Benzyl-triazol-piperidin-ethoxy-coumarin-Cpdh1
IC50 nM Electric eel AChE 6.03 +/- 0.62; Human AChE 115.0 +/- 8.1; equine serum BChE 3790 +/- 400; hMAO-A 5.2 +/- 1.9; hMAO-B 11.3 +/- 1; Ki hH3R 558 [337; 925]
General
Type : Multitarget, Coumarin, Chromen, Triazol, Piperidine, Histamine-Receptor3-H3-Antagonist, Monoamine-oxidase-inhibitor
Chemical_Nomenclature : 3-(1-Benzyl-1H-1,2,3-triazol-4-yl)-7-(2-(piperidin-1-yl)ethoxy)-2H-chromen-2-one
Canonical SMILES : N5(CCOC1=CC=C2C(=C1)OC(C(=C2)C3=C[N](N=N3)CC4=CC=CC=C4)=O)CCCCC5
InChI : InChI=1S\/C25H26N4O3\/c30-25-22(23-18-29(27-26-23)17-19-7-3-1-4-8-19)15-20-9-10-21(16-24(20)32-25)31-14-13-28-11-5-2-6-12-28\/h1,3-4,7-10,15-16,18H,2,5-6,11-14,17H2
InChIKey : IYLKGBCKFJTMHT-UHFFFAOYSA-N
Other name(s) : Compound 1h
Target
Families : Benzyl-triazol-piperidin-ethoxy-coumarin-Cpdh1 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors - Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| Author(s) : Nadur NF , Ferreira LAP , Franco DP , de Azevedo LL , Caruso L , Honorio TDS , Furtado PS , Simon A , Cabral LM , Werner T , Stark H , Kummerle AE |
| Ref : Pharmaceuticals (Basel) , 18 :1398 , 2025 |
| Abstract : |
| PubMedSearch : Nadur_2025_Pharmaceuticals.(Basel)_18_1398 |
| PubMedID: 41011265 |