arath-PAD4

Arabidopsis thaliana (Mouse-ear cress) PAD4 lipase 61.0 kda protein EDS9 At3g52430 AtPAD4 (phytoalexin-deficient 4)

Comment

The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-PAD4) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance.EDS1 can dimerize and interact with PAD4 and SAG101 (arath-At5g14930) Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1\/EDS1\/SAG101 and ADR1\/EDS1\/PAD4) mediate TNL receptor defence signalling.

Relationship

Family : Plant_lipase_EDS1-like

Block : L

Position in NCBI Life Tree : Arabidopsis thaliana

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N E

Molecular evidence

Sequence

Peptide

MDDCRFETSE LQASVMISTP LFTDSWSSCN TANCNGSIKI HDIAGITYVA IPAVSMIQLG NLVGLPVTGD VLFPGLSSDE PLPMVDAAIL KLFLQLKIKE GLELELLGKK LVVITGHSTG GALAAFTALW LLSQSSPPSF RVFCITFGSP LLGNQSLSTS ISRSRLAHNF CHVVSIHDLV PRSSNEQFWP FGTYLFCSDK GGVCLDNAGS VRLMFNILNT TATQNTEEHQ RYGHYVFTLS HMFLKSRSFL GGSIPDNSYQ AGVALAVEAL GFSNDDTSGV LVKECIETAT RIVRAPILRS AELANELASV LPARLEIQWY KDRCDASEEQ LGYYDFFKRY SLKRDFKVNM SRIRLAKFWD TVIKMVETNE LPFDFHLGKK WIYASQFYQL LAEPLDIANF YKNRDIKTGG HYLEGNRPKR YEVIDKWQKG VKVPEECVRS RYASTTQDTC FWAKLEQAKE WLDEARKESS DPQRRSLLRE KIVPFESYAN TLVTKKEVSL DVKAKNSSYS VWEANLKEFK CKMGYENEIE MVVDESDAME T

References (18)

Title : Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity - Dongus_2022_Plant.J__
Author(s) : Dongus JA , Bhandari DD , Penner E , Lapin D , Stolze SC , Harzen A , Patel M , Archer L , Dijkgraaf L , Shah J , Nakagami H , Parker JE
Ref : Plant J , : , 2022
PubMedID: 35324052
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : PopP2 interacts with PAD4 in an acetyltransferase activity-dependent manner and affects plant immunity - Huh_2022_Plant.Signal.Behav__2017631
Author(s) : Huh SU
Ref : Plant Signal Behav , :2017631 , 2022
PubMedID: 34978271
Gene_locus related to this paper: arath-PAD4

Title : Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity - Huang_2022_Science_377_eabq3297
Author(s) : Huang S , Jia A , Song W , Hessler G , Meng Y , Sun Y , Xu L , Laessle H , Jirschitzka J , Ma S , Xiao Y , Yu D , Hou J , Liu R , Sun H , Liu X , Han Z , Chang J , Parker JE , Chai J
Ref : Science , 377 :eabq3297 , 2022
PubMedID: 35857645
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity - Sun_2021_Nat.Commun_12_3335
Author(s) : Sun X , Lapin D , Feehan JM , Stolze SC , Kramer K , Dongus JA , Rzemieniewski J , Blanvillain-Baufume S , Harzen A , Bautor J , Derbyshire P , Menke FLH , Finkemeier I , Nakagami H , Jones JDG , Parker JE
Ref : Nat Commun , 12 :3335 , 2021
PubMedID: 34099661
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors - Lapin_2019_Plant.Cell_31_2430
Author(s) : Lapin D , Kovacova V , Sun X , Dongus JA , Bhandari D , von Born P , Bautor J , Guarneri N , Rzemieniewski J , Stuttmann J , Beyer A , Parker JE
Ref : Plant Cell , 31 :2430 , 2019
PubMedID: 31311833
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity - Wagner_2013_Cell.Host.Microbe_14_619
Author(s) : Wagner S , Stuttmann J , Rietz S , Guerois R , Brunstein E , Bautor J , Niefind K , Parker JE
Ref : Cell Host Microbe , 14 :619 , 2013
PubMedID: 24331460
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : Natural variation in small molecule-induced TIR-NB-LRR signaling induces root growth arrest via EDS1- and PAD4-complexed R protein VICTR in Arabidopsis - Kim_2012_Plant.Cell_24_5177
Author(s) : Kim TH , Kunz HH , Bhattacharjee S , Hauser F , Park J , Engineer C , Liu A , Ha T , Parker JE , Gassmann W , Schroeder JI
Ref : Plant Cell , 24 :5177 , 2012
PubMedID: 23275581
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Crystallization and preliminary crystallographic analysis of Arabidopsis thaliana EDS1, a key component of plant immunity, in complex with its signalling partner SAG101 - Wagner_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_245
Author(s) : Wagner S , Rietz S , Parker JE , Niefind K
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :245 , 2011
PubMedID: 21301097
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4

Title : SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus - Zhu_2011_PLoS.Pathog_7_e1002318
Author(s) : Zhu S , Jeong RD , Venugopal SC , Lapchyk L , Navarre D , Kachroo A , Kachroo P
Ref : PLoS Pathog , 7 :e1002318 , 2011
PubMedID: 22072959
Gene_locus related to this paper: arath-PAD4 , arath-T17F15.50

Title : Different roles of Enhanced Disease Susceptibility1 (EDS1) bound to and dissociated from Phytoalexin Deficient4 (PAD4) in Arabidopsis immunity - Rietz_2011_New.Phytol_191_107
Author(s) : Rietz S , Stamm A , Malonek S , Wagner S , Becker D , Medina-Escobar N , Vlot AC , Feys BJ , Niefind K , Parker JE
Ref : New Phytol , 191 :107 , 2011
PubMedID: 21434927
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Arabidopsis thaliana genes encoding defense signaling and recognition proteins exhibit contrasting evolutionary dynamics - Caldwell_2009_Genetics_181_671
Author(s) : Caldwell KS , Michelmore RW
Ref : Genetics , 181 :671 , 2009
PubMedID: 19064707
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Phloem-based resistance to green peach aphid is controlled by Arabidopsis PHYTOALEXIN DEFICIENT4 without its signaling partner ENHANCED DISEASE SUSCEPTIBILITY1 - Pegadaraju_2007_Plant.J_52_332
Author(s) : Pegadaraju V , Louis J , Singh V , Reese JC , Bautor J , Feys BJ , Cook G , Parker JE , Shah J
Ref : Plant J , 52 :332 , 2007
PubMedID: 17725549
Gene_locus related to this paper: arath-PAD4

Title : Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity - Feys_2005_Plant.Cell_17_2601
Author(s) : Feys BJ , Wiermer M , Bhat RA , Moisan LJ , Medina-Escobar N , Neu C , Cabral A , Parker JE
Ref : Plant Cell , 17 :2601 , 2005
PubMedID: 16040633
Gene_locus related to this paper: arath-At5g14930 , arath-eds1 , arath-PAD4 , arath-T17F15.50

Title : Plant immunity: the EDS1 regulatory node - Wiermer_2005_Curr.Opin.Plant.Biol_8_383
Author(s) : Wiermer M , Feys BJ , Parker JE
Ref : Curr Opin Plant Biol , 8 :383 , 2005
PubMedID: 15939664
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4 - Feys_2001_EMBO.J_20_5400
Author(s) : Feys BJ , Moisan LJ , Newman MA , Parker JE
Ref : EMBO Journal , 20 :5400 , 2001
PubMedID: 11574472
Gene_locus related to this paper: arath-eds1 , arath-PAD4

Title : Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana - Salanoubat_2000_Nature_408_820
Author(s) : Salanoubat M , Lemcke K , Rieger M , Ansorge W , Unseld M , Fartmann B , Valle G , Blocker H , Perez-Alonso M , Obermaier B , Delseny M , Boutry M , Grivell LA , Mache R , Puigdomenech P , de Simone V , Choisne N , Artiguenave F , Robert C , Brottier P , Wincker P , Cattolico L , Weissenbach J , Saurin W , Quetier F , Schafer M , Muller-Auer S , Gabel C , Fuchs M , Benes V , Wurmbach E , Drzonek H , Erfle H , Jordan N , Bangert S , Wiedelmann R , Kranz H , Voss H , Holland R , Brandt P , Nyakatura G , Vezzi A , D'Angelo M , Pallavicini A , Toppo S , Simionati B , Conrad A , Hornischer K , Kauer G , Lohnert TH , Nordsiek G , Reichelt J , Scharfe M , Schon O , Bargues M , Terol J , Climent J , Navarro P , Collado C , Perez-Perez A , Ottenwalder B , Duchemin D , Cooke R , Laudie M , Berger-Llauro C , Purnelle B , Masuy D , de Haan M , Maarse AC , Alcaraz JP , Cottet A , Casacuberta E , Monfort A , Argiriou A , Flores M , Liguori R , Vitale D , Mannhaupt G , Haase D , Schoof H , Rudd S , Zaccaria P , Mewes HW , Mayer KF , Kaul S , Town CD , Koo HL , Tallon LJ , Jenkins J , Rooney T , Rizzo M , Walts A , Utterback T , Fujii CY , Shea TP , Creasy TH , Haas B , Maiti R , Wu D , Peterson J , Van Aken S , Pai G , Militscher J , Sellers P , Gill JE , Feldblyum TV , Preuss D , Lin X , Nierman WC , Salzberg SL , White O , Venter JC , Fraser CM , Kaneko T , Nakamura Y , Sato S , Kato T , Asamizu E , Sasamoto S , Kimura T , Idesawa K , Kawashima K , Kishida Y , Kiyokawa C , Kohara M , Matsumoto M , Matsuno A , Muraki A , Nakayama S , Nakazaki N , Shinpo S , Takeuchi C , Wada T , Watanabe A , Yamada M , Yasuda M , Tabata S
Ref : Nature , 408 :820 , 2000
PubMedID: 11130713
Gene_locus related to this paper: arath-MES17 , arath-AT3G12150 , arath-At3g61680 , arath-AT3g62590 , arath-CXE12 , arath-eds1 , arath-SCP25 , arath-F1P2.110 , arath-F1P2.140 , arath-F11F8.28 , arath-F14D17.80 , arath-F16B3.4 , arath-SCP27 , arath-At3g50790 , arath-At3g05600 , arath-PAD4 , arath-At3g51000 , arath-SCP16 , arath-gid1 , arath-GID1B , arath-Q9LUG8 , arath-Q84JS1 , arath-Q9SFF6 , arath-q9m236 , arath-q9sr22 , arath-q9sr23 , arath-SCP7 , arath-SCP14 , arath-SCP15 , arath-SCP17 , arath-SCP36 , arath-SCP37 , arath-SCP39 , arath-SCP40 , arath-SCP49 , arath-T19F11.2

Title : Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling - Jirage_1999_Proc.Natl.Acad.Sci.U.S.A_96_13583
Author(s) : Jirage D , Tootle TL , Reuber TL , Frost LN , Feys BJ , Parker JE , Ausubel FM , Glazebrook J
Ref : Proc Natl Acad Sci U S A , 96 :13583 , 1999
PubMedID: 10557364
Gene_locus related to this paper: arath-PAD4

Title : Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes - Parker_1996_Plant.Cell_8_2033
Author(s) : Parker JE , Holub EB , Frost LN , Falk A , Gunn ND , Daniels MJ
Ref : Plant Cell , 8 :2033 , 1996
PubMedID: 8953768
Gene_locus related to this paper: arath-eds1 , arath-PAD4