Aspergillus novofumigatus (strain IBT 16806). Novofumigatonin biosynthesis cluster protein D
Alpha\/beta hydrolase\; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety\; The alpha\/beta hydrolase nvfD acts as an epimerase that converts fumigatonoid A to its C-5' epimer, which then undergoes spontaneous or nvfD-catalyzed lactonization
Family : 6_AlphaBeta_hydrolase
Block : X
Position in NCBI Life Tree : Aspergillus novofumigatus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Aspergillus N E > Aspergillus novofumigatus N EMLKPAIIIVP GALHRPEHYQ GIVSRLHKLQ YEAVAVSMPS LSSSPPQPTW TEDVEAIRKA IFKFSESGQD VVLVGHSYSG ILISEASKGL SRKDLPHGEG AVVRLIYMCA IAVPVGESLT GQLEPRTPQE VEAFREEGSI SLLDADKVRD VLYNKCEPKV ADWAISLLGK QPVTTMSTPA THAAWLEIPS TYLICEDDLA VPECVQLRMA KQGNGAFDIV RCQEGHAPCL SNPDLVVRMI RNAAGEAIEI
| Title : Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation - Matsuda_2018_Nat.Commun_9_2587 |
| Author(s) : Matsuda Y , Bai T , Phippen CBW , Nodvig CS , Kjaerbolling I , Vesth TC , Andersen MR , Mortensen UH , Gotfredsen CH , Abe I , Larsen TO |
| Ref : Nat Commun , 9 :2587 , 2018 |
| Abstract : |
| PubMedSearch : Matsuda_2018_Nat.Commun_9_2587 |
| PubMedID: 29968715 |
| Gene_locus related to this paper: aspn1-nvfd |
| Title : Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species - Kjaerbolling_2018_Proc.Natl.Acad.Sci.U.S.A_115_E753 |
| Author(s) : Kjaerbolling I , Vesth TC , Frisvad JC , Nybo JL , Theobald S , Kuo A , Bowyer P , Matsuda Y , Mondo S , Lyhne EK , Kogle ME , Clum A , Lipzen A , Salamov A , Ngan CY , Daum C , Chiniquy J , Barry K , LaButti K , Haridas S , Simmons BA , Magnuson JK , Mortensen UH , Larsen TO , Grigoriev IV , Baker SE , Andersen MR |
| Ref : Proc Natl Acad Sci U S A , 115 :E753 , 2018 |
| Abstract : |
| PubMedSearch : Kjaerbolling_2018_Proc.Natl.Acad.Sci.U.S.A_115_E753 |
| PubMedID: 29317534 |
| Gene_locus related to this paper: 9euro-a0a0f8xhh7 , 9euro-a0a2t5ll04 , aspn1-nvfd |