Cholinesterase
Relationship
Comment
Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly
Database
Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B , IPR050654 Acetylcholinesterase-related enzyme
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : PR00878
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Acetylcholine | 2-(Acetyloxy)-N,N,N,-trimethylethanaminium | bunfa-ACHE eleel-ACHE chick-ACHE human-ACHE human-BCHE mouse-ACHE mouse-BCHE ratno-ACHE torca-ACHE torma-ACHE |
| Acetylthiocholine | 2-acetylsulfanylethyl(trimethyl)azanium | bunfa-ACHE eleel-ACHE chick-ACHE human-ACHE human-BCHE mouse-ACHE mouse-BCHE ratno-ACHE torca-ACHE torma-ACHE |
| O-Nitrophenylacetate | (2-nitrophenyl) acetate |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| 11a-quinoxaline | N-(3-aminoquinoxalin-2-yl)-4-(piperidin-1-ylmethyl)benzamide | |
| 18-E100 | 1-[7-(4-chlorophenoxy)heptyl]azepane | |
| BYYT-25 | 5,6-dimethoxy-2-[4-(pyrrolidin-1-ylmethyl)phenoxy]-2,3-dihydroinden-1-one | |
| Canadine | 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene | |
| Methylene-blue-carboline-2 | 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]-3-(2-ethyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)propan-1-one | |
| Thalictricavine | (1R,21S)-16,17-dimethoxy-21-methyl-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene | |
| UW-MD-71 | (7-(3-(piperidin-1-yl)propoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline |
References (5)
| Title : Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules - Comoletti_2020_Neuropharmacol_184_108381 |
| Author(s) : Comoletti D , Trobiani L , Chatonnet A , Bourne Y , Marchot P |
| Ref : Neuropharmacology , :108381 , 2020 |
| Abstract : |
| PubMedSearch : Comoletti_2020_Neuropharmacol_184_108381 |
| PubMedID: 33166544 |
| Title : Old and new questions about cholinesterases - Massoulie_2008_Chem.Biol.Interact_175_30 |
| Author(s) : Massoulie J , Perrier N , Noureddine H , Liang D , Bon S |
| Ref : Chemico-Biological Interactions , 175 :30 , 2008 |
| Abstract : |
| PubMedSearch : Massoulie_2008_Chem.Biol.Interact_175_30 |
| PubMedID: 18541228 |
| Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
| Author(s) : Taylor P , Radic Z |
| Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994 |
| Abstract : |
| PubMedSearch : Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281 |
| PubMedID: 8042853 |
| Title : Molecular and cellular biology of cholinesterases - |
| Author(s) : Massoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM |
| Ref : Prog Neurobiol , 41 :31 , 1993 |
| PubMedID: 8321908 |
| Title : Comparison of butyrylcholinesterase and acetylcholinesterase. - |
| Author(s) : Chatonnet A , Lockridge O |
| Ref : Biochemical Journal , 260 :625 , 1989 |
| PubMedID: 2669736 |