CHEMBL3233933
IC50 AChE 0.38 +/- 0.07; BChE 1.14 +/- 0.17 microM
General
Type : Derivative of Donepezil, Piperidine, Quinoline, Carboxamide, Benzylpiperidine
Chemical_Nomenclature : 4-amino-N-[(1-benzylpiperidin-4-yl)methyl]-1-methyl-2-oxoquinoline-3-carboxamide
Canonical SMILES : CN1C2=CC=CC=C2C(=C(C1=O)C(=O)NCC3CCN(CC3)CC4=CC=CC=C4)N
InChI : InChI=1S\/C24H28N4O2\/c1-27-20-10-6-5-9-19(20)22(25)21(24(27)30)23(29)26-15-17-11-13-28(14-12-17)16-18-7-3-2-4-8-18\/h2-10,17H,11-16,25H2,1H3,(H,26,29)
InChIKey : OGWLQWKNOZWLAF-UHFFFAOYSA-N
Other name(s) : BDBM50002841 || Compound 5j
MW : 404.5
Formula : C24H28N4O2
CAS_number :
PubChem : 90654547
UniChem : OGWLQWKNOZWLAF-UHFFFAOYSA-N
Target
Families : CHEMBL3233933 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease - Pudlo_2014_Bioorg.Med.Chem_22_2496 |
| Author(s) : Pudlo M , Luzet V , Ismaili L , Tomassoli I , Iutzeler A , Refouvelet B |
| Ref : Bioorganic & Medicinal Chemistry , 22 :2496 , 2014 |
| Abstract : |
| PubMedSearch : Pudlo_2014_Bioorg.Med.Chem_22_2496 |
| PubMedID: 24657052 |