arath-PAD4
Arabidopsis thaliana (Mouse-ear cress) PAD4 lipase 61.0 kda protein EDS9 At3g52430 AtPAD4 (phytoalexin-deficient 4)
Comment
The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 and SAG101 (arath-At5g14930) Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1\/EDS1\/SAG101 and ADR1\/EDS1\/PAD4) mediate TNL receptor defence signalling.
Relationship
Family : Plant_lipase_EDS1-like
Block : L
Position in NCBI Life Tree : Arabidopsis thaliana
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N EMolecular evidence
No mutation
7XDD - Cryo-EM structure of Arabidopsis thaliana lipase EDS1 (Enhanced disease susceptibility 1-like) and PAD4(phytoalexin-deficient 4)
7XEY - EDS1-PAD4 complexed with pRib-ADP
8ZW9 - Arabidopsis thaliana EDS1-PAD4-ADR1 heterotrimer by RPS4
8ZWA - Arabidopsis thaliana EDS1-PAD4-ADR1 heterotrimer by HopBY
No kinetic
No disease
Database
Sequence
Peptide
MDDCRFETSE LQASVMISTP LFTDSWSSCN TANCNGSIKI HDIAGITYVA IPAVSMIQLG NLVGLPVTGD VLFPGLSSDE PLPMVDAAIL KLFLQLKIKE GLELELLGKK LVVITGHSTG GALAAFTALW LLSQSSPPSF RVFCITFGSP LLGNQSLSTS ISRSRLAHNF CHVVSIHDLV PRSSNEQFWP FGTYLFCSDK GGVCLDNAGS VRLMFNILNT TATQNTEEHQ RYGHYVFTLS HMFLKSRSFL GGSIPDNSYQ AGVALAVEAL GFSNDDTSGV LVKECIETAT RIVRAPILRS AELANELASV LPARLEIQWY KDRCDASEEQ LGYYDFFKRY SLKRDFKVNM SRIRLAKFWD TVIKMVETNE LPFDFHLGKK WIYASQFYQL LAEPLDIANF YKNRDIKTGG HYLEGNRPKR YEVIDKWQKG VKVPEECVRS RYASTTQDTC FWAKLEQAKE WLDEARKESS DPQRRSLLRE KIVPFESYAN TLVTKKEVSL DVKAKNSSYS VWEANLKEFK CKMGYENEIE MVVDESDAME T
References (19)
| Title : Activation of a helper NLR by plant and bacterial TIR immune signaling - Yu_2024_Science__eadr3150 |
| Author(s) : Yu H , Xu W , Chen S , Wu X , Rao W , Liu X , Xu X , Chen J , Nishimura MT , Zhang Y , Wan L |
| Ref : Science , :eadr3150 , 2024 |
| Abstract : |
| PubMedSearch : Yu_2024_Science__eadr3150 |
| PubMedID: 39509471 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity - Huang_2022_Science_377_eabq3297 |
| Author(s) : Huang S , Jia A , Song W , Hessler G , Meng Y , Sun Y , Xu L , Laessle H , Jirschitzka J , Ma S , Xiao Y , Yu D , Hou J , Liu R , Sun H , Liu X , Han Z , Chang J , Parker JE , Chai J |
| Ref : Science , 377 :eabq3297 , 2022 |
| Abstract : |
| PubMedSearch : Huang_2022_Science_377_eabq3297 |
| PubMedID: 35857645 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__ |
| Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE |
| Ref : Plant J , : , 2022 |
| Abstract : |
| PubMedSearch : Dongus_2022_Plant.J__ |
| PubMedID: 35324052 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : PopP2 interacts with PAD4 in an acetyltransferase activity-dependent manner and affects plant immunity - Huh_2022_Plant.Signal.Behav__2017631 |
| Author(s) : Huh SU |
| Ref : Plant Signal Behav , :2017631 , 2022 |
| Abstract : |
| PubMedSearch : Huh_2022_Plant.Signal.Behav__2017631 |
| PubMedID: 34978271 |
| Gene_locus related to this paper: arath-PAD4 |
| Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335 |
| Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE |
| Ref : Nat Commun , 12 :3335 , 2021 |
| Abstract : |
| PubMedSearch : Sun_2021_Nat.Commun_12_3335 |
| PubMedID: 34099661 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430 |
| Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE |
| Ref : Plant Cell , 31 :2430 , 2019 |
| Abstract : |
| PubMedSearch : Lapin_2019_Plant.Cell_31_2430 |
| PubMedID: 31311833 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619 |
| Author(s) : Wagner S , Stuttmann J , Rietz S , Guerois R , Brunstein E , Bautor J , Niefind K , Parker JE |
| Ref : Cell Host Microbe , 14 :619 , 2013 |
| Abstract : |
| PubMedSearch : Wagner_2013_Cell.Host.Microbe_14_619 |
| PubMedID: 24331460 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis - Kim_2012_Plant.Cell_24_5177 |
| Author(s) : Kim TH , Kunz HH , Bhattacharjee S , Hauser F , Park J , Engineer C , Liu A , Ha T , Parker JE , Gassmann W , Schroeder JI |
| Ref : Plant Cell , 24 :5177 , 2012 |
| Abstract : |
| PubMedSearch : Kim_2012_Plant.Cell_24_5177 |
| PubMedID: 23275581 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity - Rietz_2011_New.Phytol_191_107 |
| Author(s) : Rietz S , Stamm A , Malonek S , Wagner S , Becker D , Medina-Escobar N , Vlot AC , Feys BJ , Niefind K , Parker JE |
| Ref : New Phytol , 191 :107 , 2011 |
| Abstract : |
| PubMedSearch : Rietz_2011_New.Phytol_191_107 |
| PubMedID: 21434927 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| Author(s) : Wagner S , Rietz S , Parker JE , Niefind K |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011 |
| Abstract : |
| PubMedSearch : Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245 |
| PubMedID: 21301097 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 |
| Title : SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus - Zhu_2011_PLoS.Pathog_7_e1002318 |
| Author(s) : Zhu S , Jeong RD , Venugopal SC , Lapchyk L , Navarre D , Kachroo A , Kachroo P |
| Ref : PLoS Pathog , 7 :e1002318 , 2011 |
| Abstract : |
| PubMedSearch : Zhu_2011_PLoS.Pathog_7_e1002318 |
| PubMedID: 22072959 |
| Gene_locus related to this paper: arath-PAD4 , arath-T17F15.50 |
| Title : Arabidopsis thaliana genes encoding defense signaling and recognition proteins exhibit contrasting evolutionary dynamics - Caldwell_2009_Genetics_181_671 |
| Author(s) : Caldwell KS , Michelmore RW |
| Ref : Genetics , 181 :671 , 2009 |
| Abstract : |
| PubMedSearch : Caldwell_2009_Genetics_181_671 |
| PubMedID: 19064707 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1 - Pegadaraju_2007_Plant.J_52_332 |
| Author(s) : Pegadaraju V , Louis J , Singh V , Reese JC , Bautor J , Feys BJ , Cook G , Parker JE , Shah J |
| Ref : Plant J , 52 :332 , 2007 |
| Abstract : |
| PubMedSearch : Pegadaraju_2007_Plant.J_52_332 |
| PubMedID: 17725549 |
| Gene_locus related to this paper: arath-PAD4 |
| Title : Plant immunity: the EDS1 regulatory node - Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| Author(s) : Wiermer M , Feys BJ , Parker JE |
| Ref : Curr Opin Plant Biol , 8 :383 , 2005 |
| Abstract : |
| PubMedSearch : Wiermer_2005_Curr.Opin.Plant.Biol_8_383 |
| PubMedID: 15939664 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601 |
| Author(s) : Feys BJ , Wiermer M , Bhat RA , Moisan LJ , Medina-Escobar N , Neu C , Cabral A , Parker JE |
| Ref : Plant Cell , 17 :2601 , 2005 |
| Abstract : |
| PubMedSearch : Feys_2005_Plant.Cell_17_2601 |
| PubMedID: 16040633 |
| Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 , arath-T17F15.50 |
| Title : Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4 - Feys_2001_EMBO.J_20_5400 |
| Author(s) : Feys BJ , Moisan LJ , Newman MA , Parker JE |
| Ref : EMBO Journal , 20 :5400 , 2001 |
| Abstract : |
| PubMedSearch : Feys_2001_EMBO.J_20_5400 |
| PubMedID: 11574472 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |
| Title : Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling - Jirage_1999_Proc.Natl.Acad.Sci.U.S.A_96_13583 |
| Author(s) : Jirage D , Tootle TL , Reuber TL , Frost LN , Feys BJ , Parker JE , Ausubel FM , Glazebrook J |
| Ref : Proc Natl Acad Sci U S A , 96 :13583 , 1999 |
| Abstract : |
| PubMedSearch : Jirage_1999_Proc.Natl.Acad.Sci.U.S.A_96_13583 |
| PubMedID: 10557364 |
| Gene_locus related to this paper: arath-PAD4 |
| Title : Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes - Parker_1996_Plant.Cell_8_2033 |
| Author(s) : Parker JE , Holub EB , Frost LN , Falk A , Gunn ND , Daniels MJ |
| Ref : Plant Cell , 8 :2033 , 1996 |
| Abstract : |
| PubMedSearch : Parker_1996_Plant.Cell_8_2033 |
| PubMedID: 8953768 |
| Gene_locus related to this paper: arath-eds1 , arath-PAD4 |