Gene_locus Report for: burca-q1bk56 Burkholderia cenocepacia Uncharacterized protein
Comment
Other strains: Burkholderia cenocepacia (strain AU 1054; HI2424; ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315); MC0-3; H111), only n-term Pfam A DUF2235 43 331 Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Bacteria: N E > Proteobacteria: N E > Betaproteobacteria: N E > Burkholderiales: N E > Burkholderiaceae: N E > Burkholderia: N E > Burkholderia cepacia complex: N E > Burkholderia cenocepacia: N E 6_AlphaBeta_hydrolase :
burcj-b4e794 ,
9burk-q4lhe4 Burkholderia cenocepacia HI2424 (and AU 1054)(strain 383) (MC0-3) PC184 alpha/beta hydrolase fold ,
burca-q1bg74 Burkholderia cenocepacia alpha/beta hydrolase fold precursor ,
burca-q1bga6 Burkholderia cenocepacia (strain AU 1054) alpha/beta hydrolase fold precursor ,
burca-q1big9 Burkholderia cenocepacia alpha/beta hydrolase fold ,
burca-q1bqp8 Burkholderia cenocepacia (strains AU 1054; MC0-3; HI2424) alpha/beta hydrolase fold ,
burca-q1bqu5 Burkholderia cenocepacia (strains AU 1054; HI2424; 383; PC184; MC03; J2315 / LMG 16656) alpha/beta hydrolase fold ,
burca-q1buj2 Burkholderia cenocepacia (strain AU 1054) (strain HI2424) (strain MC0-3) alpha/beta hydrolase fold ,
burcc-b1k1n7 Burkholderia cenocepacia (strains MC0-3; PC184) Putative uncharacterized protein ,
burcc-b1k5m2 Burkholderia cenocepacia, Burkholderia cepacia, alpha/beta hydrolase fold precursor ,
burch-a0axx4 Burkholderia cenocepacia, Burkholderia sp., Burkholderia cepacia, Putative uncharacterized protein ,
burch-a0ayi0 Burkholderia cenocepacia (strain HI2424) (strain AU 1054) (strain 383) (strain PC184) (strain MC0-3) alpha/beta hydrolase fold ,
burch-a0azs8 Burkholderia cenocepacia (strain HI2424) (strain AU 1054) (strain 383) (strain MC0-3) alpha/beta hydrolase fold ,
burch-a0b1b4 Burkholderia cenocepacia (strains HI2424; AU 1054; 383) alpha/beta hydrolase fold ,
burch-a0b2h1 Burkholderia cenocepacia (strain HI2424) (strain AU 1054) PC184 MC0-3 alpha/beta hydrolase fold ,
burch-a0b203 Burkholderia cenocepacia (strains HI2424; AU 1054)Burkholderia ambifaria AMMD hydrolase, alpha/beta hydrolase fold family Thioesterase ,
burch-a0b353 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia cenocepacia, Burkholderia multivorans alpha/beta hydrolase fold ,
burch-a0k8m5 Burkholderia cenocepacia (strain HI2424) (and AU 1054) (strain 383) (strain MC0-3) alpha/beta hydrolase fold ,
burch-a0kcy9 Burkholderia cenocepacia (strains HI2424; AU 1054; MC0-3) Putative secreted protein .
abh_upf0017 :
burcj-b4ebz5 Burkholderia cepacia, Burkholderia cenocepacia, Burkholderia multivorans, Burkholderia sp. Putative hydrolase .
abh_upf00227 :
burca-q1bzb3 Burkholderia cenocepacia, Burkholderia sp., Burkholderia cepacia hypothetical protein .
AcoC_BiotinLipoyl-ABH :
burcc-b1jtb7 Burkholderia cenocepacia (strain MC0-3) (strain AU 1054) (strain HI2424) (PC 184)alpha/beta hydrolase fold .
AlphaBeta_hydrolase :
burch-a0k8n4 Burkholderia cenocepacia (HI2424; MC0-3; AU 1054) putative uncharacterized protein .
Bacterial_lip_FamI.2 :
burch-a0az26 Burkholderia cenocepacia, Burkholderia ambifaria (Burkholderia cepacia) Triacylglycerol lipase .
Carboxymethylbutenolide_lactonase :
burca-q1bk71 Burkholderia cenocepacia; Pseudomonas pyrrocinia; Burkholderia cepacia; Burkholderia multivorans; Burkholderia dolosa; Burkholderia sp. 3-oxoadipate enol-lactonase (EC 3.1.1.24) .
Carboxypeptidase_S10 :
burca-q1bl79 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia ambifaria, Burkholderia vietnamiensis, Burkholderia sp. Peptidase S10, serine carboxypeptidase ,
burca-q1bqx1 Burkholderia cenocepacia putative carboxypeptidase ,
burca-q1byn5 Burkholderia cenocepacia probable carboxypeptidase protein precursor ,
burca-q1bza9 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia sp., Burkholderia ambifaria, Burkholderia vietnamiensis, Burkholderia multivorans, probable carboxypeptidase protein precursor .
Carb_B_Bacteria :
burch-a0k359 Burkholderia cenocepacia (strain HI2424) carboxylesterase, type b precursor ,
9burk-a0a088uau9 Burkholderia cenocepacia. Carboxylic ester hydrolase ,
9burk-a0a088uel2 Burkholderia cenocepacia; Burkholderia pseudomultivorans. Carboxylic ester hydrolase .
CFTR-inhibitory-factor_Cif :
burch-a0az59 ,
burch-a0b0f8 .
Dienelactone_hydrolase :
9burk-q44yv1 Burkholderia cenocepacia (strains AU 1054; HI2424) Burkholderia ambifaria AMMD carboxymethylenebutenolidase (EC 3.1.1.45) ,
burca-q1bly2 Burkholderia cenocepacia, Burkholderia multivorans, Burkholderia ambifaria, Carboxymethylenebutenolidase (EC 3.1.1.45) ,
burch-a0kcm6 Burkholderia cenocepacia carboxymethylenebutenolidase (EC 3.1.1.45) ,
burch-a0ke87 Burkholderia cenocepacia, Burkholderia ambifaria, carboxymethylenebutenolidase (EC 3.1.1.45) .
Duf_3141 :
burcc-b1k8j3 Burkholderia cenocepacia (strains MC0-3; AU 1054; HI2424; PC184) phb de-polymerase-like , C-terminal precursor .
Epoxide_hydrolase :
9burk-q4lts8 Burkholderia cenocepacia (strains HI2424; AU 1054; 383) epoxide hydrolase, n-terminal ,
burca-q1bp72 Burkholderia cenocepacia Alpha/beta hydrolase fold protein ,
burca-q1bxs9 Burkholderia cenocepacia (strain AU 1054; HI2424) Burkholderia cepacia (strain J2315 / LMG 16656) Alpha/beta hydrolase fold protein ,
burcc-b1k6g4 Burkholderia cenocepacia, Burkholderia ambifaria alpha/beta hydrolase fold precursor ,
burcc-b1k6n9 Burkholderia cenocepacia (strain MC0-3) Alpha/beta hydrolase fold ,
burcc-b1kb7 Burkholderia cenocepacia MC0-3 AU 1054 (and HI2424) (strain 383) PC184 alpha/beta hydrolase fold ,
burch-a0axw6 Burkholderia cenocepacia, Burkholderia sp., Burkholderia ambifaria, Burkholderia dolosa, Burkholderia cepacia, Epoxide hydrolase domain protein ,
burch-a0b227 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia ambifaria Short-chain dehydrogenase/reductase SDR ,
burch-a0kbk8 Burkholderia cenocepacia,Burkholderia cepacia, Burkholderia ambifaria AMMD Alpha/beta hydrolase fold protein ,
burch-a0kbq9 Burkholderia cenocepacia (strains HI2424; AU 1054; MC0-3) Burkholderia ambifaria AMMD Alpha/beta hydrolase fold protein ,
burch-a0kdr9 Burkholderia cenocepacia (strain HI2424) (and strain AU 1054) Alpha/beta hydrolase fold .
GTSAGmotif :
burcj-b4ek59 Burkholderia cenocepacia (Burkholderia cepacia) Putative esterase .
Haloacetate_dehalogenase :
burch-a0kd06 Burkholderia cenocepacia (strains HI2424; AU 1054; MC0-3; PC184; J2315 / LMG 16656) Burkholderia ambifaria AMMD Alpha/beta hydrolase fold protein .
Haloalkane_dehalogenase-HLD1 :
burch-a0azu1 Burkholderia cenocepacia (strains AU 1054; HI2424; MC0-3) Burkholderia sp. (strain 383) Haloalkane_dehalogenase HLDIII .
Haloperoxidase :
burca-q1bqn9 Burkholderia cenocepacia (strains AU 1054; MC0-3; HI2424) alpha/beta hydrolase fold ,
burca-q1br69 Burkholderia cenocepacia (strains AU 1054; MC0-3; HI2424) alpha/beta hydrolase fold ,
burca-q1bvi6 Burkholderia cenocepacia (strains AU 1054; MC0-3; HI2424; PC184) alpha/beta hydrolase fold ,
burch-a0kc67 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia multivorans, Non-heme chloroperoxidase (Chloride peroxidase) (CPO-F)(Chloroperoxidase F) ,
burch-a0kd32 Burkholderia cenocepacia (strains HI2424; AU 1054; MC0-3; PC184) chloride peroxidase precursor (EC 1.11.1.10) ,
burch-a0kd47 Burkholderia cenocepacia (strains AU 1054; HI2424; MC0-3; PC184) alpha/beta hydrolase fold .
HNLyase_Bact :
burch-a0b440 Burkholderia cenocepacia; Burkholderia cepacia; Burkholderia dolosa alpha/beta hydrolase fold Esterase EstC .
Homoserine_transacetylase :
burca-metx Burkholderia cenocepacia, Burkholderia sp., Burkholderia cepacia, Burkholderia ambifaria, Burkholderia dolosa, Burkholderia multivorans homoserine o-acetyltransferase (EC 2.3.1.31) .
Hormone-sensitive_lipase_like :
9burk-q4lje4 Burkholderia cenocepacia (strains HI2424; AU 1054) Burkholderia ambifaria AMMD putative lipase/esterase protein ,
9burk-q4lqn7 Burkholderia cenocepacia (strains HI2424; AU 1054) esterase/lipase/thioesterase ,
9burk-q4lx78 Burkholderia cenocepacia (strain HI2424) Burkholderia ambifaria AMMD flavin-containing monooxygenase fmo precursor ,
9burk-q44xk8 Burkholderia cenocepacia, Burkholderia ambifaria, esterase/lipase/thioesterase ,
burca-q1bq91 Burkholderia cenocepacia (strains AU 1054; HI2424) lipolytic enzyme ,
burcc-b1kby5 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia dolosa, Burkholderia sp., Burkholderia ambifaria, Burkholderia vietnamiensis, esterase/lipase/thioesterase ,
burch-a0ax41 Burkholderia cenocepacia, Burkholderia dolosa lipase ,
9burk-a0a142p9e4 Burkholderia cenocepacia Lipolytic protein .
Hydrolase_RBBP9_YdeN :
9burk-q4lwn4 Burkholderia cenocepacia HI2424 hypothetical protein ,
9burk-q45a89 Burkholderia cenocepacia AU 1054 Burkholderia ambifaria AMMD hypothetical protein ,
9burk-q457i8 Burkholderia cenocepacia (strains AU 1054; HI2424) hypothetical protein .
LYsophospholipase_carboxylesterase :
burch-a0azh6 Burkholderia cenocepacia, Burkholderia ambifaria AMMD phospholipase/carboxylesterase .
Monoglyceridelipase_lysophospholip :
9burk-q4lwk2 Burkholderia cenocepacia (strains HI2424; AU 1054; 383) Burkholderia ambifaria AMMD hypothetical protein ,
burch-a0k5n4 Burkholderia cenocepacia, Burkholderia sp., Alpha/beta hydrolase fold protein .
NFM-deformylase :
9burk-a0u8m3 Burkholderia cenocepacia, Pseudomonas pyrrocinia, Mumia flava, Burkholderia sp. alpha/beta hydrolase fold .
OHBut_olig_hydro_put :
burcj-b4ecv6 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)). Probable exported hydrolase .
PHB_depolymerase_PhaZ :
9burk-q459w5 Burkholderia cenocepacia (strains AU 1054; HI2424) phb de-polymerase, c-terminal ,
burca-q1blj2 Burkholderia cenocepacia, Burkholderia ambifaria, polyhydroxyalkanoate depolymerase ,
burs3-q39e56 Burkholderia cenocepacia, Burkholderia sp., Burkholderia multivorans, polyhydroxyalkanoate depolymerase .
Proline_iminopeptidase :
burch-a0azm5 Burkholderia cenocepacia, Burkholderia cepacia, Burkholderia sp., peptidase s33, proline iminopeptidase 1 (EC 3.4.11.5) ,
burch-a0b2i1 Burkholderia cenocepacia (strain HI2424; AU 1054; PC184)(EC 3.4.11.5) Prolyl aminopeptidase, Serine peptidase, MEROPS family S33 ,
burcc-b1k6y2 Burkholderia cenocepacia (strain MC0-3). Prolyl aminopeptidase ,
burcj-b4ehl7 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)). Putative proline iminopeptidase .
S9N_PPCE_Peptidase_S9 :
burca-q1bhv9 Burkholderia cenocepacia prolyl oligopeptidase,active site and n-terminal beta-propeller .
Tannase :
burca-q1bjv3 Burkholderia cenocepacia Burkholderia ambifaria, Burkholderia cepacia, feruloyl esterase precursor (EC 3.1.1.73) .
Thioesterase :
burca-q1bq44 Burkholderia cenocepacia, thioesterase .
UCP031982 :
burch-a0b1h8 Burkholderia cenocepacia (strain HI2424; MC0-3; PC184; AU 1054) Dienelactone hydrolase-like protein .
UCP037442 :
9burk-q27ip7 Burkholderia cenocepacia (strains hlpa; AU 1054; HI2424; MC0-3; PC184; J2315/LMG16656) hypothetical protein ,
burch-a0b0j3 Burkholderia cenocepacia, Burkholderia sp. Alpha/beta hydrolase-like protein .
VirJ :
burca-q1bnp3 Burkholderia cenocepacia, Burkholderia ambifaria, Burkholderia dolosa, virulence precursor ,
9burk-a0a071mfb3 Burkholderia cenocepacia; Burkholderia seminalis. Virulence factor ,
9burk-a0a088ujy7 Burkholderia cenocepacia; Burkholderia pseudomultivorans; Burkholderia sp.. Cutinase family protein ,
9burk-a0a109ei83 Burkholderia cenocepacia; Burkholderia sp. Virulence factor .
Xaa-Pro-like_dom :
9burk-a0a071mdb4 Burkholderia cenocepacia. Acetyl xylan esterase Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
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(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Burkholderia cenocepacia AU 1054:
N ,
E .
Burkholderia cenocepacia HI2424:
N ,
E .
Burkholderia cenocepacia J2315:
N ,
E .
Burkholderia cenocepacia MC0-3:
N ,
E .
Burkholderia cenocepacia H111:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: burca-q1bk56 Colored MSA for Duf_2235 (raw)
MSNPPLIRRITDITPVEDSIRNGHREALDPLRVEQCKECPKPVWFTAFFD
GTGNNYGEDGNGSTDVAKTKYSNIAKLAMFAHVPFNKANPRTMGRYVEGV
GTPCSKVGDSGKGIDGALGMAAASKGEARIRWMLRELEKHVANHMPAVSQ
INVAAFGFSRGATEARAFVRMLTEQLAENIGGRLWWNKKNMKGMRPEVVV
YFMGILDTVASTGFGGSRLEKAAPYIVGAILGPVYGGMLHSIDKGGHAEW
ANDIRIPDYVRECVHYVASHEVREKFPGDSVREDQKLPSNCREVYYPGMH
SDVGGGYERNYQEGRTNELANVALNNLYIDAWKAGVPFREPKEIVESAGG
LFAISPELETAWNVYMGQ
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M S N P P L I R R I T D I T P V E D S I R N G H R E A L D P L R V E Q C K E C P K P V W F T A F F D G T G N N Y G E D G N G S T D V A K T K Y S N I A K L A M F A H V P F N K A N P R T M G R Y V E G V G T P C S K V G D S G K G I D G A L G M A A A S K G E A R I R W M L R E L E K H V A N H M P A V S Q I N V A A F G F S R G A T E A R A F V R M L T E Q L A E N I G G R L W W N K K N M K G M R P E V V V Y F M G I L D T V A S T G F G G S R L E K A A P Y I V G A I L G P V Y G G M L H S I D K G G H A E W A N D I R I P D Y V R E C V H Y V A S H E V R E K F P G D S V R E D Q K L P S N C R E V Y Y P G M H S D V G G G Y E R N Y Q E G R T N E L A N V A L N N L Y I D A W K A G V P F R E P K E I V E S A G G L F A I S P E L E T A W N V Y M G Q
Reference
Title: The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patientsHolden MT , Seth-Smith HM , Crossman LC , Sebaihia M , Bentley SD , Cerdeno-Tarraga AM , Thomson NR , Bason N , Quail MA and Parkhill J <22 more author(s)> Holden MT , Seth-Smith HM , Crossman LC , Sebaihia M , Bentley SD , Cerdeno-Tarraga AM , Thomson NR , Bason N , Quail MA , Sharp S , Cherevach I , Churcher C , Goodhead I , Hauser H , Holroyd N , Mungall K , Scott P , Walker D , White B , Rose H , Iversen P , Mil-Homens D , Rocha EP , Fialho AM , Baldwin A , Dowson C , Barrell BG , Govan JR , Vandamme P , Hart CA , Mahenthiralingam E , Parkhill J (- 22) Ref: Journal of Bacteriology, 191 :261, 2009 : PubMed Abstract ESTHER: Holden_2009_J.Bacteriol_191_261 PubMedSearch: Holden 2009 J.Bacteriol 191 261 PubMedID: 18931103 Gene_locus related to this paper: burcj-b4e794 ,
9burk-a0u8m3 ,
burcj-b4ek59 ,
burcj-b4ehl7 ,
burca-q1bk56 ,
burce-a0a088tsj6 ,
burcj-b4ecv6 Abstract
Bacterial infections of the lungs of cystic fibrosis (CF) patients cause major complications in the treatment of this common genetic disease. Burkholderia cenocepacia infection is particularly problematic since this organism has high levels of antibiotic resistance, making it difficult to eradicate; the resulting chronic infections are associated with severe declines in lung function and increased mortality rates. B. cenocepacia strain J2315 was isolated from a CF patient and is a member of the epidemic ET12 lineage that originated in Canada or the United Kingdom and spread to Europe. The 8.06-Mb genome of this highly transmissible pathogen comprises three circular chromosomes and a plasmid and encodes a broad array of functions typical of this metabolically versatile genus, as well as numerous virulence and drug resistance functions. Although B. cenocepacia strains can be isolated from soil and can be pathogenic to both plants and man, J2315 is representative of a lineage of B. cenocepacia rarely isolated from the environment and which spreads between CF patients. Comparative analysis revealed that ca. 21% of the genome is unique in comparison to other strains of B. cenocepacia, highlighting the genomic plasticity of this species. Pseudogenes in virulence determinants suggest that the pathogenic response of J2315 may have been recently selected to promote persistence in the CF lung. The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen.
Other Papers
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)). Putative hydrolase