Gene_locus Report for: cryne-q5kc00 Cryptococcus neoformans (Filobasidiella neoformans) (and var. neoformans B-3501A) peptidase, putative
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Basidiomycota: N E > Agaricomycotina: N E > Tremellomycetes: N E > Tremellales: N E > Cryptococcaceae: N E > Cryptococcus [Filobasidiella]: N E > Cryptococcus neoformans species complex: N E > Cryptococcus neoformans: N E 6_AlphaBeta_hydrolase :
cryne-q5kjw7 Cryptococcus neoformans var. neoformans JEC21 (and B-3501A) expressed protein ,
cryne-q5klu9 Cryptococcus neoformans var. neoformans JEC21 (and B-3501A) hypothetical protein .
A85-EsteraseD-FGH :
cryne-q5k7p6 Cryptococcus neoformans (Filobasidiella neoformans) carboxylesterase, putative .
ABHD13-BEM46 :
cryne-q5kip7 Cryptococcus neoformans (Filobasidiella neoformans) (and B-3501A) hypothetical protein .
abh_upf0017 :
cryne-q5ka03 Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus gattii (Cryptococcus bacillisporus) lipid metabolism-related protein, putative ,
crynj-q5kpe0 Cryptococcus neoformans (Filobasidiella neoformans) (Cryptococcus bacillisporus) protein, putative .
BD-FAE :
cryne-q5kfk6 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A) hypothetical protein .
Carboxypeptidase_S10 :
cryne-q5k9e7 Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus gattii hypothetical protein ,
cryne-q5ka24 Cryptococcus neoformans (Filobasidiella neoformans) hypothetical protein ,
cryne-q5key5 Cryptococcus neoformans (Filobasidiella neoformans) carboxypeptidase c, putative ,
cryne-q5khb0 Cryptococcus neoformans (Filobasidiella neoformans) kex1 protein, putative ,
cryne-q5kiu5 Cryptococcus neoformans (Filobasidiella neoformans) carboxypeptidase d, putative (EC 3.4.16.6) ,
cryne-q5kj56 Cryptococcus neoformans (Filobasidiella neoformans) carboxypeptidase d, putative ,
cryne-q5kjp9 Cryptococcus neoformans var. neoformans JEC21 carboxypeptidase d, putative .
CGI-58_ABHD5_ABHD4 :
cryne-q5khb9 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A) hypothetical protein .
Dienelactone_hydrolase :
cryne-q5k9y9 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A ) cytoplasm protein, putative ,
cryne-q5kbw4 Cryptococcus neoformans (Filobasidiella neoformans) ( and var. neoformans B-3501A ) hypothetical protein ,
cryne-q5kni1 Cryptococcus neoformans var. neoformans JEC21 (and strain B-3501A) carboxymethylenebutenolidase, putative .
Duf_676 :
cryne-q5kky1 Cryptococcus neoformans (Filobasidiella neoformans) triacylglycerol lipase, putative ,
cryne-Q5KCH9 Cryptococcus neoformans var. neoformans B-3501A hypothetical protein ,
cryne-q55ta1 Cryptococcus neoformans var. neoformans B-3501A hypothetical protein .
Duf_726 :
cryne-q5kkz7 Cryptococcus neoformans (Filobasidiella neoformans) Putative uncharacterized protein ,
cryne-q55v86 Cryptococcus neoformans (Filobasidiella neoformans) Putative uncharacterized protein .
FSH1 :
cryne-q5kjh3 Cryptococcus neoformans (Filobasidiella neoformans) expressed protein ,
cryne-q5kjh4 Cryptococcus neoformans (Filobasidiella neoformans); Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus) hypothetical protein .
Fungal_carboxylesterase_lipase :
cryne-q5k9p3 Cryptococcus neoformans var. neoformans JEC21 hypothetical protein ,
cryne-q5kei3 Cryptococcus neoformans var. neoformans var. grubii hypothetical protein .
Fusarinine_C_esterase_sidJ :
cryne-q5knq0 Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus) . hypothetical protein .
Homoserine_transacetylase :
cryne-q5k8p2 Cryptococcus neoformans (Filobasidiella neoformans) (and B-3501A) homoserine o-acetyltransferase, putative ,
cryne-q5kgq3 Cryptococcus neoformans (Filobasidiella neoformans) (and B-3501A) hypothetical protein .
Hormone-sensitive_lipase_like :
cryne-q5k7g1 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A) expressed protein ,
cryne-q5k7h2 Cryptococcus neoformans (Filobasidiella neoformans)(and var. neoformans B-3501A) expressed protein ,
cryne-q5kbu4 Cryptococcus neoformans (Filobasidiella neoformans) and (var. neoformans B-3501A) endoplasmic reticulum protein, putative ,
cryne-q5kei7 Cryptococcus neoformans (Filobasidiella neoformans) (and var. neoformans B-3501A) hypothetical protein ,
cryne-q5ker2 Cryptococcus neoformans (Filobasidiella neoformans) hypothetical protein ,
cryne-q5kh37 Cryptococcus neoformans (Filobasidiella neoformans) hypothetical protein ,
cryne-q5kme9 Cryptococcus neoformans var. neoformans JEC21(and var. neoformans B-3501A) hormone-sensitive lipase, putative ,
cryne-q5knw0 Cryptococcus neoformans var. neoformans JEC21 and var. neoformans B-3501Ahypothetical protein .
LIDHydrolase :
cryne-q560g9 Cryptococcus neoformans (Filobasidiella neoformans) Putative uncharacterized protein .
Lipase_3 :
cryne-q5kl13 Cryptococcus neoformans var. neoformans JEC21 (and B-3501A) lipase, putative .
LYsophospholipase_carboxylesterase :
cryne-apth1 Cryptococcus neoformans (Filobasidiella neoformans) ( and var. neoformans B-3501A) acyl-protein thioesterase-1, putative .
Monoglyceridelipase_lysophospholip :
cryne-q5km63 Cryptococcus neoformans var. neoformans, Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus) lysophospholipase .
PAF-Acetylhydrolase :
cryne-q5kec5 Cryptococcus neoformans (Filobasidiella neoformans)(and strain B-3501A) (EC 3.1.1.47) .
Palmitoyl-protein_thioesterase :
cryne-q5kq08 Cryptococcus neoformans var. neoformans JEC21 (and strain B-3501A)palmitoyl-protein thioesterase, putative .
PC-sterol_acyltransferase :
cryne-q5k8s0 Cryptococcus neoformans (Filobasidiella neoformans) (and strain B-3501A) phospholipid:diacylglycerol acyltransferase, putative .
PGAP1 :
cryne-q5kf48 Cryptococcus neoformans (Filobasidiella neoformans) er-associated protein catabolism-related protein, putative .
PPase_methylesterase_euk :
cryne-ppme1 Cryptococcus neoformans (Filobasidiella neoformans) (and B-3501A) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) .
Prolylcarboxypeptidase :
cryne-q5kfz0 Cryptococcus neoformans (Filobasidiella neoformans) hypothetical protein .
Prolyl_oligopeptidase_S9 :
cryne-q5k987 Cryptococcus neoformans (Filobasidiella neoformans) (and strain B-3501A ) hypothetical protein .
S9N_PPCE_Peptidase_S9 :
cryne-q5kat4 Cryptococcus neoformans (Filobasidiella neoformans) (and var. neoformans B-3501A) prolyl endopeptidase, putative (EC 3.4.21.26) ,
cryne-q5kav3 Cryptococcus neoformans (Filobasidiella neoformans) (and var. neoformans B-3501A) hypothetical protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
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(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Cryptococcus neoformans var. neoformans JEC21:
N ,
E .
Cryptococcus neoformans var. neoformans:
N ,
E .
Cryptococcus neoformans var. neoformans B-3501A:
N ,
E .
Cryptococcus neoformans var. grubii H99:
N ,
E .
Cryptococcus neoformans var. grubii c45:
N ,
E .
Cryptococcus neoformans var. grubii Bt85:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: cryne-q5kc00 Colored MSA for Prolyl_oligopeptidase_S9 (raw)
MRATVLTLLGLSASAWATPAPFTVEDMLAAPRPFPAIASPDKQHAIAVVD
YWEPRDDSMRREAYLATLNRPEVKHPISLFNTTPSAAADFFWLDDVTIAY
LDGSNLFSYPVEYAFSQSNFKPKHNPPRSPRHQKILSFPHGVNPTSLQYE
ASTKTLAFTGQVWSDGSFYQTRHHDKLYEKKRDSAQVYDDLMVRHWDTWR
VSGKVWTLGVVKLININDEWAELDNDINKHHKRRAEFINILNGTDLVSQT
DPIDAGSYSISSEHIAVAVKPPYLQTATHTREDIYLFPLPSSYDSASILP
KHVTPHAHGAISEIKFSPDGKKLSWLEMKKDGYESDRRVVVVYDLMSGKS
ERWTEVWDRSPKSISWAVDSQSIFLLAEFRGRTLPYHLTHPNHLPTPLLF
NGTTVSLTPLNETDILIARQSFRTPTVEWILTLPDPAEDGNAVGDGDGDK
IPAVEPLRQLTRWNEHFIRGRLDVQTGEEFWFKGAEGKDVMGWALKPRGW
KPDQKAKYPLAFLIHGGPQSAWDDSWSTRWNPALFAAQGYFVVAINPTGS
TGYGQEFTDAIQGDWGGKPFKDLLAGYHYVLENYPEIDPERTAGLGASYG
GYMVNWINGHNDHFGFKALVCHDGVFDTVTTFFSTEEIYFPTQDFAGTPW
TNRATYEKWNPVNHVIEWNTPELVIQGGKDYRLENSQGLGAFTALQLQGV
PSRFVYFPDENHWILKPHNSIKWHHEVFRWLEEWIGKPTDESEAFVVQRE
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M R A T V L T L L G L S A S A W A T P A P F T V E D M L A A P R P F P A I A S P D K Q H A I A V V D Y W E P R D D S M R R E A Y L A T L N R P E V K H P I S L F N T T P S A A A D F F W L D D V T I A Y L D G S N L F S Y P V E Y A F S Q S N F K P K H N P P R S P R H Q K I L S F P H G V N P T S L Q Y E A S T K T L A F T G Q V W S D G S F Y Q T R H H D K L Y E K K R D S A Q V Y D D L M V R H W D T W R V S G K V W T L G V V K L I N I N D E W A E L D N D I N K H H K R R A E F I N I L N G T D L V S Q T D P I D A G S Y S I S S E H I A V A V K P P Y L Q T A T H T R E D I Y L F P L P S S Y D S A S I L P K H V T P H A H G A I S E I K F S P D G K K L S W L E M K K D G Y E S D R R V V V V Y D L M S G K S E R W T E V W D R S P K S I S W A V D S Q S I F L L A E F R G R T L P Y H L T H P N H L P T P L L F N G T T V S L T P L N E T D I L I A R Q S F R T P T V E W I L T L P D P A E D G N A V G D G D G D K I P A V E P L R Q L T R W N E H F I R G R L D V Q T G E E F W F K G A E G K D V M G W A L K P R G W K P D Q K A K Y P L A F L I H G G P Q S A W D D S W S T R W N P A L F A A Q G Y F V V A I N P T G S T G Y G Q E F T D A I Q G D W G G K P F K D L L A G Y H Y V L E N Y P E I D P E R T A G L G A S Y G G Y M V N W I N G H N D H F G F K A L V C H D G V F D T V T T F F S T E E I Y F P T Q D F A G T P W T N R A T Y E K W N P V N H V I E W N T P E L V I Q G G K D Y R L E N S Q G L G A F T A L Q L Q G V P S R F V Y F P D E N H W I L K P H N S I K W H H E V F R W L E E W I G K P T D E S E A F V V Q R E
Reference
Title: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformansLoftus BJ , Fung E , Roncaglia P , Rowley D , Amedeo P , Bruno D , Vamathevan J , Miranda M , Anderson IJ and Hyman RW <44 more author(s)> Loftus BJ , Fung E , Roncaglia P , Rowley D , Amedeo P , Bruno D , Vamathevan J , Miranda M , Anderson IJ , Fraser JA , Allen JE , Bosdet IE , Brent MR , Chiu R , Doering TL , Donlin MJ , D'Souza CA , Fox DS , Grinberg V , Fu J , Fukushima M , Haas BJ , Huang JC , Janbon G , Jones SJ , Koo HL , Krzywinski MI , Kwon-Chung JK , Lengeler KB , Maiti R , Marra MA , Marra RE , Mathewson CA , Mitchell TG , Pertea M , Riggs FR , Salzberg SL , Schein JE , Shvartsbeyn A , Shin H , Shumway M , Specht CA , Suh BB , Tenney A , Utterback TR , Wickes BL , Wortman JR , Wye NH , Kronstad JW , Lodge JK , Heitman J , Davis RW , Fraser CM , Hyman RW (- 44) Ref: Science, 307 :1321, 2005 : PubMed Abstract ESTHER: Loftus_2005_Science_307_1321 PubMedSearch: Loftus 2005 Science 307 1321 PubMedID: 15653466 Gene_locus related to this paper: cryne-apth1 ,
cryne-ppme1 ,
cryne-q5k7g1 ,
cryne-q5k7h2 ,
cryne-q5k7p6 ,
cryne-q5k8p2 ,
cryne-q5k8s0 ,
cryne-q5k9e7 ,
cryne-q5k9p3 ,
cryne-q5k9y9 ,
cryne-q5k721 ,
cryne-q5k987 ,
cryne-q5ka03 ,
cryne-q5ka24 ,
cryne-q5ka58 ,
cryne-q5kat4 ,
cryne-q5kav3 ,
cryne-q5kbu4 ,
cryne-q5kbw4 ,
cryne-q5kc00 ,
cryne-q5kec5 ,
cryne-q5kei3 ,
cryne-q5kei7 ,
cryne-q5ker2 ,
cryne-q5key5 ,
cryne-q5kf48 ,
cryne-q5kfk6 ,
cryne-q5kfz0 ,
cryne-q5kgq3 ,
cryne-q5kh37 ,
cryne-q5khb0 ,
cryne-q5khb9 ,
cryne-q5kip7 ,
cryne-q5kiu5 ,
cryne-q5kj56 ,
cryne-q5kjf8 ,
cryne-q5kjh3 ,
cryne-q5kjp9 ,
cryne-q5kjw7 ,
cryne-q5kky1 ,
cryne-q5kkz7 ,
cryne-q5kl13 ,
cryne-q5klu9 ,
cryne-q5km63 ,
cryne-q5kme9 ,
cryne-q5kni1 ,
cryne-q5knq0 ,
cryne-q5knr2 ,
cryne-q5knw0 ,
cryne-q5kq08 ,
cryne-Q5KCH9 ,
cryne-q55ta1 ,
cryne-q5kjh4 ,
crynj-q5knp8 ,
crynj-q5kpe0 Abstract
Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.
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