Compound-9368
IC50 around 90 nM. human-LIPE. hDAGL-alpha LEI103: IC50=3.8+/-0.4 microM
General
Type : Oxadiazol
Chemical_Nomenclature : N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3-yl)-2-methylphenyl]-2-phenylacetamide
Canonical SMILES : CC1=C(C=CC(=C1)N2C(=O)OC(=N2)OC)NC(=O)CC3=CC=CC=C3
InChI : InChI=1S\/C18H17N3O4\/c1-12-10-14(21-18(23)25-17(20-21)24-2)8-9-15(12)19-16(22)11-13-6-4-3-5-7-13\/h3-10H,11H2,1-2H3,(H,19,22)
InChIKey : TYRSXXKVBQHZIC-UHFFFAOYSA-N
Other name(s) : Compound 9368 || LEI103
MW : 339.3
Formula : C18H17N3O4
CAS_number :
PubChem : 57325525
UniChem : TYRSXXKVBQHZIC-UHFFFAOYSA-N
Target
Families : Compound-9368 ligand of proteins in family
Hormone-sensitive_lipase_like
Lipase_3
Protein :
human-LIPE
human-DAGLA
References (3)
| Title : Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification - van Rooden_2018_Nat.Protoc_13_752 |
| Author(s) : van Rooden EJ , Florea BI , Deng H , Baggelaar MP , van Esbroeck ACM , Zhou J , Overkleeft HS , van der Stelt M |
| Ref : Nat Protoc , 13 :752 , 2018 |
| Abstract : |
| PubMedSearch : van Rooden_2018_Nat.Protoc_13_752 |
| PubMedID: 29565900 |
| Title : The molecular mechanism of human hormone-sensitive lipase inhibition by substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones - Ben Ali_2012_Biochimie_94_137 |
| Author(s) : Ben Ali Y , Verger R , Carriere F , Petry S , Muller G , Abousalham A |
| Ref : Biochimie , 94 :137 , 2012 |
| Abstract : |
| PubMedSearch : Ben Ali_2012_Biochimie_94_137 |
| PubMedID: 22008857 |
| Gene_locus related to this paper: human-LIPE |
| Title : Use of an inhibitor to identify members of the hormone-sensitive lipase family - Ben Ali_2006_Biochemistry_45_14183 |
| Author(s) : Ben Ali Y , Chahinian H , Petry S , Muller G , Lebrun R , Verger R , Carriere F , Mandrich L , Rossi M , Manco G , Sarda L , Abousalham A |
| Ref : Biochemistry , 45 :14183 , 2006 |
| Abstract : |
| PubMedSearch : Ben Ali_2006_Biochemistry_45_14183 |
| PubMedID: 17115713 |
| Gene_locus related to this paper: human-LIPE |