pig-dpp4

Sus scrofa dipeptidylpeptidase IV (90-286)

Comment

Belongs to peptidase family s9B || Trembl Q866G2 by Weber A., Gerhartz B., Treichel S., Demuth H.-U. differs by 2 aa

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Sus scrofa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Suina N E > Suidae N E > Sus N E > Sus scrofa N E

Database

Sequence

Peptide

KTPWKVLLGL LGIAALVTVI TVPVVLLNKG NDAAADSRRT YTLTDYLKST FRVKFYTLQW ISDHEYLYKQ ENNILLFNAE YGNSSIFLEN STFDELGYST NDYSVSPDRQ FILFEYNYVK QWRHSYTASY DIYDLNKRQL ITEERIPNNT QWITWSPVGH KLAYVWNNDI YVKNEPNLSS QRITWTGKEN VIYNGVTDWV YEEEVFSAYS ALWWSPNGTF LAYAQFNDTE VPLIEYSFYS DESLQYPKTV RIPYPKAGAE NPTVKFFVVD TRTLSPNASV TSYQIVPPAS VLIGDHYLCG VTWVTEERIS LQWIRRAQNY SIIDICDYDE STGRWISSVA RQHIEISTTG WVGRFRPAEP HFTSDGNSFY KIISNEEGYK HICHFQTDKS NCTFITKGAW EVIGIEALTS DYLYYISNEH KGMPGGRNLY RIQLNDYTKV TCLSCELNPE RCQYYSASFS NKAKYYQLRC FGPGLPLYTL HSSSSDKELR VLEDNSALDK MLQDVQMPSK KLDVINLHGT KFWYQMILPP HFDKSKKYPL LIEVYAGPCS QKVDTVFRLS WATYLASTEN IIVASFDGRG SGYQGDKIMH AINRRLGTFE VEDQIEATRQ FSKMGFVDDK RIAIWGWSYG GYVTSMVLGA GSGVFKCGIA VAPVSKWEYY DSVYTERYMG LPTPEDNLDY YRNSTVMSRA ENFKQVEYLL IHGTADDNVH FQQSAQLSKA LVDAGVDFQT MWYTDEDHGI ASNMAHQHIY THMSHFLKQC FSLP

References (5)

Title : Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure - Schnapp_2016_J.Med.Chem_59_7466
Author(s) : Schnapp G , Klein T , Hoevels Y , Bakker RA , Nar H
Ref : Journal of Medicinal Chemistry , 59 :7466 , 2016
PubMedID: 27438064
Gene_locus related to this paper: pig-dpp4

Title : Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV - Engel_2006_J.Mol.Biol_355_768
Author(s) : Engel M , Hoffmann T , Manhart S , Heiser U , Chambre S , Huber R , Demuth HU , Bode W
Ref : Journal of Molecular Biology , 355 :768 , 2006
PubMedID: 16330047
Gene_locus related to this paper: pig-dpp4

Title : The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors - Nordhoff_2006_Bioorg.Med.Chem.Lett_16_1744
Author(s) : Nordhoff S , Cerezo-Galvez S , Feurer A , Hill O , Matassa VG , Metz G , Rummey C , Thiemann M , Edwards PJ
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1744 , 2006
PubMedID: 16376544
Gene_locus related to this paper: pig-dpp4

Title : The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism - Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063
Author(s) : Engel M , Hoffmann T , Wagner L , Wermann M , Heiser U , Kiefersauer R , Huber R , Bode W , Demuth HU , Brandstetter H
Ref : Proc Natl Acad Sci U S A , 100 :5063 , 2003
PubMedID: 12690074
Gene_locus related to this paper: pig-dpp4

Title : Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig chromosome 15q21 - Thomsen_1993_Mamm.Genome_4_604
Author(s) : Thomsen PD , Qvist H , Marklund L , Andersson L , Sjostrom H and
Ref : Mamm.Genom , 4 :604 , 1993
PubMedID: 7903569
Gene_locus related to this paper: pig-dpp4