pig-PLE1

Sus scrofa (Pig). Carboxylic ester hydrolase. Pig Liver esterase PLE1

Comment

PLE1 prefers to hydrolyse esters with a large alcohol group and a small acyl group. || There are at least 6 isoenzyme (may be different genes Q9TS80 PLE1 A5A4F5 PLE3). Isoenzymes of pig-liver esterase reveal striking differences in enantioselectivities Hummel et al. 2007<\/A>. Polyisoprenylated. methylated protein methyl esterase (PMPMEase). Pig liver esterase 5 (PLE5) (pig-a9gyw6<\/A>) is the isoenzyme crystallized (5FV4<\/A>)

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Sus scrofa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Suina N E > Suidae N E > Sus N E > Sus scrofa N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

No Interpro

No Pfam

No UniProt

No PIRSF

No SUPERFAM

Sequence

Peptide

MWLLPLVLTS LASSATWGQP ASPPVVDTAQ GRVLGKYVSL EGLAQPVAVF LGVPFAKPPL GSLRFAPPQP AEPWSFVKNT TSYPPMCCQG PIGGQMLSDL FTNRKERLTP EFSEDCLYLN IYTPADLTKR GRLPVMVWIH GGGLVVGGAS TYDGLALAAH ENVVVVAIQY RPGIWGFFST GDEHSRGNWG HLDQVAALHW VQENIANFGG DPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA LPVGLVRKDM KAAAKQIAVL AGCKTTTSAV FVHCLRQKSE DELLDLTLKM KFFALDLHGD PRESHPFLPT VVDGVLLPKM PEEILAEKDF NTVPYIVGIN KQEFGWLLPT MMGFPLSEGK LDQKTATSLL WKSYPIANIP EELTPVATDK YLGGTDDPVK KKDLFLDLMG DVVFGVPSVT VARQHRDAGA PTYMYEFQYR PSFSSDKKPK TVIGDHGDEL FSVFGAPFLK GDAPEEEVSL SKTVMKFWAN FARSGNPNGE GLPHWPMYDQ EEGYLQIGVN TQAAKRLKGE EVAFWNDLLS KEAAKKPPKI KHAEL

References (5)

Title : Pig Liver Esterases Hydrolyze Endocannabinoids and Promote Inflammatory Response - Zhou_2021_Front.Immunol_12_670427
Author(s) : Zhou Q , Yan B , Sun W , Chen Q , Xiao Q , Xiao Y , Wang X , Shi D
Ref : Front Immunol , 12 :670427 , 2021
Abstract :
PubMedSearch : Zhou_2021_Front.Immunol_12_670427
PubMedID: 34079552
Gene_locus related to this paper: pig-PLE1 , pig-a0a1s6l967

Title : Asymmetric Synthesis of Dihydropinidine Enabled by Concurrent Multienzyme Catalysis and a Biocatalytic Alternative to Krapcho Dealkoxycarbonylation - Alvarenga_2020_ACS.Catal_10_1607
Author(s) : Alvarenga N , Payer SE , Petermeier P , Kohlfuerst C , Porto ALM , Schrittwieser JH , Kroutil W
Ref : ACS Catal , 10 :1607 , 2020
Abstract :
PubMedSearch : Alvarenga_2020_ACS.Catal_10_1607
PubMedID:
Gene_locus related to this paper: pig-PLE1

Title : Breed Differences in Pig Liver Esterase (PLE) between Tongcheng (Chinese Local Breed) and Large White Pigs - Xiao_2018_Sci.Rep_8_16364
Author(s) : Xiao Q , Zhou Q , Yang L , Tian Z , Wang X , Xiao Y , Shi D
Ref : Sci Rep , 8 :16364 , 2018
Abstract :
PubMedSearch : Xiao_2018_Sci.Rep_8_16364
PubMedID: 30397234
Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-PLE1 , pig-a0a1s6l948 , pig-a0a1s6l959 , pig-a0a1s6l967

Title : Third-Generation Sequencing and Analysis of Four Complete Pig Liver Esterase Gene Sequences in Clones Identified by Screening BAC Library - Zhou_2016_PLoS.One_11_e0163295
Author(s) : Zhou Q , Sun W , Liu X , Wang X , Xiao Y , Bi D , Yin J , Shi D
Ref : PLoS ONE , 11 :e0163295 , 2016
Abstract :
PubMedSearch : Zhou_2016_PLoS.One_11_e0163295
PubMedID: 27695062
Gene_locus related to this paper: pig-EST1 , pig-PLE1 , pig-a0a1s6l948 , pig-a0a1s6l959 , pig-a0a1s6l967

Title : FRET-based fluorescence probes for hydrolysis study and pig liver esterase activity - Yi_2008_Tetrahedron_64_8947
Author(s) : Yi L , Cao L , Liu L , Xi Z
Ref : Tetrahedron , 64 :8947 , 2008
Abstract :
PubMedSearch : Yi_2008_Tetrahedron_64_8947
PubMedID:
Gene_locus related to this paper: pig-PLE1