Family: PMH_Peptidase_S9

Block: X

Parent Family: Peptidase_S9


Puromycine hydrolase (and also pQQM from Pseudomonas, C. Elegans dp4). Some Streptomyces strains produce Puromycin (PM classified into a family of nucleoside antibiotics) and express a PM-inactivating enzyme as a self-resistance determinant which is homologous to Peptidase S9


Interpro : IPR011042 6-blade_b-propeller_TolB-like , IPR001375 Peptidase_S9


Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (4)

Genes Proteins in PMH_Peptidase_S9 family (92)

Fragments of genes in PMH_Peptidase_S9 family (7)

Structures in PMH_Peptidase_S9 family (4)

Substrates in PMH_Peptidase_S9 family (3)

No Inhibitor

References (3)

Title : Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity - Zhao_2021_Proteins__
Author(s) : Zhao Y , Feng Q , Zhou X , Zhang Y , Lukman M , Jiang J , Ruiz-Carrillo D
Ref : Proteins , : , 2021
PubMedID: 33426726
Gene_locus related to this paper: myctu-CNE19725

Title : Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold -
Author(s) : Matoba Y , Nakayama A , Oda K , Noda M , Kumagai T , Nishimura M , Sugiyama M
Ref : Proteins , 79 :2999 , 2011
PubMedID: 21905123
Gene_locus related to this paper: strmo-q2hxd9

Title : Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis - Nishimura_2006_J.Biosci.Bioeng_101_63
Author(s) : Nishimura M , Ikeda K , Sugiyama M
Ref : J Biosci Bioeng , 101 :63 , 2006
PubMedID: 16503293
Gene_locus related to this paper: strmo-q2hxd9