CHEMBL4456083
Ki hCB2R 4500nM IC50 hBCHE 2.0nM
General
Type : Derivative of Tacrine, Alkyl linked bis-ligand, Acridine, Benzimidazole, Carboxamide
Chemical_Nomenclature : 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]benzimidazole-5-carboxamide
Canonical SMILES : CCN(CC)C(=O)C1=CC2=C(C=C1)N(C(=N2)CC3=CC=C(C=C3)OCC)CCCCCCNC4=C5CCCCC5=NC6=CC=CC=C64
InChI : InChI=1S\/C40H49N5O2\/c1-4-44(5-2)40(46)30-21-24-37-36(28-30)43-38(27-29-19-22-31(23-20-29)47-6-3)45(37)26-14-8-7-13-25-41-39-32-15-9-11-17-34(32)42-35-18-12-10-16-33(35)39\/h9,11,15,17,19-24,28H,4-8,10,12-14,16,18,25-27H2,1-3H3,(H,41,42)
InChIKey : UTGZBXOXPAIMOK-UHFFFAOYSA-N
Other name(s) : BDBM50514057
MW : 631.8
Formula : C40H49N5O2
CAS_number :
PubChem : 155524523
UniChem : UTGZBXOXPAIMOK-UHFFFAOYSA-N
Target
References (1)
| Title : Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist\/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model - Spatz_2023_J.Med.Chem__ |
| Author(s) : Spatz P , Steinmuller SAM , Tutov A , Poeta E , Morilleau A , Carles A , Deventer MH , Hofmann J , Stove CP , Monti B , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Spatz_2023_J.Med.Chem__ |
| PubMedID: 37127287 |