1. Home
  2. Family
  3. AHL-acylase

AHL-acylase

Relationship

Family: AHL-acylase

Block: X

Parent Family: Abhydrolase_6

Comment

Bacterial AHL-acylases (acyl homoserine lactonase) (AiiO, AidH) from genus Ochrobactrum and related bacteria are different from previously described AHL-acylases such as PvdQ, QuiP (P.aeriginosa) HacA HacB (P.syringea which belong to Ntn-hydrolase superfamily Czajkowski et al.) and different from AHL-lactonase of B. thuringensis and A. tumefasciens (which are metallo-beta lactamases). AHL-acylase inactivates N-acyl homoserine lactone (AHL) quorum sensing signal molecules (lactonases are also inactivating enzymes). AHL-acylases could be useful for the control of development of infections caused by pathogenic bacteria and their persistence in respective hosts. The three fungi sequences are genes without real introns (horizontal transfer?). There are other N-acyl homoserine lactonase (AiiA) not alpha/beta hydroalses but Metallo-B-lactamases

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (4)

Title : High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase - Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82
Author(s) : Gao A , Mei GY , Liu S , Wang P , Tang Q , Liu YP , Wen H , An XM , Zhang LQ , Yan XX , Liang DC
Ref : Acta Crystallographica D Biol Crystallogr , 69 :82 , 2013
Abstract : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82
ESTHER : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82
PubMedSearch : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82
PubMedID: 23275166
Gene_locus related to this paper: 9rhiz-d2j2t6

Title : Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase - Czajkowski_2011_Environ.Microbiol.Rep_3_59
Author(s) : Czajkowski R , Krzyzanowska D , Karczewska J , Atkinson S , Przysowa J , Lojkowska E , Williams P , Jafra S
Ref : Environ Microbiol Rep , 3 :59 , 2011
Abstract : Czajkowski_2011_Environ.Microbiol.Rep_3_59
ESTHER : Czajkowski_2011_Environ.Microbiol.Rep_3_59
PubMedSearch : Czajkowski_2011_Environ.Microbiol.Rep_3_59
PubMedID: 23761232
Gene_locus related to this paper: 9rhiz-d8x182

Title : AidH, an alpha\/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonase - Mei_2010_Appl.Environ.Microbiol_76_4933
Author(s) : Mei GY , Yan XX , Turak A , Luo ZQ , Zhang LQ
Ref : Applied Environmental Microbiology , 76 :4933 , 2010
Abstract : Mei_2010_Appl.Environ.Microbiol_76_4933
ESTHER : Mei_2010_Appl.Environ.Microbiol_76_4933
PubMedSearch : Mei_2010_Appl.Environ.Microbiol_76_4933
PubMedID: 20525860
Gene_locus related to this paper: 9rhiz-d2j2t6

Title : Quenching of acyl-homoserine lactone-dependent quorum sensing by enzymatic disruption of signal molecules. - Czajkowski_2009_Acta.Biochim.Pol_56_1
Author(s) : Czajkowski R , Jafra S
Ref : Acta Biochim Pol , 56 :1 , 2009
Abstract : Czajkowski_2009_Acta.Biochim.Pol_56_1
ESTHER : Czajkowski_2009_Acta.Biochim.Pol_56_1
PubMedSearch : Czajkowski_2009_Acta.Biochim.Pol_56_1
PubMedID: 19287806

Structures (6)

Genes Proteins in AHL-acylase family (24)

No fragment of genes

Structures in AHL-acylase family (6)

Substrates in AHL-acylase family (4)

Inhibitors in AHL-acylase family (2)