| Title : Discovery of New Highly Potent Histamine H(3) Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors - Malek_2024_ACS.Chem.Neurosci__ |
| Author(s) : Malek R , Salat K , Totoson P , Karcz T , Refouvelet B , Skrzypczak-Wiercioch A , Maj M , Simakov A , Martin H , Siwek A , Szalaj N , Godyn J , Panek D , Wieckowska A , Jozwiak K , Demougeot C , Kiec-Kononowicz K , Chabchoub F , Iriepa I , Marco-Contelles J , Ismaili L |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Malek_2024_ACS.Chem.Neurosci__ |
| PubMedID: 39208251 |
| Title : The Proof-of-Concept of MBA121, a Tacrine-Ferulic Acid Hybrid, for Alzheimer's Disease Therapy - Rodriguez-Ruiz_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Rodriguez-Ruiz ER , Herrero-Labrador R , Fernandez-Fernandez AP , Serrano-Masa J , Martinez-Montero JA , Gonzalez-Nieto D , Hana-Vaish M , Benchekroun M , Ismaili L , Marco-Contelles J , Martinez-Murillo R |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Rodriguez-Ruiz_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37569630 |
| Title : Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer's Disease Treatment - Dakhlaoui_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Dakhlaoui I , Bernard PJ , Pietrzak D , Simakov A , Maj M , Refouvelet B , Beduneau A , Cornu R , Jozwiak K , Chabchoub F , Iriepa I , Martin H , Marco-Contelles J , Ismaili L |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Dakhlaoui_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298693 |
| Title : Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca(2+) Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation - Malek_2022_Molecules_28_ |
| Author(s) : Malek R , Simakov A , Davis A , Maj M , Bernard PJ , Wnorowski A , Martin H , Marco-Contelles J , Chabchoub F , Dallemagne P , Rochais C , Jozwiak K , Ismaili L |
| Ref : Molecules , 28 : , 2022 |
| Abstract : |
| PubMedSearch : Malek_2022_Molecules_28_ |
| PubMedID: 36615267 |
| Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments - Bautista-Aguilera_2021_Chem.Rec_21_162 |
| Author(s) : Bautista-Aguilera O M , Ismaili L , Iriepa I , Diez-Iriepa D , Chabchoub F , Marco-Contelles J , Perez M |
| Ref : Chem Rec , 21 :162 , 2021 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2021_Chem.Rec_21_162 |
| PubMedID: 33169934 |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : Synthesis of new Hantzsch adducts showing Ca(2+) channel blockade capacity, cholinesterase inhibition and antioxidant power - Pachon-Angona_2021_Future.Med.Chem__ |
| Author(s) : Pachon-Angona I , Maj M , Wnorowski A , Martin H , Jozwiak K , Ismaili L |
| Ref : Future Med Chem , : , 2021 |
| Abstract : |
| PubMedSearch : Pachon-Angona_2021_Future.Med.Chem__ |
| PubMedID: 34402661 |
| Title : Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy - Zribi_2020_Molecules_25_ |
| Author(s) : Zribi L , Pachon-Angona I , Bautista-Aguilera OM , Diez-Iriepa D , Marco-Contelles J , Ismaili L , Iriepa I , Chabchoub F |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Zribi_2020_Molecules_25_ |
| PubMedID: 32668671 |
| Title : Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy - Bautista-Aguilera_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Bautista-Aguilera OM , Ismaili L , Chioua M , Andrys R , Schmidt M , Bzonek P , Martinez-Grau MA , Beadle CD , Vetman T , Lopez-Munoz F , Iriepa I , Refouvelet B , Musilek K , Marco-Contelles J |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32486316 |
| Title : Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives - Pachon_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Pachon Angona I , Martin H , Daniel S , Moraleda I , Bonet A , Wnorowski A , Maj M , Jozwiak K , Iriepa I , Refouvelet B , Marco-Contelles J , Ismaili L |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Pachon_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 33081112 |
| Title : Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy - do Carmo Carreiras_2020_Bioorg.Med.Chem.Lett_30_126880 |
| Author(s) : do Carmo Carreiras M , Ismaili L , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :126880 , 2020 |
| Abstract : |
| PubMedSearch : do Carmo Carreiras_2020_Bioorg.Med.Chem.Lett_30_126880 |
| PubMedID: 31864798 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019 |
| Abstract : |
| PubMedSearch : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedID: 30482062 |
| Title : Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy - Malek_2019_Curr.Alzheimer.Res_16_815 |
| Author(s) : Malek R , Refouvelet B , Benchekroun M , Iriepa I , Moraleda I , Andrys R , Musilek K , Marco-Contelles J , Ismaili L |
| Ref : Curr Alzheimer Res , 16 :815 , 2019 |
| Abstract : |
| PubMedSearch : Malek_2019_Curr.Alzheimer.Res_16_815 |
| PubMedID: 31660831 |
| Title : Chromenones as Multineurotargeting Inhibitors of Human Enzymes - Lemke_2019_ACS.Omega_4_22161 |
| Author(s) : Lemke C , Christmann J , Yin J , Alonso JM , Serrano E , Chioua M , Ismaili L , Martinez-Grau MA , Beadle CD , Vetman T , Dato FM , Bartz U , Elsinghorst PW , Pietsch M , Muller CE , Iriepa I , Wille T , Marco-Contelles J , Gutschow M |
| Ref : ACS Omega , 4 :22161 , 2019 |
| Abstract : |
| PubMedSearch : Lemke_2019_ACS.Omega_4_22161 |
| PubMedID: 31891098 |
| Title : Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy - Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| Author(s) : Pachon-Angona I , Refouvelet B , Andrys R , Martin H , Luzet V , Iriepa I , Moraleda I , Diez-Iriepa D , Oset-Gasque MJ , Marco-Contelles J , Musilek K , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :479 , 2019 |
| Abstract : |
| PubMedSearch : Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| PubMedID: 30712420 |
| Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839 |
| Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M |
| Ref : Eur Journal of Medicinal Chemistry , 155 :839 , 2018 |
| Abstract : |
| PubMedSearch : Chioua_2018_Eur.J.Med.Chem_155_839 |
| PubMedID: 29958119 |
| Title : New (benz)imidazolopyridino tacrines as nonhepatotoxic, cholinesterase inhibitors for Alzheimer disease - Boulebd_2017_Future.Med.Chem_9_723 |
| Author(s) : Boulebd H , Ismaili L , Martin H , Bonet A , Chioua M , Marco Contelles J , Belfaitah A |
| Ref : Future Med Chem , 9 :723 , 2017 |
| Abstract : |
| PubMedSearch : Boulebd_2017_Future.Med.Chem_9_723 |
| PubMedID: 28485637 |
| Title : Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy - Dgachi_2017_Future.Med.Chem_9_715 |
| Author(s) : Dgachi Y , Martin H , Bonet A , Chioua M , Iriepa I , Moraleda I , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Future Med Chem , 9 :715 , 2017 |
| Abstract : |
| PubMedSearch : Dgachi_2017_Future.Med.Chem_9_715 |
| PubMedID: 28504912 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease - Ismaili_2017_Prog.Neurobiol_151_4 |
| Author(s) : Ismaili L , Refouvelet B , Benchekroun M , Brogi S , Brindisi M , Gemma S , Campiani G , Filipic S , Agbaba D , Esteban G , Unzeta M , Nikolic K , Butini S , Marco-Contelles J |
| Ref : Prog Neurobiol , 151 :4 , 2017 |
| Abstract : |
| PubMedSearch : Ismaili_2017_Prog.Neurobiol_151_4 |
| PubMedID: 26797191 |
| Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967 |
| Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016 |
| Abstract : |
| PubMedSearch : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedID: 27736061 |
| Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_ |
| Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_Molecules_21_ |
| PubMedID: 27187348 |
| Title : ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy - Marco-Contelles_2016_Front.Neurosci_10_294 |
| Author(s) : Marco-Contelles J , Unzeta M , Bolea I , Esteban G , Ramsay RR , Romero A , Martinez-Murillo R , Carreiras MC , Ismaili L |
| Ref : Front Neurosci , 10 :294 , 2016 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2016_Front.Neurosci_10_294 |
| PubMedID: 27445665 |
| Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576 |
| Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedID: 27918993 |
| Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318 |
| Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J |
| Ref : ChemMedChem , 11 :1318 , 2016 |
| Abstract : |
| PubMedSearch : Dgachi_2016_ChemMedChem_11_1318 |
| PubMedID: 26804623 |
| Title : Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy - Boulebd_2016_Molecules_21_ |
| Author(s) : Boulebd H , Ismaili L , Bartolini M , Bouraiou A , Andrisano V , Martin H , Bonet A , Moraleda I , Iriepa I , Chioua M , Belfaitah A , Marco-Contelles J |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Boulebd_2016_Molecules_21_ |
| PubMedID: 27023499 |
| Title : Donepezil-ferulic acid hybrids as anti-Alzheimer drugs - Benchekroun_2015_Future.Med.Chem_7_15 |
| Author(s) : Benchekroun M , Ismaili L , Pudlo M , Luzet V , Gharbi T , Refouvelet B , Marco-Contelles J |
| Ref : Future Med Chem , 7 :15 , 2015 |
| Abstract : |
| PubMedSearch : Benchekroun_2015_Future.Med.Chem_7_15 |
| PubMedID: 25582330 |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease - Pudlo_2014_Bioorg.Med.Chem_22_2496 |
| Author(s) : Pudlo M , Luzet V , Ismaili L , Tomassoli I , Iutzeler A , Refouvelet B |
| Ref : Bioorganic & Medicinal Chemistry , 22 :2496 , 2014 |
| Abstract : |
| PubMedSearch : Pudlo_2014_Bioorg.Med.Chem_22_2496 |
| PubMedID: 24657052 |
| Title : Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists - Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| Author(s) : Tomassoli I , Ismaili L , Pudlo M , de los Rios C , Soriano E , Colmena I , Gandia L , Rivas L , Samadi A , Marco-Contelles J , Refouvelet B |
| Ref : Eur Journal of Medicinal Chemistry , 46 :1 , 2011 |
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| PubMedSearch : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| PubMedID: 21111515 |