Cyclohexylaminopropyl-Kenpaullone-carboxamide-Cpd18o
Kenpaullone derivative. 18o is a dual inhibitor of GSK-3beta (IC50 5.7 microM) and AChE (IC50 1.7 microM)
General
Type : GSK-3 kinase inhibitor, Multitarget, Indole, Carboxamide, Azepane
Chemical_Nomenclature : N-(3-(Cyclohexylamino)propyl)-6-oxo-5,6,7,12-tetrahydrobenzo[2,3]azepino[4,5-b]indole-9-carboxamide
Canonical SMILES : C12=CC=CC=C1NC(CC3=C2[N]C4=C3C=C(C=C4)C(NCCCNC5CCCCC5)=O)=O
InChI : InChI=1S\/C26H30N4O2\/c31-24-16-21-20-15-17(26(32)28-14-6-13-27-18-7-2-1-3-8-18)11-12-23(20)30-25(21)19-9-4-5-10-22(19)29-24\/h4-5,9-12,15,18,27,30H,1-3,6-8,13-14,16H2,(H,28,32)(H,29,31)
InChIKey : PURWVZJZARMVSU-UHFFFAOYSA-N
Other name(s) : Compound 18o
Target
Families : Cyclohexylaminopropyl-Kenpaullone-carboxamide-Cpd18o ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3beta - Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| Author(s) : Raghuvanshi R , Wakudkar SC , Manda S , Bharate SB |
| Ref : Bioorg Chem , 167 :109232 , 2025 |
| Abstract : |
| PubMedSearch : Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| PubMedID: 41240623 |
| Title : Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3beta - Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| Author(s) : Raghuvanshi R , Wakudkar SC , Manda S , Bharate SB |
| Ref : Bioorg Chem , 167 :109232 , 2025 |
| Abstract : |
| PubMedSearch : Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| PubMedID: 41240623 |
| Title : Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3beta - Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| Author(s) : Raghuvanshi R , Wakudkar SC , Manda S , Bharate SB |
| Ref : Bioorg Chem , 167 :109232 , 2025 |
| Abstract : |
| PubMedSearch : Raghuvanshi_2025_Bioorg.Chem_167_109232 |
| PubMedID: 41240623 |