Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4d
dual inhibitor of FAAH (not aB-hydrolase) and sEH. Human FAAH IC50 (nM) 19.6; Human sEH IC50 (nM) 1.7; Mouse sEH IC50 (nM) 17.2; Rat sEH IC50 (nM) 2.0
General
Type : Piperidine, Sulfur Compound, Sulfonamide, Carboxamide, Multitarget
Chemical_Nomenclature : 1-(2-chlorophenyl)sulfonyl-N-quinolin-6-ylpiperidine-4-carboxamide
Canonical SMILES : N2([S](C1=CC=CC=C1Cl)(=O)=O)CCC(CC2)C(=O)NC3=CC=C(C=C3)C4=CC=CC5=C4C=CC=N5
InChI : InChI=1S\/C27H24ClN3O3S\/c28-24-7-1-2-9-26(24)35(33,34)31-17-14-20(15-18-31)27(32)30-21-12-10-19(11-13-21)22-5-3-8-25-23(22)6-4-16-29-25\/h1-13,16,20H,14-15,17-18H2,(H,30,32)
InChIKey : BMZKVEZKVRYIHX-UHFFFAOYSA-N
Other name(s) : Compound 4d
Target
Families : Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4d ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations - Angelia_2024_Heliyon_10_e32262 |
| Author(s) : Angelia J , Duong L , Yun F , Mesic A , Yuan C , Carr D , Gunari S , Hudson PK , Morisseau C , Hammock BD , Kandasamy R , Pecic S |
| Ref : Heliyon , 10 :e32262 , 2024 |
| Abstract : |
| PubMedSearch : Angelia_2024_Heliyon_10_e32262 |
| PubMedID: 38912512 |