Plasmodium_subtelomeric_PST-A
Relationship
Comment
These proteins represent a paralogous family of genes found in Plasmodium falciparum and Plasmodium yoelii that are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii. TIGRFAMs TIGR01607 (PST-A). Close sequences of other Apicomplexa species were included
Database
Interpro : IPR006494 Plasmodium subtelomeric PST-A PST_A
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12146 Hydrolase_4
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9apic-BdFE1 | Babesia duncani bifunctional Alpha-Beta hydrolase fold\/Serine aminopeptidase BdWA1_002357 BdFE1 fosinopril esterase | Babesia duncani |
| babbo-a7as90 | Babesia bovis Lysophospholipase, putative | Babesia bovis |
| plaba-q4ymx5 | Plasmodium berghei (strain Anka) Putative uncharacterized protein | Plasmodium berghei |
| plaba-q4z215 | Plasmodium berghei (strain Anka) Phospholipase, putative | Plasmodium berghei |
| plach-q4x817 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4xb56 | Plasmodium chabaudi phospholipase, putative (fragment) | Plasmodium chabaudi |
| plach-q4xd64 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4xfc7 | Plasmodium chabaudi phospholipase, putative (fragment) | Plasmodium chabaudi |
| plach-q4xm16 | Plasmodium chabaudi phospholipase, putative (fragment) | Plasmodium chabaudi |
| plach-q4xmx8 | Plasmodium chabaudi phospholipase, putative | Plasmodium chabaudi |
| plach-q4xmy0 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4xsf9 | Plasmodium chabaudi phospholipase, putative (fragment) | Plasmodium chabaudi |
| plach-q4xsg4 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4xvc8 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4xxy1 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4y0k9 | Plasmodium chabaudi Lysophospholipase-like protein, putative | Plasmodium chabaudi |
| plach-q4y5u9 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| plach-q4y638 | Plasmodium chabaudi phospholipase, putative (fragment) | Plasmodium chabaudi |
| plaf7-c0h4q4 | Plasmodium falciparum (isolate 3D7) PF3D7_0731800 Alpha\/beta hydrolase, putative | Plasmodium falciparum |
| plafa-PF07.0005 | Plasmodium falciparum (isolate 3D7) PF3D7_0702200 lysophospholipases-like protein, putative | Plasmodium falciparum |
| plafa-PF07.0040 | Plasmodium falciparum (isolate 3D7) PF3D7_0709700 lysophospholipase-like protein, PfPARE Prodrug activation and resistance esterase | Plasmodium falciparum |
| plafa-PF10.0018 | Plasmodium falciparum (isolate 3D7) hypothetical protein PF3D7_1001400 PfXL | Plasmodium falciparum |
| plafa-PF10.0020 | Plasmodium falciparum (isolate 3D7) PF10_0020 PF3D7_1001600 hypothetical protein exported lipase 2, PfXL2 containing the export element (PEXEL) | Plasmodium falciparum |
| plafa-PF10.0379 | Plasmodium falciparum (isolate 3D7) PF3D7_1038900 phospholipase, putative PfMAGLLP | Plasmodium falciparum |
| plafa-PF13.0153 | Plasmodium falciparum (isolate 3D7) PF3D7_1328500 hypothetical protein MLPL | Plasmodium falciparum |
| plafa-PF14.0017 | Plasmodium falciparum (isolate 3D7) PF3D7_1401500 lysophospholipase, putative | Plasmodium falciparum |
| plafa-PF14.0737 | Plasmodium falciparum (isolate 3D7) PF3D7_1476700 lysophospholipase, putative Psta1 | Plasmodium falciparum |
| plafa-PF14.0738 | Plasmodium falciparum (isolate 3D7) PF3D7_1476800 lysophospholipase, putative Psta2 | Plasmodium falciparum |
| plafa-PFI1775W | Plasmodium falciparum (isolate 3D7) PF3D7_0936700 hypothetical protein | Plasmodium falciparum |
| plafa-PFI1800W | Plasmodium falciparum (isolate 3D7) PF3D7_0937200 enzyme, putative | Plasmodium falciparum |
| plafa-PFL2530W | Plasmodium falciparum (isolate 3D7) PF3D7_1252600 hypothetical protein | Plasmodium falciparum |
| plafa-w7jws4 | Plasmodium falciparum enzyme putative PF3D7_0102400 S33H | Plasmodium falciparum |
| plakh-b3kz42 | Plasmodium knowlesi (strain H) Lysophospholipase-like protein | Plasmodium knowlesi |
| plakh-b3l0y4 | Plasmodium knowlesi (strain H) Lysophospholipase-like protein, putative | Plasmodium knowlesi |
| plakh-b3l1r3 | Plasmodium knowlesi (strain H) Phospholipase, putative | Plasmodium knowlesi |
| plakh-b3l336 | Plasmodium knowlesi (strain H) Putative uncharacterized protein | Plasmodium knowlesi |
| plakh-b3l8u5 | Plasmodium knowlesi (strain H) Putative uncharacterized protein | Plasmodium knowlesi |
| plavi-a5kcq0 | Plasmodium vivax PST-A protein | Plasmodium vivax |
| plavs-a5k5e4 | Plasmodium vivax (strain Salvador I) PST-A protein | Plasmodium vivax |
| plavs-a5k686 | Plasmodium vivax (strain Salvador I) PST-A protein | Plasmodium vivax |
| plavs-a5k7t5 | Plasmodium vivax (strain Salvador I) PST-A protein | Plasmodium vivax |
| plavs-a5kaa1 | Plasmodium vivax (strain Salvador I) PST-A protein | Plasmodium vivax |
| plavs-a5kas6 | Plasmodium vivax (strains Salvador I\; PST-A) PST-A protein | Plasmodium vivax |
| plavs-a5kcm2 | Plasmodium vivax (strain Salvador I) PST-A protein | Plasmodium vivax |
| playo-q7rbj8 | Plasmodium yoelii yoelii lysophospholipase | Plasmodium yoelii yoelii |
| playo-q7rdk4 | Plasmodium yoelii yoelii hypothetical protein | Plasmodium yoelii yoelii |
| playo-q7rgi9 | Plasmodium yoelii yoelii hypothetical protein | Plasmodium yoelii yoelii |
| playo-q7rn16 | Plasmodium yoelii yoelii Immediate early protein homolog-related | Plasmodium yoelii yoelii |
| playo-q7rpk0 | Plasmodium yoelii yoelii putative phospholipase | Plasmodium yoelii yoelii |
| playo-q7rq49 | Plasmodium yoelii yoelii hypothetical protein | Plasmodium yoelii yoelii |
| playo-q7rq68 | Plasmodium yoelii yoelii hypothetical protein | Plasmodium yoelii yoelii |
| thean-q4ub48 | Theileria annulata Putative uncharacterized protein | Theileria annulata |
| thean-q4uhj9 | Theileria annulata Putative uncharacterized protein | Theileria annulata |
| thepa-q4n315 | Theileria parva Putative uncharacterized protein | Theileria parva |
| thepa-q4n803 | Theileria parva Putative uncharacterized protein | Theileria parva |
| toxgo-b9pz13 | Toxoplasma gondii Putative uncharacterized protein | Toxoplasma gondii |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| neocl-f0vd97 | Neospora caninum (strain Liverpool) Putative lysophospholipase | Neospora caninum |
| plach-q4y2f5 | Plasmodium chabaudi Phospholipase, putative | Plasmodium chabaudi |
| toxgo-b9qg70 | Toxoplasma gondii Lysophospholipase, putative | Toxoplasma gondii |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| 4-methylumbelliferyl-caprylate | (4-methyl-2-oxochromen-7-yl) octanoate | bactc-lipas plafa-PF10.0379 fusox-a0a1d3s5h0 |
| Arachidonoyl-1-thioglycerol | S-(2,3-dihydroxypropyl) (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate | human-MGLL plafa-PF10.0379 |
| Fosinopril | (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid | 9apic-BdFE1 human-CES1 |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| JW651 | 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate | human-MGLL plafa-PF10.0379 |
| KML29 | 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate | human-MGLL plafa-PF10.0379 |
| MJN110 | (2,5-dioxopyrrolidin-1-yl) 4-[bis(4-chlorophenyl)methyl]piperazine-1-carboxylate | human-MGLL plafa-PF10.0379 |
| Orlistat | [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate | human-DAGLA human-DAGLB human-PNLIP human-FASN mycs2-a0r619 human-PNLIPRP2 human-ABHD16A myctu-a85c myctu-Rv3822 plafa-PF10.0379 staau-lipas human-CES2 myctu-Rv3802c |
| Sal-A-alkyne | plafa-PF10.0020 plafa-PF07.0040 plafa-a0a143zya4 plafa-PF10.0379 plafa-PF13.0153 plaf7-q8iik5 plaf7-q8ii19 plafa-MAL8P1.138 | |
| Salinipostin-A | (3R,8aS)-5-butyl-3-oxo-3-pentadecoxy-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one | plafa-PF10.0020 plafa-PF07.0040 plafa-a0a143zya4 plafa-PF10.0379 plafa-PF13.0153 plaf7-q8iik5 plaf7-q8ii19 plafa-MAL8P1.138 |
References (1)
| Title : The Antimalarial Natural Product Salinipostin A Identifies Essential alpha\/beta Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites - Yoo_2020_Cell.Chem.Biol_27_143 |
| Author(s) : Yoo E , Schulze CJ , Stokes BH , Onguka O , Yeo T , Mok S , Gnadig NF , Zhou Y , Kurita K , Foe IT , Terrell SM , Boucher MJ , Cieplak P , Kumpornsin K , Lee MCS , Linington RG , Long JZ , Uhlemann AC , Weerapana E , Fidock DA , Bogyo M |
| Ref : Cell Chemical Biology , 27 :143 , 2020 |
| Abstract : |
| PubMedSearch : Yoo_2020_Cell.Chem.Biol_27_143 |
| PubMedID: 31978322 |
| Gene_locus related to this paper: plaf7-q8ii19 , plafa-a0a143zya4 , plaf7-q8iik5 , plafa-MAL8P1.38 , plafa-PF07.0040 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF13.0153 |