| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Title : Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives - Bononi_2022_J.Med.Chem__ |
| Author(s) : Bononi G , Di Stefano M , Poli G , Ortore G , Meier P , Masetto F , Caligiuri I , Rizzolio F , Macchia M , Chicca A , Avan A , Giovannetti E , Vagaggini C , Brai A , Dreassi E , Valoti M , Minutolo F , Granchi C , Gertsch J , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : |
| PubMedSearch : Bononi_2022_J.Med.Chem__ |
| PubMedID: 35522977 |
| Title : Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold - Bononi_2021_Eur.J.Med.Chem_223_113679 |
| Author(s) : Bononi G , Tonarini G , Poli G , Barravecchia I , Caligiuri I , Macchia M , Rizzolio F , Demontis GC , Minutolo F , Granchi C , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 223 :113679 , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| PubMedID: 34218085 |
| Title : alpha\/beta-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases - Bononi_2021_J.Med.Chem_64_9759 |
| Author(s) : Bononi G , Tuccinardi T , Rizzolio F , Granchi C |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_J.Med.Chem_64_9759 |
| PubMedID: 34213320 |
| Gene_locus related to this paper: human-ABHD3 |
| Title : An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present) - Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| Author(s) : Bononi G , Poli G , Rizzolio F , Tuccinardi T , Macchia M , Minutolo F , Granchi C |
| Ref : Expert Opin Ther Pat , 31 :153 , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| PubMedID: 33085920 |
| Title : Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Granchi_2020_Eur.J.Med.Chem_209_112857 |
| Author(s) : Granchi C , Bononi G , Ferrisi R , Gori E , Mantini G , Glasmacher S , Poli G , Palazzolo S , Caligiuri I , Rizzolio F , Canzonieri V , Perin T , Gertsch J , Sodi A , Giovannetti E , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Eur Journal of Medicinal Chemistry , 209 :112857 , 2020 |
| Abstract : |
| PubMedSearch : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedID: 33045662 |
| Gene_locus related to this paper: human-MGLL |
| Title : Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor - Granchi_2019_J.Med.Chem_62_1932 |
| Author(s) : Granchi C , Lapillo M , Glasmacher S , Bononi G , Licari C , Poli G , El Boustani M , Caligiuri I , Rizzolio F , Gertsch J , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Journal of Medicinal Chemistry , 62 :1932 , 2019 |
| Abstract : |
| PubMedSearch : Granchi_2019_J.Med.Chem_62_1932 |
| PubMedID: 30715876 |
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |