arath-F14F8.240

Arabidopsis thaliana At5g15860(Mouse-ear cress) Isoprenylcysteine alpha-carbonyl methylesterase ICME

Comment

Catalyzes the demethylation of isoprenylcysteine methylesters. In vitro, is specific for N-acetyl-S-farnesyl-L-cysteine methyl ester (AFCme) and has low activity toward N-acetyl-S-geranyl-L-cysteine methyl ester (AGCme). Acts as a positive regulator of ABA signaling. May be involved in the demethylation and inactivation of isoprenylated negative regulators of abscisic acid (ABA) signaling. Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins

Relationship

Family : BD-FAE

Block : H

Position in NCBI Life Tree : Arabidopsis thaliana

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Viridiplantae N E > Streptophyta N E > Streptophytina N E > Embryophyta N E > Tracheophyta N E > Euphyllophyta N E > Spermatophyta N E > Magnoliophyta N E > Mesangiospermae N E > eudicotyledons N E > Gunneridae N E > Pentapetalae N E > rosids N E > malvids N E > Brassicales N E > Brassicaceae N E > Camelineae N E > Arabidopsis N E > Arabidopsis thaliana N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MHSPLQTQQP EQRCWPMTST VSEIEEVLPD EDSDRTTLLN GEPLRRRVSG KSPVDEGPRR IFRQQSFGRD IGHAAAETYL ITGLSFKLLR YLGLSMDDKI TCPYMLCYAS YAWLSSRLDL YLPSNNDGLK PVVVFVTGGA WIIGWLLVNK FMFANLVLIF RYKAWGSLLG MQLAERDIIV ACLDYRNFPQ GTISDMVTDA SQGISFVCNN ISAFGGDPNR IYLMGQSAGA HIAACALLEQ ATKELKGESI SWTVSQIKAY FGLSGGYNLY KLVDHFHNRG LYRSIFLSIM EGEESFEKFS PEVRLKDPVV GKAASLLPPI ILFHGSSDYS IPCDESKTFT DALQAVGAKA ELVLYSGKTH TDLFLQDPLR GGKDELFDDI VSVIHAEDND GLTKDSLAPP RKRLVPELLL KLAREISPF

References (6)

Title : Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana - Lan_2010_BMC.Plant.Biol_10_212
Author(s) : Lan P , Li W , Wang H , Ma W
Ref : BMC Plant Biol , 10 :212 , 2010
PubMedID: 20868530
Gene_locus related to this paper: arath-F14F8.240 , arath-F16B3.4

Title : Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis - Huizinga_2008_Plant.Cell_20_2714
Author(s) : Huizinga DH , Omosegbon O , Omery B , Crowell DN
Ref : Plant Cell , 20 :2714 , 2008
PubMedID: 18957507
Gene_locus related to this paper: arath-F14F8.240 , arath-F16B3.4

Title : Prenylcysteine methylesterase in Arabidopsis thaliana - Deem_2006_Gene_380_159
Author(s) : Deem AK , Bultema RL , Crowell DN
Ref : Gene , 380 :159 , 2006
PubMedID: 16870359
Gene_locus related to this paper: arath-F14F8.240 , arath-F16B3.4

Title : Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana - Tabata_2000_Nature_408_823
Author(s) : Tabata S , Kaneko T , Nakamura Y , Kotani H , Kato T , Asamizu E , Miyajima N , Sasamoto S , Kimura T , Hosouchi T , Kawashima K , Kohara M , Matsumoto M , Matsuno A , Muraki A , Nakayama S , Nakazaki N , Naruo K , Okumura S , Shinpo S , Takeuchi C , Wada T , Watanabe A , Yamada M , Yasuda M , Sato S , de la Bastide M , Huang E , Spiegel L , Gnoj L , O'Shaughnessy A , Preston R , Habermann K , Murray J , Johnson D , Rohlfing T , Nelson J , Stoneking T , Pepin K , Spieth J , Sekhon M , Armstrong J , Becker M , Belter E , Cordum H , Cordes M , Courtney L , Courtney W , Dante M , Du H , Edwards J , Fryman J , Haakensen B , Lamar E , Latreille P , Leonard S , Meyer R , Mulvaney E , Ozersky P , Riley A , Strowmatt C , Wagner-McPherson C , Wollam A , Yoakum M , Bell M , Dedhia N , Parnell L , Shah R , Rodriguez M , See LH , Vil D , Baker J , Kirchoff K , Toth K , King L , Bahret A , Miller B , Marra M , Martienssen R , McCombie WR , Wilson RK , Murphy G , Bancroft I , Volckaert G , Wambutt R , Dusterhoft A , Stiekema W , Pohl T , Entian KD , Terryn N , Hartley N , Bent E , Johnson S , Langham SA , McCullagh B , Robben J , Grymonprez B , Zimmermann W , Ramsperger U , Wedler H , Balke K , Wedler E , Peters S , van Staveren M , Dirkse W , Mooijman P , Lankhorst RK , Weitzenegger T , Bothe G , Rose M , Hauf J , Berneiser S , Hempel S , Feldpausch M , Lamberth S , Villarroel R , Gielen J , Ardiles W , Bents O , Lemcke K , Kolesov G , Mayer K , Rudd S , Schoof H , Schueller C , Zaccaria P , Mewes HW , Bevan M , Fransz P
Ref : Nature , 408 :823 , 2000
PubMedID: 11130714
Gene_locus related to this paper: arath-At5g11650 , arath-At5g16120 , arath-at5g18630 , arath-AT5G20520 , arath-At5g21950 , arath-AT5G27320 , arath-CXE15 , arath-F1N13.220 , arath-F14F8.240 , arath-q3e9e4 , arath-q8lae9 , arath-Q8LFB7 , arath-q9ffg7 , arath-q9fij5 , arath-Q9LVU7 , arath-q66gm8 , arath-SCPL34 , arath-B9DFR3 , arath-a0a1p8bcz0

Title : Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence features of the regions of 1,081,958 bp covered by seventeen physically assigned P1 and TAC clones. -
Author(s) : Asamizu E , Sato S , Kaneko T , Nakamura Y , Kotani H , Miyajima N , Tabata S
Ref : DNA Research , 5 :379 , 1998
PubMedID: 10048488
Gene_locus related to this paper: arath-At5g14930 , arath-at5g18630 , arath-AT5G19050 , arath-At5g24180 , arath-AT5G24190 , arath-At5g24200 , arath-F2G14.100 , arath-F6H11.120 , arath-F9G14.280 , arath-F14F8.240 , arath-HNL , arath-At5g14310