CI-1002

anticholinesterase and muscarinic antagonist.

General

Type : Derivative of Tacrine, Muscarinic antagonist, Quinazoline, Azepine

Chemical_Nomenclature : azepino[2,1-b]quinazoline 1,3-dichloro-6,7,8,9,10, 12-hexahydro-, mono-hydrochloride

Canonical SMILES : C1CCC2=NC3=CC(=CC(=C3CN2CC1)Cl)Cl

InChI : InChI=1S\/C13H14Cl2N2\/c14-9-6-11(15)10-8-17-5-3-1-2-4-13(17)16-12(10)7-9\/h6-7H,1-5,8H2

InChIKey : WTPSHLVHJOJDIF-UHFFFAOYSA-N

Other name(s) : PD-142676


MW : 269,17

Formula : C13H14Cl2N2

CAS_number : 149028-28-4

PubChem : 9838284

UniChem : WTPSHLVHJOJDIF-UHFFFAOYSA-N

Target

Families : CI-1002 ligand of proteins in family
ACHE

References (3)

Title : Effects of CI-1002 and CI-1017 on spontaneous synaptic activity and on the nicotinic acetylcholine receptor of Torpedo electric organ - Ros_2000_Eur.J.Pharmacol_390_7
Author(s) : Ros E , Aleu J , Marsal J , Solsona C
Ref : European Journal of Pharmacology , 390 :7 , 2000
Abstract :
PubMedSearch : Ros_2000_Eur.J.Pharmacol_390_7
PubMedID: 10708701

Title : Trace quantitation of the novel cholinesterase inhibitor in human plasma by capillary gas chromatography\/ion trap mass spectrometry - Hoffman_1995_J.Pharm.Biomed.Anal_13_979
Author(s) : Hoffman KL , Rossi DT , Wright DS
Ref : J Pharm Biomed Anal , 13 :979 , 1995
Abstract :
PubMedSearch : Hoffman_1995_J.Pharm.Biomed.Anal_13_979
PubMedID: 8580157

Title : PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist - Emmerling_1994_Mol.Neurobiol_9_93
Author(s) : Emmerling MR , Gregor VE , Schwarz RD , Scholten JD , Callahan MJ , Lee C , Moore CJ , Raby C , Lipinski WJ , Davis RE
Ref : Molecular Neurobiology , 9 :93 , 1994
Abstract :
PubMedSearch : Emmerling_1994_Mol.Neurobiol_9_93
PubMedID: 7888109