Chlorophenyl-sulfonyl-quinoxalin-phenyl-piperidine-carboxamide-4m
compound that dually inhibits SEH and FAAH (not an alpha/beta hydrolase) || dual inhibitor of FAAH (not aB-hydrolase) and sEH: IC50 (nM) 2.9 (FAAH) 0.7 (sEH)
General
Type : Piperidine, Sulfur Compound, Sulfonamide, Carboxamide, Multitarget, Organochlorine
Chemical_Nomenclature : 1-((2-chlorophenyl)sulfonyl)-N-(4-(quinoxalin-2-yl)phenyl)piperidine-4-carboxamide
Canonical SMILES : N(C(C1CCN(CC1)[S](=O)(=O)C2=C(C=CC=C2)Cl)=O)C3=CC=C(C=C3)C4=NC5=C(N=C4)C=CC=C5
InChI : InChI=1S\/C26H23ClN4O3S\/c27-21-5-1-4-8-25(21)35(33,34)31-15-13-19(14-16-31)26(32)29-20-11-9-18(10-12-20)24-17-28-22-6-2-3-7-23(22)30-24\/h1-12,17,19H,13-16H2,(H,29,32)
InChIKey : UBDAPGRKRNHWFH-UHFFFAOYSA-N
Other name(s) : Compound 4m
Target
Families : Chlorophenyl-sulfonyl-quinoxalin-phenyl-piperidine-carboxamide-4m ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Polynitrogen-containing compounds as multi-target sEH\/FAAH inhibitors: Structure-activity relationship and pharmacological studies - Tsang_2025_Bioorg.Med.Chem_133_118495 |
| Author(s) : Tsang A , Yuan C , Berumen M , Duong L , Gomez K , Seely S , Salgado A , Rai A , Vistosa J , Munoz EM , Ortega ME , Morisseau C , Hammock BD , Zuckerman JE , Yount J , Piercey DG , Kandasamy R , Pecic S |
| Ref : Bioorganic & Medicinal Chemistry , 133 :118495 , 2025 |
| Abstract : |
| PubMedSearch : Tsang_2025_Bioorg.Med.Chem_133_118495 |
| PubMedID: 41289658 |