ACHE-GSK-3-27g
AChE: IC50 = 51.1 nM; GSK-3beta: IC50 = 89.3 nM
General
Type : GSK-3 kinase inhibitor, Derivative of Tacrine, Multitarget
Chemical_Nomenclature : 2-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptylamino]-6-(3-fluoropyridin-4-yl)-3-methylpyrimidin-4-one
Canonical SMILES : CN1C(=O)C=C(N=C1NCCCCCCCNC2=C3CCCCC3=NC4=C2C=CC(=C4)Cl)C5=C(C=NC=C5)F
InChI : InChI=1S\/C30H34ClFN6O\/c1-38-28(39)18-27(21-13-16-33-19-24(21)32)37-30(38)35-15-8-4-2-3-7-14-34-29-22-9-5-6-10-25(22)36-26-17-20(31)11-12-23(26)29\/h11-13,16-19H,2-10,14-15H2,1H3,(H,34,36)(H,35,37)
InChIKey : LLNZCYJMOMQYIU-UHFFFAOYSA-N
Other name(s) :
MW : 549.1
Formula : C30H34ClFN6O
CAS_number :
PubChem : 154632938
UniChem : LLNZCYJMOMQYIU-UHFFFAOYSA-N
Target
Families : ACHE-GSK-3-27g ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE\/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease - Yao_2021_J.Med.Chem__ |
| Author(s) : Yao H , Uras G , Zhang P , Xu S , Yin Y , Liu J , Qin S , Li X , Allen S , Bai R , Gong Q , Zhang H , Zhu Z , Xu J |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Yao_2021_J.Med.Chem__ |
| PubMedID: 34024109 |