Benzylpiperidin-dimethylamino-hydroxyphenyl-pyridazin-one-Cpd7a
EeAChE: IC50 = 0.21 microM; HsAChE: IC50 = 13 nM); RatBChE 25.0 % at 10 microM anti-Abeta (IC50 = 2.92 microM for self-induced Abeta1-42 aggregation; IC50 = 1.28 microM for disaggregation of Abeta1-42 fibrils; IC50 = 3.72 microM for Cu2+-induced Abeta1-42 aggregation; IC50 = 2.16 microM for disaggregation of Cu2+-induced Abeta1-42 fibrils)
General
Type : Pyridazine, Piperidine, anti-Abeta-aggregation, Multitarget, Benzylpiperidine, Derivative of Donepezil
Chemical_Nomenclature : 2-[2-(1-benzylpiperidin-4-yl)ethyl]-6-[5-(dimethylamino)-2-hydroxyphenyl]pyridazin-3(2H)-one
Canonical SMILES : C1(=CC=C(C(=C1)C2=NN(C(C=C2)=O)CCC3CCN(CC3)CC4=CC=CC=C4)O)N(C)C
InChI : InChI=1S\/C26H32N4O2\/c1-28(2)22-8-10-25(31)23(18-22)24-9-11-26(32)30(27-24)17-14-20-12-15-29(16-13-20)19-21-6-4-3-5-7-21\/h3-11,18,20,31H,12-17,19H2,1-2H3
InChIKey : GKFLSUCULBDRMY-UHFFFAOYSA-N
Other name(s) : Compound 7a || 2-[2-(1-Benzyl-4-piperidyl)ethyl]-6-[5-(dimethylamino)-2-hydroxyphenyl]-3(2H)-pyridazinone
Target
Families : Benzylpiperidin-dimethylamino-hydroxyphenyl-pyridazin-one-Cpd7a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease - Shi_2025_Eur.J.Med.Chem_303_118437 |
| Author(s) : Shi Y , Zhang H , Cong S , Zhu X , Liu Y , Li J , Tang K , Xue R , Liu X , Tan Z , Chen J , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 303 :118437 , 2025 |
| Abstract : |
| PubMedSearch : Shi_2025_Eur.J.Med.Chem_303_118437 |
| PubMedID: 41365088 |
| Title : Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease - Shi_2025_Eur.J.Med.Chem_303_118437 |
| Author(s) : Shi Y , Zhang H , Cong S , Zhu X , Liu Y , Li J , Tang K , Xue R , Liu X , Tan Z , Chen J , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 303 :118437 , 2025 |
| Abstract : |
| PubMedSearch : Shi_2025_Eur.J.Med.Chem_303_118437 |
| PubMedID: 41365088 |
| Title : Benzylpiperidine-pyridazin-3(2H)-one derivatives as potential multifunctional agents against Alzheimer's disease - Shi_2025_Eur.J.Med.Chem_303_118437 |
| Author(s) : Shi Y , Zhang H , Cong S , Zhu X , Liu Y , Li J , Tang K , Xue R , Liu X , Tan Z , Chen J , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 303 :118437 , 2025 |
| Abstract : |
| PubMedSearch : Shi_2025_Eur.J.Med.Chem_303_118437 |
| PubMedID: 41365088 |