Cholinesterase

Relationship

Family: Cholinesterase

Block: C

Parent Family: No family

Comment

Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly

Database

Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : PR00878

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

No Genes Proteins

No fragment of genes

No fragment of genes

Substrates in Cholinesterase family (3)

Inhibitors in Cholinesterase family (7)

References (4)

Title : Old and new questions about cholinesterases - Massoulie_2008_Chem.Biol.Interact_175_30
Author(s) : Massoulie J , Perrier N , Noureddine H , Liang D , Bon S
Ref : Chemico-Biological Interactions , 175 :30 , 2008
PubMedID: 18541228

Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281
Author(s) : Taylor P , Radic Z
Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994
PubMedID: 8042853

Title : Molecular and cellular biology of cholinesterases -
Author(s) : Massoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM
Ref : Prog Neurobiol , 41 :31 , 1993
PubMedID: 8321908

Title : Comparison of butyrylcholinesterase and acetylcholinesterase. -
Author(s) : Chatonnet A , Lockridge O
Ref : Biochemical Journal , 260 :625 , 1989
PubMedID: 2669736