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PMH_Peptidase_S9

Relationship

Family: PMH_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

Puromycine hydrolase (and also pQQM from Pseudomonas, C. Elegans dp4). Some Streptomyces strains produce Puromycin (PM classified into a family of nucleoside antibiotics) and express a PM-inactivating enzyme as a self-resistance determinant which is homologous to Peptidase S9

Database

Interpro : IPR011042 6-blade_b-propeller_TolB-like , IPR001375 Peptidase_S9

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
3AZO Crystal structure of puromycin hydrolase strmo-q2hxd9
3AZP Crystal structure of puromycin hydrolase S511A mutant strmo-q2hxd9
3AZQ Crystal structure of puromycin hydrolase S511A mutant complexed with PGG strmo-q2hxd9
7C72 Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase myctu-CNE19725

Gene_locus Name Species
9arch-d1ja37 uncultured archaeon Putative uncharacterized protein uncultured archaeon
9gamm-b8khu9 gamma proteobacterium NOR5-3 Peptidase S9, prolyl oligopeptidase active site region gamma proteobacterium NOR5-3
9gamm-q1ys81 marine gamma proteobacterium HTCC2207 hypothetical protein marine gamma proteobacterium HTCC2207
9gamm-q2bnq0 Oceanospirillum sp. MED92 peptidase s9, prolyl oligopeptidase active site region Oceanospirillum sp. MED92
9gamm-q2x1b8 Shewanella sp. W3-18-1 and Shewanella baltica OS155 prolyl oligopeptidase family protein Shewanella baltica OS155
9gamm-q3qfv5 Shewanella amazonensis SB2B peptidase s9, prolyl oligopeptidase active site region precursor Shewanella amazonensis SB2B
acice-q2dzi2 Acidothermus cellulolyticus 11B dipeptidyl aminopeptidases\/acylaminoacyl-peptidases-like Acidothermus cellulolyticus 11B
arall-d7mi04 Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Predicted protein Arabidopsis lyrata subsp. lyrata
arath-Q9FG66 Arabidopsis thaliana (Mouse-ear cress) acyl-peptide hydrolase-like At5g36210 T30G6.2 Arabidopsis thaliana
artoc-c5fwv8 Arthroderma otae (strain ATCC MYA-4605 \/ CBS 113480) (Microsporum canis) Aminopeptidase C Arthroderma otae
ascsu-f1l1k4 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) Dipeptidyl peptidase family member 6 Ascaris suum
aspni-APSC Aspergillus niger aminopeptidase c, Putative uncharacterized protein An04g02850 Aspergillus niger
aspor-q2u3l6 Aspergillus oryzae, Aspergillus flavus dipeptidyl aminopeptidases\/acylaminoacyl- peptidases Aspergillus oryzae
auran-f0ycp7 Aureococcus anophagefferens (Harmful bloom alga) Putative uncharacterized protein Aureococcus anophagefferens
azovi-q4j3i8 Azotobacter vinelandii AvOP probable peptidase Azotobacter vinelandii AvOP
brafl-c3y087 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
bruma-a8ndk6 Brugia malayi (Filarial nematode worm) Prolyl oligopeptidase family protein Brugia malayi
caebr-a8x7v6 Caenorhabditis briggsae CBR-DPF-4 protein Caenorhabditis briggsae
caeel-F01F1.5 Caenorhabditis elegans similar to acylaminoacyl-peptidase Caenorhabditis elegans
caere-e3lyt9 Caenorhabditis remanei (Caenorhabditis vulgaris) CRE-DPF-4 protein Caenorhabditis remanei
capo3-e9bxs2 Capsaspora owczarzaki (strain ATCC 30864) Predicted protein Capsaspora owczarzaki
chlau-q3e1h3 Chloroflexus aurantiacus J-10-fl peptidase s9, prolyl oligopeptidase active site region Chloroflexus aurantiacus J-10-fl
chlre-a8icg4 Chlamydomonas reinhardtii (Chlamydomonas smithii) Predicted protein Chlamydomonas reinhardtii
chlva-e1ztt0 Chlorella variabilis (Green alga) Putative uncharacterized protein Chlorella variabilis
colgm-e3qtt9 Colletotrichum graminicola (strain M1.001 \/ M2 \/ FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) Prolyl oligopeptidase Colletotrichum graminicola
copc7-d6rlx1 Coprinopsis cinerea (strain Okayama-7 \/ 130 \/ ATCC MYA-4618 \/ FGS 9003) (Inky cap fungus) (Hormographiella aspergillata) Peptidase Coprinopsis cinerea
coxbu-CBU1529 Coxiella burnetii prolyl oligopeptidase family protein Coxiella burnetii
crowt-q4c513 Crocosphaera watsonii peptidase s9, prolyl oligopeptidase active site region precursor Crocosphaera watsonii
dicdi-q54in4 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
gibze-i1s4q6 Gibberella zeae (Fusarium graminearum) hypothetical protein Gibberella zeae
glovi-q7nkk7 Gloeobacter violaceus gll1470 protein Gloeobacter violaceus
grocl-f0xl11 Grosmannia clavigera (strain kw1407 \/ UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera) Peptidase s9 prolyl oligopeptidase active site domain containing protein Grosmannia clavigera
horvd-f2ebk6 Hordeum vulgare var. distichum (Two-rowed barley) Predicted protein Hordeum vulgare var. distichum
kinra-q412v1 Kineococcus radiotolerans SRS30216 peptidase s9, prolyl oligopeptidase active site region precursor Kineococcus radiotolerans SRS30216
loalo-e1flc5 Loa loa (Eye worm) (Filaria loa) Prolyl oligopeptidase Loa loa
maize-b6uhc0 Zea mays (Maize) Putative uncharacterized protein Zea mays
metaq-e9e6i5 Metarhizium acridum (strain CQMa 102) Dipeptidyl peptidase IV, putative Metarhizium acridum
metar-e9eyx6 Metarhizium robertsii (strain ARSEF 23 \/ ATCC MYA-3075) (Metarhizium anisopliae) Dipeptidyl peptidase IV, putative Metarhizium robertsii
myctu-CNE19725 Mycobacterium tuberculosis Puromycine hydrolase Mycobacterium tuberculosis
naegr-d2vmj5 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
natmm-d3t286 Natrialba magadii (strain ATCC 43099 \/ DSM 3394 \/ NCIMB 2190 \/ MS3)(Natronobacterium magadii) Peptidase S9 prolyl oligopeptidase active site domain protein Natrialba magadii
nech7-c7yir8 Nectria haematococca (strain 77-13-4 \/ ATCC MYA-4622 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Putative uncharacterized protein Nectria haematococca
nech7-c7zr59 Nectria haematococca (strain 77-13-4 \/ ATCC MYA-4622 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Putative uncharacterized protein Nectria haematococca
nemve-a7rwv1 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nitoc-q3jby6 Nitrosococcus oceani (strains ATCC 19707 \/ NCIMB 11848\; AFC27) peptidase s9, prolyl oligopeptidase active site region (EC 3.4.19.1) Nitrosococcus oceani
orysa-q69ti3 Oryza sativa (japonica cultivar-group and subsp. indica) putative aminopeptidase c Oryza sativa
orysa-q69y12 Oryza sativa (japonica cultivar-group and subsp. indica) putative aminopeptidase c Oryza sativa
phypa-a9syy4 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
picsi-a9nwz2 Picea sitchensis (Sitka spruce) (Pinus sitchensis) Putative uncharacterized protein Picea sitchensis
polpa-d3bca7 Polysphondylium pallidum (Cellular slime mold) Putative uncharacterized protein Polysphondylium pallidum
poptr-b9gny4 Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein Populus trichocarpa
pospm-b8php7 Postia placenta (strain ATCC 44394 \/ Madison 698-R) (Brown rot fungus) (Poria monticola) Predicted protein Postia placenta
proma-q7ved1 Prochlorococcus marinus dipeptidyl aminopeptidase family enzyme Prochlorococcus marinus
promm-q7v5f8 Prochlorococcus marinus (strain MIT 9313) dienelactone hydrolase Prochlorococcus marinus
promp-q7v3k6 Prochlorococcus marinus subsp. pastoris (strain CCMP 1378 \/ MED4) (and strain MIT 9312) esterase\/lipase\/thioesterase family active site Prochlorococcus marinus
promt-q46hv8 Prochlorococcus marinus (strain NATL2A) dienelactone hydrolase Prochlorococcus marinus
pse14-q48ct2 Pseudomonas syringae pv. phaseolicola (strain 1448A \/ Race 6) prolyl oligopeptidase family protein Pseudomonas syringae pv. phaseolicola
pseae-PA1990 Pseudomonas aeruginosa probable peptidase Pseudomonas aeruginosa
psef5-q4k4u7 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) prolyl oligopeptidase family protein Pseudomonas fluorescens
psefl-q32x72 Pseudomonas fluorescens dipeptidyl aminopeptidase\/acylaminoacyl-peptidase Pseudomonas fluorescens
psepf-q3k5q5 Pseudomonas fluorescens (strain PfO-1) peptidase s9, prolyl oligopeptidase active site region Pseudomonas fluorescens
psepu-PP0375 Pseudomonas putida (strain KT2440 and strain F1) prolyl oligopeptidase family protein Pseudomonas putida
psesy-PSPTO0508 Pseudomonas syringae (pv. tomato) conserved hypothetical protein Pseudomonas syringae
pseu2-q4zmc0 Pseudomonas syringae pv. syringae (strain B728a) peptidase s9, prolyl oligopeptidase active site region Pseudomonas syringae pv. syringae
rapsa-dpp5like Raphanus sativus dipeptidyl-peptidase 5-like Raphanus sativus
ricco-b9r7h7 Ricinus communis (Castor bean) Acylamino-acid-releasing enzyme, putative Ricinus communis
rubxd-Q1AYE9 Rubrobacter xylanophilus DSM 9941 similar to dipeptidyl aminopeptidases\/acylaminoacyl-peptidases Rubrobacter xylanophilus DSM 9941
sacd2-q21ld1 Saccharophagus degradans (strain 2-40 \/ ATCC 43961 \/ DSM 17024) hypothetical protein Saccharophagus degradans
schcm-d8q5m5 Schizophyllum commune (strain H4-8 \/ FGSC 9210) (Split gill fungus) Putative uncharacterized protein Schizophyllum commune
schcm-d8q7x7.1 Schizophyllum commune (strain H4-8 \/ FGSC 9210) (Split gill fungus) Putative uncharacterized protein Schizophyllum commune
selml-d8qva1 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
selml-d8taz4 Selaginella moellendorffii (Spikemoss) Putative uncharacterized protein Selaginella moellendorffii
shelp-a3qdj4 Shewanella loihica (strain ATCC BAA-1088 \/ PV-4), peptidase s9, prolyl oligopeptidase active site region precursor Shewanella sp. PV-4
sheon-SO1686 Shewanella oneidensis, Shewanella sp., Shewanella putrefaciens, prolyl oligopeptidase family protein Shewanella oneidensis
sorbi-c5z6j1 Sorghum bicolor (Sorghum) (Sorghum vulgare) Putative uncharacterized protein Sb10g007270 Sorghum bicolor
strav-SAV1898 Streptomyces avermitilis putative acyl-peptide hydrolase Streptomyces avermitilis
strco-SCO6488 Streptomyces coelicolor Streptomyces lividans TK24 putative acyl-peptide hydrolase Streptomyces coelicolor
strmo-q2hxd9 Streptomyces morookaensis (Streptoverticillium morookaense) puromycin hydrolase Streptomyces morookaensis
synja-q2jqh6 Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) peptidase, s9c (acylaminoacyl-peptidase) family (EC 3.4.-.-) Synechococcus sp.
synjb-q2jk37 Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) peptidase, s9c (acylaminoacyl-peptidase) family (EC 3.4.-.-) Synechococcus sp.
synp6-q5n0e0 Synechococcus sp. (strain PCC 6301) (Anacystis nidulans) (strain PCC 7942) (Anacystis nidulans R2) probable peptidase Synechococcus sp.
synpx-q7u9d5 Synechococcus sp. (strain WH8102) putative peptidase Synechococcus sp.
syns9-q3azu9 Synechococcus sp. (strain CC9902) putative peptidase Synechococcus sp.
synsc-q3ahc3 Synechococcus sp. (strain CC9605) putative peptidase Synechococcus sp.
synsp-SLR0825 Synechocystis sp. (strain PCC 6803) hypothetical 70.2 kda protein Synechocystis sp.
talsn-b8ltf8 Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Dipeptidyl peptidase IV, putative Talaromyces stipitatus
thaps-b8bxb3 Thalassiosira pseudonana (Marine diatom) (Cyclotella nana) Predicted protein Thalassiosira pseudonana
theeb-TLR1685 Thermosynechococcus elongatus (strain BP-1) tlr1685 protein Thermosynechococcus elongatus
thefy-q47rs3 Thermobifida fusca (strain YX) putative acyl-peptide hydrolase Thermobifida fusca
triei-q115z2 Trichodesmium erythraeum (strain IMS101) peptidase s9, prolyl oligopeptidase active site region Trichodesmium erythraeum IMS101
trisp-e5s8m6 Trichinella spiralis (Trichina worm) Peptidase, S9C family Trichinella spiralis
uncre-c4jf79 Uncinocarpus reesii (strain UAMH 1704) Predicted protein Uncinocarpus reesii

Gene_locus_frgt Name Species
gluox-q5fs43 Gluconobacter oxydans (Gluconobacter suboxydans) acyl-peptide hydrolase-like protein Gluconobacter oxydans
lacbs-b0duz0 Laccaria bicolor (strain S238N-H82 \/ ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) Predicted protein Laccaria bicolor
lacbs-b0e152 Laccaria bicolor (strain S238N-H82 \/ ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) Predicted protein Laccaria bicolor
monpe-e2l6s1 Moniliophthora perniciosa (strain FA553 \/ isolate CP02) (Witches'-broom disease fungus) (Marasmius perniciosus) Putative uncharacterized protein Moniliophthora perniciosa
spore-e6zx18 Sporisorium reilianum (strain SRZ2) (Maize head smut fungus) Putative uncharacterized protein Sporisorium reilianum
ustma-q4pea4 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
volca-d8u852 Volvox carteri (Green alga) Putative uncharacterized protein Volvox carteri

Substrate Chemical Nomenclature Proteins
Pro-Gly-Gly 2-[[2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetyl]amino]acetic acid
Prolyl-2-naphthylamide N-naphthalen-2-ylpyrrolidine-2-carboxamide pig-EST1    myctu-CNE19725
Puromycin (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide

References (3)

Title : Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity - Zhao_2021_Proteins__
Author(s) : Zhao Y , Feng Q , Zhou X , Zhang Y , Lukman M , Jiang J , Ruiz-Carrillo D
Ref : Proteins , : , 2021
Abstract :
PubMedSearch : Zhao_2021_Proteins__
PubMedID: 33426726
Gene_locus related to this paper: myctu-CNE19725

Title : Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold -
Author(s) : Matoba Y , Nakayama A , Oda K , Noda M , Kumagai T , Nishimura M , Sugiyama M
Ref : Proteins , 79 :2999 , 2011
PubMedID: 21905123
Gene_locus related to this paper: strmo-q2hxd9

Title : Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis - Nishimura_2006_J.Biosci.Bioeng_101_63
Author(s) : Nishimura M , Ikeda K , Sugiyama M
Ref : J Biosci Bioeng , 101 :63 , 2006
Abstract :
PubMedSearch : Nishimura_2006_J.Biosci.Bioeng_101_63
PubMedID: 16503293
Gene_locus related to this paper: strmo-q2hxd9