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Family Report for: AHL-acylase


Block X
Parent Family : Abhydrolase_6

Bacterial AHL-acylases (acyl homoserine lactonase) (AiiO, AidH) from genus Ochrobactrum and related bacteria are different from previously described AHL-acylases such as PvdQ, QuiP (P.aeriginosa) HacA HacB (P.syringea which belong to Ntn-hydrolase superfamily Czajkowski et al.) and different from AHL-lactonase of B. thuringensis and A. tumefasciens (which are metallo-beta lactamases). AHL-acylase inactivates N-acyl homoserine lactone (AHL) quorum sensing signal molecules (lactonases are also inactivating enzymes). AHL-acylases could be useful for the control of development of infections caused by pathogenic bacteria and their persistence in respective hosts. The three fungi sequences are genes without real introns (horizontal transfer?). There are other N-acyl homoserine lactonase (AiiA) not alpha/beta hydroalses but Metallo-B-lactamases

PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase
    Gao A, Mei GY, Liu S, Wang P, Tang Q, Liu YP, Wen H, An XM, Zhang LQ and Liang DC <1 more author(s)>
    Ref: Acta Crystallographica D Biol Crystallogr, 69:82, 2013 : PubMed


    Title: Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase
    Czajkowski R, Krzyzanowska D, Karczewska J, Atkinson S, Przysowa J, Lojkowska E, Williams P, Jafra S
    Ref: Environ Microbiol Rep, 3:59, 2011 : PubMed


    Title: Quenching of acyl-homoserine lactone-dependent quorum sensing by enzymatic disruption of signal molecules.
    Czajkowski R, Jafra S
    Ref: Acta Biochim Pol, 56:1, 2009 : PubMed


Other Papers

No structure scheme yet for this family

Structures in AHL-acylase family (6)

Genes Proteins in AHL-acylase family (24)

No fragments
Substrates of some enzymes in the AHL-acylase family (4)

Inhibitors of some enzymes in the AHL-acylase family (2)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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