pig-dpp4

Sus scrofa dipeptidylpeptidase IV (90-286)

Comment

Belongs to peptidase family s9B || Trembl Q866G2 by Weber A., Gerhartz B., Treichel S., Demuth H.-U. differs by 2 aa

Relationship

Block : X

Position in NCBI Life Tree : Sus scrofa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Suina N E > Suidae N E > Sus N E > Sus scrofa N E

Molecular evidence

No mutation

1ORV - Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) 1ORW - Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor 2AJ8 - Porcine dipeptidyl peptidase IV (CD26) in complex with 7-Benzyl-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-purine-2,6-dione (BDPX) 2AJB - Porcine dipeptidyl peptidase IV (CD26) in complex with the tripeptide tert-butyl-Gly-L-Pro-L-Ile (tBu-GPI) 2AJC - Porcine dipeptidyl peptidase IV (CD26) in complex with 4-(2-Aminoethyl)-benzene sulphonyl fluoride (AEBSF) 2AJD - Porcine dipeptidyl peptidase IV (CD26) in complex with L-Pro-boro-L-Pro (boroPro) 2BUA - Crystal Structure Of Porcine Dipeptidyl Peptidase IV (Cd26) in complex with a low molecular weight inhibitor 2BUC - Crystal structure of porcine dipeptidyl peptidase IV (CD26) in complex with a tetrahydroisoquinoline inhibitor 5LLS - Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione 7XNM - Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex

No kinetic

No disease

No substrate

1-Phenylcyclopentanemethylamine 6Z8 AEBSF BDPX ILAPPER Pro-boropro Tetrahydroisoquinoline-derivative p-Iodo-Phe-Pyr-CN tBu-GPI

Database

AY198323 X73276

P22411

Sequence

Peptide

KTPWKVLLGL LGIAALVTVI TVPVVLLNKG NDAAADSRRT YTLTDYLKST FRVKFYTLQW ISDHEYLYKQ ENNILLFNAE YGNSSIFLEN STFDELGYST NDYSVSPDRQ FILFEYNYVK QWRHSYTASY DIYDLNKRQL ITEERIPNNT QWITWSPVGH KLAYVWNNDI YVKNEPNLSS QRITWTGKEN VIYNGVTDWV YEEEVFSAYS ALWWSPNGTF LAYAQFNDTE VPLIEYSFYS DESLQYPKTV RIPYPKAGAE NPTVKFFVVD TRTLSPNASV TSYQIVPPAS VLIGDHYLCG VTWVTEERIS LQWIRRAQNY SIIDICDYDE STGRWISSVA RQHIEISTTG WVGRFRPAEP HFTSDGNSFY KIISNEEGYK HICHFQTDKS NCTFITKGAW EVIGIEALTS DYLYYISNEH KGMPGGRNLY RIQLNDYTKV TCLSCELNPE RCQYYSASFS NKAKYYQLRC FGPGLPLYTL HSSSSDKELR VLEDNSALDK MLQDVQMPSK KLDVINLHGT KFWYQMILPP HFDKSKKYPL LIEVYAGPCS QKVDTVFRLS WATYLASTEN IIVASFDGRG SGYQGDKIMH AINRRLGTFE VEDQIEATRQ FSKMGFVDDK RIAIWGWSYG GYVTSMVLGA GSGVFKCGIA VAPVSKWEYY DSVYTERYMG LPTPEDNLDY YRNSTVMSRA ENFKQVEYLL IHGTADDNVH FQQSAQLSKA LVDAGVDFQT MWYTDEDHGI ASNMAHQHIY THMSHFLKQC FSLP

References (7)

Title : Purification, crystal structural characterization of porcine kidney dipeptidyl peptidase IV (PkDPP-IV) and its interaction with oyster derived inhibitory peptide ILAPPER - Li_2025_Int.J.Biol.Macromol__140047

Author(s) : Li WY , Chen H , Lin D , Zhang T , Chen YL , Jin T , Cao MJ

Ref : Int J Biol Macromol , :140047 , 2025

Abstract :

PubMedSearch : Li_2025_Int.J.Biol.Macromol__140047

PubMedID: 39828169

Gene_locus related to this paper: pig-dpp4

Title : Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion - Shi_2024_J.Virol__e0075324

Author(s) : Shi J , Hu S , Wei H , Zhang L , Lan Y , Guan J , Zhao K , Gao F , He W , Li Z

Ref : J Virol , :e0075324 , 2024

Abstract :

PubMedSearch : Shi_2024_J.Virol__e0075324

PubMedID: 38829136

Gene_locus related to this paper: mouse-dpp4 , pig-dpp4

Title : Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure - Schnapp_2016_J.Med.Chem_59_7466

Author(s) : Schnapp G , Klein T , Hoevels Y , Bakker RA , Nar H

Ref : Journal of Medicinal Chemistry , 59 :7466 , 2016

Abstract :

PubMedSearch : Schnapp_2016_J.Med.Chem_59_7466

PubMedID: 27438064

Gene_locus related to this paper: pig-dpp4

Title : Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV - Engel_2006_J.Mol.Biol_355_768

Author(s) : Engel M , Hoffmann T , Manhart S , Heiser U , Chambre S , Huber R , Demuth HU , Bode W

Ref : Journal of Molecular Biology , 355 :768 , 2006

Abstract :

PubMedSearch : Engel_2006_J.Mol.Biol_355_768

PubMedID: 16330047

Gene_locus related to this paper: pig-dpp4

Title : The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors - Nordhoff_2006_Bioorg.Med.Chem.Lett_16_1744

Author(s) : Nordhoff S , Cerezo-Galvez S , Feurer A , Hill O , Matassa VG , Metz G , Rummey C , Thiemann M , Edwards PJ

Ref : Bioorganic & Medicinal Chemistry Lett , 16 :1744 , 2006

Abstract :

PubMedSearch : Nordhoff_2006_Bioorg.Med.Chem.Lett_16_1744

PubMedID: 16376544

Gene_locus related to this paper: pig-dpp4

Title : The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism - Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063

Author(s) : Engel M , Hoffmann T , Wagner L , Wermann M , Heiser U , Kiefersauer R , Huber R , Bode W , Demuth HU , Brandstetter H

Ref : Proc Natl Acad Sci U S A , 100 :5063 , 2003

Abstract :

PubMedSearch : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063

PubMedID: 12690074

Gene_locus related to this paper: pig-dpp4

Title : Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig chromosome 15q21 - Thomsen_1993_Mamm.Genome_4_604

Author(s) : Thomsen PD , Qvist H , Marklund L , Andersson L , Sjostrom H and

Ref : Mamm.Genom , 4 :604 , 1993

Abstract :

PubMedSearch : Thomsen_1993_Mamm.Genome_4_604

PubMedID: 7903569

Gene_locus related to this paper: pig-dpp4

pig-dpp4

Comment

Relationship

Molecular evidence

Mutation (0)

Structure (10)

Kinetic (0)

Disease (0)

Substrate (0)

Inhibitor (9)

Database

Genbank (2)

Interpro (1)

Pfam (1)

UniProt (1)

PIRSF (1)

SUPERFAM (1)

Sequence

Peptide

References (7)

1. Purification, crystal structural characterization of porcine kidney dipeptidyl peptidase IV (PkDPP-IV) and its interaction with oyster derived inhibitory peptide ILAPPER - Li_2025_Int.J.Biol.Macromol__140047

2. Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion - Shi_2024_J.Virol__e0075324

3. Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure - Schnapp_2016_J.Med.Chem_59_7466

4. Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV - Engel_2006_J.Mol.Biol_355_768

5. The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors - Nordhoff_2006_Bioorg.Med.Chem.Lett_16_1744

6. The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism - Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063

7. Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig chromosome 15q21 - Thomsen_1993_Mamm.Genome_4_604