Chloro-dichlorobenzyl-methoxyacridin-amine-Cpd20
IC50 (microM) hAChE 0.614 +/- 0.063, hBChE 0.448 +/- 0.051 hMAO-A 3.73 +/- 0.02 hMAO-B 1.55 +/- 0.05
General
Type : Acridine, Derivative of Tacrine, Organochlorine, Monoamine-oxidase-inhibitor, Multitarget
Chemical_Nomenclature : 6-Chloro-N-(3,4-dichlorobenzyl)-2-methoxyacridin-9-amine
Canonical SMILES : C1=C(C=C2C(=C1)C(=C3C(=N2)C=CC(=C3)OC)NCC4=CC(=C(C=C4)Cl)Cl)Cl
InChI : InChI=1S\/C21H15Cl3N2O\/c1-27-14-4-7-19-16(10-14)21(15-5-3-13(22)9-20(15)26-19)25-11-12-2-6-17(23)18(24)8-12\/h2-10H,11H2,1H3,(H,25,26)
InChIKey : DGYLYFWVHVGKQN-UHFFFAOYSA-N
Other name(s) :
Target
Families : Chloro-dichlorobenzyl-methoxyacridin-amine-Cpd20 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Assessing the Multitarget Therapeutic Potential of Novel 9-Aminoacridine Derivatives for Alzheimer's Disease - Francesconi_2026_ACS.Chem.Neurosci__ |
| Author(s) : Francesconi V , Carbone A , La Spada G , Odino D , Canale C , Relini A , Pricl S , Catto M , Tonelli M |
| Ref : ACS Chem Neurosci , : , 2026 |
| Abstract : |
| PubMedSearch : Francesconi_2026_ACS.Chem.Neurosci__ |
| PubMedID: 41508864 |