Canadine
Derivative of Berberine isolated from Corydalis cava (Papaveraceae). IC50 values of for hAChE 0.70 +/- 0.07 muM hBChE (IC50 values > 100 muM)
General
Chemical_Nomenclature : 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene
Canonical SMILES : COC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC
InChI : InChI=1S\/C20H21NO4\/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2\/h3-4,8-9,16H,5-7,10-11H2,1-2H3
InChIKey : VZTUIEROBZXUFA-UHFFFAOYSA-N
Other name(s) : (+)-canadine || Tetrahydroberberine || Xanthopuccine || Canadin || CHEMBL275097 || CHEBI:22998 || (d,l)-Tetrahydroberberine
MW : 339.39
Formula : C20H21NO4
CAS_number : 522-97-4
PubChem : 34458
UniChem : VZTUIEROBZXUFA-UHFFFAOYSA-N
Target
Families : Canadine ligand of proteins in family
ACHE
BCHE
Cholinesterase
References (1)
| Title : In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier - Chlebek_2019_Molecules_24_ |
| Author(s) : Chlebek J , Korabecny J , Dolezal R , Stepankova S , Perez DI , Hostalkova A , Opletal L , Cahlikova L , Macakova K , Kucera T , Hrabinova M , Jun D |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Chlebek_2019_Molecules_24_ |
| PubMedID: 30959739 |