hypothetical protein | Chaetomium globosum CBS 148.51 |
| chick-f1p508 | Gallus gallus (Chicken) Uncharacterized protein | Gallus gallus |
| cryne-q5kky1 | Cryptococcus neoformans (Filobasidiella neoformans) triacylglycerol lipase, putative | Cryptococcus neoformans |
| cryne-Q5KCH9 | Cryptococcus neoformans var. neoformans B-3501A hypothetical protein | Cryptococcus neoformans |
| cryne-q55ta1 | Cryptococcus neoformans var. neoformans B-3501A hypothetical protein | Cryptococcus neoformans |
| cryne-q55va3 | Cryptococcus neoformans, Cryptococcus gattii, hypothetical protein | Cryptococcus neoformans var. neoformans B-3501A |
| crypv-q5cph4 | Cryptosporidium parvum hypothetical protein | Cryptosporidium parvum |
| crypv-q5cr67 | Cryptosporidium parvum similar to a family of Arabidopsis proteins,transmembrane domain near n-terminus | Cryptosporidium parvum |
| debha-q6bh69 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to ca4761|ipf9650 candida albicans ipf9650 | Debaryomyces hansenii |
| debha-q6bhj7 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to ca5137|ipf1032 candida albicans ipf1032 | Debaryomyces hansenii |
| debha-q6bky4 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to ca3150|ipf4035 candida albicans ipf4035 | Debaryomyces hansenii |
| debha-q6bty5 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) similar to ca1159|ipf13423 candida albicans | Debaryomyces hansenii |
| dicdi-q54xl3 | Dictyostelium discoideum (Slime mold) hypothetical protein | Dictyostelium discoideum |
| dicdi-Q86HC9 | Dictyostelium discoideum (Slime mold) esterase\/lipase\/thioesterase domain-containing protein | Dictyostelium discoideum |
| drome-CG32333 | Drosophila melanogaster (Fruit fly) cg32333 protein | Drosophila melanogaster |
| eco57-b3a913 | Escherichia coli (O157:H7\/EC4401\/EC4486\/EC4076\/EC4196\/EC508\/TW14359\/EC4115\; MS 182-1\; B\/REL606) Putative uncharacterized protein | Escherichia coli |
| emeni-c8vrl3 | Emericella nidulans (strain FGSC A4 \/ ATCC 38163 \/ CBS 112.46 \/ NRRL 194 \/ M139) (Aspergillus nidulans) Lipase\/serine esterase, putative | Aspergillus nidulans FGSC A4 |
| emeni-q5b8p6 | Emericella nidulans (strain FGSC A4 \/ ATCC 38163 \/ CBS 112.46 \/ NRRL 194 \/ M139) (Aspergillus nidulans) hypothetical protein | Aspergillus nidulans FGSC A4 |
| enthi-q50rh1 | Entamoeba histolytica HM-1:IMSS hypothetical protein | Entamoeba histolytica HM-1:IMSS |
| enthi-q51ch3 | Entamoeba histolytica HM-1:IMSS hypothetical protein | Entamoeba histolytica HM-1:IMSS |
| giaia-e1f0e1 | Giardia lamblia, glp_574_145164_142861 | Giardia lamblia ATCC 50803 |
| giala-q7r424 | Giardia lamblia ATCC 50803 glp_68_6153_4942 | Giardia lamblia ATCC 50803 |
| gibze-q4hxk0 | Gibberella zeae (Fusarium graminearum) hypothetical protein | Gibberella zeae |
| gibze-q4i1b9 | Gibberella zeae (Fusarium graminearum) DUF676 domain-containing protein | Gibberella zeae |
| gibze-q4i7k1 | Gibberella zeae (Fusarium graminearum) DUF676 domain-containing protein | Gibberella zeae |
| gibze-q4ici9 | Gibberella zeae (Fusarium graminearum) hypothetical protein | Gibberella zeae |
| gibze-q4igi1 | Gibberella zeae (Fusarium graminearum) hypothetical protein | Gibberella zeae |
| human-FAM135A | Homo sapiens (Human) F135A DKFZp781H2319 FLJ20176 fis KIAA1411 previously human-F135A | Homo sapiens |
| human-FAM135B | Homo sapiens (Human) F135B loc51059 c8orfk32 protein | Homo sapiens |
| klula-q6cjq9 | Kluyveromyces lactis (Yeast) similar to ca|ca1159|ipf13423 candida albicans unknown function | Kluyveromyces lactis |
| klula-q6cjs1 | Kluyveromyces lactis (Yeast) similar to sgd|s0005585 saccharomyces cerevisiae yor059c | Kluyveromyces lactis |
| klula-q6cn71 | Kluyveromyces lactis (Yeast) similar to sp|p53118 saccharomyces cerevisiae ygl144c | Kluyveromyces lactis |
| klula-q6cwu7 | Kluyveromyces lactis (Yeast) similar to sgd|s0002852 saccharomyces cerevisiae ydr444w | Kluyveromyces lactis |
| legpa-q5x611 | Legionella pneumophila (strain Paris) hypothetical protein | Legionella pneumophila |
| leima-q4q819 | Leishmania major hypothetical protein | Leishmania major |
| leima-q4qb85 | Leishmania major hypothetical protein | Leishmania major |
| macfa-q4r8v0 | Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) loc51059 (loc51059) | Macaca fascicularis |
| medtr-q1s3y4 | Medicago truncatula (Barrel medic) hypothetical protein | Medicago truncatula |
| medtr-q1s746 | Medicago truncatula (Barrel medic) (esterase\/lipase\/thioesterase) | Medicago truncatula |
| medtr-q1spi8 | Medicago truncatula (Barrel medic) Alpha\/beta-hydrolase superfamily protein | Medicago truncatula |
| medtr-q1su07 | Medicago truncatula (Barrel medic) Serine esterase family protein, putative | Medicago truncatula |
| medtr-q1szf3 | Medicago truncatula (Barrel medic) Serine esterase family protein | Medicago truncatula |
| mouse-F135A | Mus musculus (Mouse) hypothetical Esterase\/lipase\/thioesterase family active site containing protein | Mus musculus |
| mouse-Q9DAI6 | Mus musculus (Mouse) family active site containing protein, similarity 135, member B | Mus musculus |
| neucr-18A7.150 | Neurospora crassa conserved hypothetical protein | Neurospora crassa |
| neucr-q7s828 | Neurospora crassa hypothetical protein | Neurospora crassa |
| orysa-Q949C9 | Oryza sativa subsp. japonica subsp. indica (Rice) hypothetical protein | Oryza sativa |
| orysa-q2qx94 | Oryza sativa subsp. japonica subsp. indica (Rice) serine esterase, putative | Oryza sativa |
| orysa-q6k4q2 | Oryza sativa subsp. indica subsp. japonica (Rice) oj1316_e06.21 | Oryza sativa |
| orysa-q6zac6 | Oryza sativa (japonica cultivar-group) p0409a07.8) | Oryza sativa |
| orysa-q6zdm1 | Oryza sativa (japonica cultivar-group) hypothetical protein p0025f03.21 | Oryza sativa |
| orysa-q75gj0 | Oryza sativa (japonica cultivar-group) expressed protein (putative serine esterase) | Oryza sativa |
| pig-f1rtt1 | Sus scrofa (Pig) Uncharacterized protein | Sus scrofa |
| plach-q4y6j0 | Plasmodium chabaudi hypothetical protein (fragment) | Plasmodium chabaudi |
| plaf7-q8iik5 | Plasmodium falciparum (isolate 3D7) PF3D7_1116100 Serine esterase, putative PF11_0168a | Plasmodium falciparum |
| playo-q7rmm1 | Plasmodium yoelii yoelii hypothetical protein | Plasmodium yoelii yoelii |
| ponab-F135A | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Protein FAM135A | Pongo abelii |
| rat-d3zxw8 | Rattus norvegicus (Rat) Protein Fam135a Similar to KIAA1411 protein | Rattus norvegicus |
| rat-f1lz91 | Rattus norvegicus (Rat) Protein RGD1308133 | Rattus norvegicus |
| rhop2-q2itw9 | Rhodopseudomonas palustris (strain HaA2) hypothetical protein | Rhodopseudomonas palustris |
| schpo-ye7a | Schizosaccharomyces pombe (Fission yeast) hypothetical protein c4a8.10 in chromosome i | Schizosaccharomyces pombe |
| tetng-q4s050 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 21 scaf14785, whole genome shotgun sequence | Tetraodon nigroviridis |
| tetts-q23d68 | Tetrahymena thermophila SB210 hypothetical protein | Tetrahymena thermophila SB210 |
| tetts-q23pl2 | Tetrahymena thermophila SB210 hypothetical protein | Tetrahymena thermophila SB210 |
| tetts-q23q06 | Tetrahymena thermophila SB210 putative serine esterase | Tetrahymena thermophila SB210 |
| tetts-q23qe7 | Tetrahymena thermophila SB210 serine esterase, putative | Tetrahymena thermophila SB210 |
| tetts-q247n8 | Tetrahymena thermophila SB210 putative serine esterase | Tetrahymena thermophila SB210 |
| thean-q4uc93 | Theileria annulata hypothetical protein | Theileria annulata |
| thepa-q4n006 | Theileria parva hypothetical protein | Theileria parva |
| tryb2-q57xb7 | Trypanosoma brucei hypothetical protein | Trypanosoma brucei |
| tryb2-q383a9 | Trypanosoma brucei hypothetical protein | Trypanosoma brucei |
| trycr-q4cxr6 | Trypanosoma cruzi hypothetical protein | Trypanosoma cruzi |
| trycr-q4cyf6 | Trypanosoma cruzi hypothetical protein | Trypanosoma cruzi |
| trycr-q4d1s2 | Trypanosoma cruzi hypothetical protein | Trypanosoma cruzi |
| trycr-q4dbm2 | Trypanosoma cruzi hypothetical protein | Trypanosoma cruzi |
| ustma-q4p8v8 | Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein | Ustilago maydis 521 |
| xenla-q641i1 | Xenopus laevis (African clawed frog) F135B mgc81353 protein | Xenopus laevis |
| yarli-q6c3l1 | Yarrowia lipolytica (Candida lipolytica) similar to klla0f16709g kluyveromyces lactis | Yarrowia lipolytica |
| yarli-q6cep3 | Yarrowia lipolytica (Candida lipolytica) lipolytica | Yarrowia lipolytica |
| yeast-ROG1 | Saccharomyces cerevisiae (Baker's yeast) Putative lipase ROG1 ygo4 78.1 kda protein in tip20-mrf1 intergenic region ygl144c | Saccharomyces cerevisiae |
| yeast-YDL109C | Saccharomyces cerevisiae (Baker's yeast) chromosome IV reading frame orf ydl109c | Saccharomyces cerevisiae |
| yeast-YDR444W | Saccharomyces cerevisiae (Baker's yeast) d9461.29p | Saccharomyces cerevisiae |
| yeast-yo059 | Saccharomyces cerevisiae (Baker's yeast) Putative lipase YOR059C LPL1 chromosome xv orf yor059c YOR29-10 | Saccharomyces cerevisiae |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| arath-F21M12.37 | Arabidopsis thaliana (Mouse-ear cress) f21m12.37 protein | Arabidopsis thaliana |
| bracm-q4ac09 | Brassica campestris (Field mustard) 117m18_11 | Brassica campestris |
| orysa-q53pv0 | Oryza sativa subsp. japonica (Rice) putative serine esterase (duf676) | Oryza sativa |
| plaba-q4ywz6 | Plasmodium berghei hypothetical protein (fragment) | Plasmodium berghei |
| plaba-q4z5j8 | Plasmodium berghei hypothetical protein (fragment) | Plasmodium berghei |
| schja-q5dds9 | Schistosoma japonicum (Blood fluke, platyhelminth) sjchgc04274 protein | Schistosoma japonicum |
| tetng-q4rq85 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 17 scaf15006, whole genome shotgun sequence | Tetraodon nigroviridis |
| tetng-q4tcg8 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) | Tetraodon nigroviridis |
| 9basi-a0a3g2s9r6 | Malassezia restricta CBS 7877. Lipase 2 | Malassezia restricta CBS 7877 |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| TopFluor-LPE | 1-palmitoyl-2-(dipyrrometheneboron difluoride)undecanoyl-sn-glycero-3-phosphoethanolamine |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| Sal-A-alkyne | plafa-PF10.0020 plafa-PF07.0040 plafa-a0a143zya4 plafa-PF10.0379 plafa-PF13.0153 plaf7-q8iik5 plaf7-q8ii19 plafa-MAL8P1.138 | |
| Salinipostin-A | (3R,8aS)-5-butyl-3-oxo-3-pentadecoxy-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one | plafa-PF10.0020 plafa-PF07.0040 plafa-a0a143zya4 plafa-PF10.0379 plafa-PF13.0153 plaf7-q8iik5 plaf7-q8ii19 plafa-MAL8P1.138 |
References (2)
| Title : AMWEst, a new thermostable and detergent-tolerant esterase retrieved from the Albian aquifer - Adjeroud_2024_Appl.Microbiol.Biotechnol_108_1 |
| Author(s) : Adjeroud M , Kecha M , Escuder-Rodriguez JJ , Becerra M , Gonzalez-Siso MI |
| Ref : Applied Microbiology & Biotechnology , 108 :1 , 2024 |
| Abstract : |
| PubMedSearch : Adjeroud_2024_Appl.Microbiol.Biotechnol_108_1 |
| PubMedID: 38204131 |
| Gene_locus related to this paper: 9bact-AMWEst |
| Title : Identification of a phospholipase B encoded by the LPL1 gene in Saccharomyces cerevisiae - Selvaraju_2014_Biochim.Biophys.Acta_1841_1383 |
| Author(s) : Selvaraju K , Rajakumar S , Nachiappan V |
| Ref : Biochimica & Biophysica Acta , 1841 :1383 , 2014 |
| Abstract : |
| PubMedSearch : Selvaraju_2014_Biochim.Biophys.Acta_1841_1383 |
| PubMedID: 25014274 |
| Gene_locus related to this paper: yeast-yo059 |