Cinnamic-acid-N-benzyl-pyridinium-Cpd7b
AChE IC50 0.89 microM; BChE IC50 = 0.11 microM. Competitive inhibitor of AChE (Ki = 0.49 microM)
General
Type : Hydroxycinnamic-ester, Pyridine, Pyridinium, Derivative of Donepezil, Cinnamate
Chemical_Nomenclature : 3-[(2-benzoylethylcarbonylamino)methyl]-1-(2-fluorophenyl)pyridin-1-ium
Canonical SMILES : C1=CC=C(C=C1)C(CCC(NCC2=C[N+](=CC=C2)C3=C(C=CC=C3)F)=O)=O
InChI : InChI=1S\/C22H19FN2O2\/c23-19-10-4-5-11-20(19)25-14-6-7-17(16-25)15-24-22(27)13-12-21(26)18-8-2-1-3-9-18\/h1-11,14,16H,12-13,15H2\/p+1
InChIKey : TYMKVDZDSCAVRN-UHFFFAOYSA-O
Other name(s) : Compound 7b || 1-(o-Fluorophenyl)-3-[(4-oxo-4-phenylpropionylamino)methyl]-1-pyridinium
Target
Families : Cinnamic-acid-N-benzyl-pyridinium-Cpd7b ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Novel cinnamic acid-based N-benzyl pyridinium analogs: potent dual cholinesterase inhibitors with neuroprotective properties for Alzheimer's disease - Esmkhani_2026_RSC.Adv_16_9293 |
| Author(s) : Esmkhani M , Mahdavi M , Javanshir S , Iraji A |
| Ref : RSC Adv , 16 :9293 , 2026 |
| Abstract : |
| PubMedSearch : Esmkhani_2026_RSC.Adv_16_9293 |
| PubMedID: 41704453 |