Compound-47
In the screen for inhibitors of ABH2 Compounds 47 and 60 were the most potent ABHD3 inhibitors that remained selective over the other measured
General
Type : Carbamate
Chemical_Nomenclature :
Canonical SMILES : C[C@H](NC(=O)C(F)(F)C(=O)CCc1ccccc1)c1ccccc1
InChI : InChI=1S\/C19H19F2NO2\/c1-14(16-10-6-3-7-11-16)22-18(24)19(20,21)17(23)13-12-15-8-4-2-5-9-15\/h2-11,14H,12-13H2,1H3,(H,22,24)\/t14-\/m0\/s1
InChIKey : SCLSXPKHZUYHOA-AWEZNQCLSA-N
Other name(s) :
Target
Families : Compound-47 ligand of proteins in family
abh_upf0017
Protein :
human-ABHD3
References (2)
| Title : alpha\/beta-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases - Bononi_2021_J.Med.Chem_64_9759 |
| Author(s) : Bononi G , Tuccinardi T , Rizzolio F , Granchi C |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_J.Med.Chem_64_9759 |
| PubMedID: 34213320 |
| Gene_locus related to this paper: human-ABHD3 |
| Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M |
| Ref : ACS Chemical Biology , 14 :2295 , 2019 |
| Abstract : |
| PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedID: 31525885 |
| Gene_locus related to this paper: human-ABHD2 , human-ABHD3 |