1. Home
  2. Gene Locus
  3. human-ABHD3

human-ABHD3

Homo sapiens (Human) Phospholipase ABHD3

Comment

Lipase that selectively cleaves medium-chain and oxidatively truncated phospholipids Long et al. 2011

Relationship

Family : abh_upf0017

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Database

Sequence

Peptide

GVGSGAASAL ARSRPLASRL SSRRRTRAPR SGAMQRLAMD LRMLSRELSL YLEHQVRVGF FGSGVGLSLI LGFSVAYAFY YLSSIAKKPQ LVTGGESFSR FLQDHCPVVT ETYYPTVWCW EGRGQTLLRP FITSKPPVQY RNELIKTADG GQISLDWFDN DNSTCYMDAS TRPTILLLPG LTGTSKESYI LHMIHLSEEL GYRCVVFNNR GVAGENLLTP RTYCCANTED LETVIHHVHS LYPSAPFLAA GVSMGGMLLL NYLGKIGSKT PLMAAATFSV GWNTFACSES LEKPLNWLLF NYYLTTCLQS SVNKHRHMFV KQVDMDHVMK AKSIREFDKR FTSVMFGYQT IDDYYTDASP SPRLKSVGIP VLCLNSVDDV FSPSHAIPIE TAKQNPNVAL VLTSYGGHIG FLEGIWPRQS TYMDRVFKQF VQAMVEHGHE LS

References (9)

Title : alpha\/beta-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases - Bononi_2021_J.Med.Chem_64_9759
Author(s) : Bononi G , Tuccinardi T , Rizzolio F , Granchi C
Ref : Journal of Medicinal Chemistry , : , 2021
Abstract :
PubMedSearch : Bononi_2021_J.Med.Chem_64_9759
PubMedID: 34213320
Gene_locus related to this paper: human-ABHD3

Title : A large-scale genome-lipid association map guides lipid identification - Linke_2020_Nat.Metab_2_1149
Author(s) : Linke V , Overmyer KA , Miller IJ , Brademan DR , Hutchins PD , Trujillo EA , Reddy TR , Russell JD , Cushing EM , Schueler KL , Stapleton DS , Rabaglia ME , Keller MP , Gatti DM , Keele GR , Pham D , Broman KW , Churchill GA , Attie AD , Coon JJ
Ref : Nat Metab , 2 :1149 , 2020
Abstract :
PubMedSearch : Linke_2020_Nat.Metab_2_1149
PubMedID: 32958938
Gene_locus related to this paper: human-ABHD1 , human-ABHD3

Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295
Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M
Ref : ACS Chemical Biology , 14 :2295 , 2019
Abstract :
PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295
PubMedID: 31525885
Gene_locus related to this paper: human-ABHD2 , human-ABHD3

Title : Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors - Tan_2017_Nat.Commun_8_1760
Author(s) : Tan J , Cognetta AB, 3rd , Diaz DB , Lum KM , Adachi S , Kundu S , Cravatt BF , Yudin AK
Ref : Nat Commun , 8 :1760 , 2017
Abstract :
PubMedSearch : Tan_2017_Nat.Commun_8_1760
PubMedID: 29170371
Gene_locus related to this paper: human-ABHD3 , mouse-abhd3

Title : In vivo metabolite profiling as a means to identify uncharacterized lipase function: Recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family - Thomas_2014_Biochim.Biophys.Acta_1841_1097
Author(s) : Thomas G , Brown AL , Brown JM
Ref : Biochimica & Biophysica Acta , 1841 :1097 , 2014
Abstract :
PubMedSearch : Thomas_2014_Biochim.Biophys.Acta_1841_1097
PubMedID: 24423940
Gene_locus related to this paper: human-ABHD3 , human-ABHD6 , human-ABHD12

Title : Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations - Demirkan_2012_PLoS.Genet_8_e1002490
Author(s) : Demirkan A , van Duijn CM , Ugocsai P , Isaacs A , Pramstaller PP , Liebisch G , Wilson JF , Johansson , Rudan I , Aulchenko YS , Kirichenko AV , Janssens AC , Jansen RC , Gnewuch C , Domingues FS , Pattaro C , Wild SH , Jonasson I , Polasek O , Zorkoltseva IV , Hofman A , Karssen LC , Struchalin M , Floyd J , Igl W , Biloglav Z , Broer L , Pfeufer A , Pichler I , Campbell S , Zaboli G , Kolcic I , Rivadeneira F , Huffman J , Hastie ND , Uitterlinden A , Franke L , Franklin CS , Vitart V , Nelson CP , Preuss M , Bis JC , O'Donnell CJ , Franceschini N , Witteman JC , Axenovich T , Oostra BA , Meitinger T , Hicks AA , Hayward C , Wright AF , Gyllensten U , Campbell H , Schmitz G
Ref : PLoS Genet , 8 :e1002490 , 2012
Abstract :
PubMedSearch : Demirkan_2012_PLoS.Genet_8_e1002490
PubMedID: 22359512
Gene_locus related to this paper: human-ABHD3

Title : Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids - Long_2011_Nat.Chem.Biol_7_763
Author(s) : Long JZ , Cisar JS , Milliken D , Niessen S , Wang C , Trauger SA , Siuzdak G , Cravatt BF
Ref : Nat Chemical Biology , 7 :763 , 2011
Abstract :
PubMedSearch : Long_2011_Nat.Chem.Biol_7_763
PubMedID: 21926997
Gene_locus related to this paper: human-ABHD3 , mouse-abhd3

Title : Large-scale concatenation cDNA sequencing - Yu_1997_Genome.Res_7_353
Author(s) : Yu W , Andersson B , Worley KC , Muzny DM , Ding Y , Liu W , Ricafrente JY , Wentland MA , Lennon G , Gibbs RA
Ref : Genome Res , 7 :353 , 1997
Abstract :
PubMedSearch : Yu_1997_Genome.Res_7_353
PubMedID: 9110174
Gene_locus related to this paper: human-ABHD3

Title : A double adaptor method for improved shotgun library construction - Andersson_1996_Anal.Biochem_236_107
Author(s) : Andersson B , Wentland MA , Ricafrente JY , Liu W , Gibbs RA
Ref : Analytical Biochemistry , 236 :107 , 1996
Abstract :
PubMedSearch : Andersson_1996_Anal.Biochem_236_107
PubMedID: 8619474
Gene_locus related to this paper: human-ABHD3