DH379
General
Type : Piperidine, Triazol, Urea derivative, Fluorescent Probe, BODIPY-derivative, Boranuidatricyclo, Boron compound
Chemical_Nomenclature :
Canonical SMILES : C1=CC(=CC=C1)C[C@@H]2N(C[C@@H](CC2)OCC3=C[N](N=N3)CCCOC7=CC=C(C4=CC=C6[N]4[B-]([N+]5=C(C(=C(C5=C6)C)CCC(O)=O)C)(F)F)C=C7)C(=O)[N]8N=CC(=N8)C(C9=CC=C(C=C9)F)(O)C\%10=CC=C(C=C\%10)F || C1=CC(=CC=C1)C[C@@H]2N(C[C@@H](CC2)OCC3=C[N](N=N3)CCCOC7=CC=C(C4=CC=C6[N]4[B-]([N ]5=C(C(=C(C5=C6)C)CCC(O)=O)C)(F)F)C=C7)C(=O)[N]8N=CC(=N8)C(C9=CC=C(C=C9)F)(O)C=CC=C(C=C)F
InChI : 1S\/C54H52BF4N9O6\/c1-35-48(24-26-52(69)70)36(2)66-50(35)30-45-20-25-49(67(45)55(66,58)59)38-9-21-46(22-10-38)73-28-6-27-64-32-43(61-63-64)34-74-47-23-19-44(29-37-7-4-3-5-8-37)65(33-47)53(71)68-60-31-51(62-68)54(72,39-11-15-41(56)16-12-39)40-13-17-42(57)18-14-40\/h3-5,7-18,20-22,25,30-32,44,47,72H,6,19,23-24,26-29,33-34H2,1-2H3,(H,69,70)\/t44-,47-\/m1\/s1
InChIKey : MMYCIPQZMGCCPI-GVBTYHKLSA-N
Other name(s) :
MW : 1009.41
Formula : C54H52BF4N9O6
CAS_number :
PubChem : 129188688
UniChem : MMYCIPQZMGCCPI-GVBTYHKLSA-N
Target
Families : DH379 ligand of proteins in family
Lipase_3
Protein :
human-DAGLA
human-DAGLB
References (5)
| Title : Covalent fluorescent probes for 2-arachidonoylglycerol metabolic pathways - Puijmbroeck_2026_Br.J.Pharmacol__ |
| Author(s) : Puijmbroeck NDF , van der Stelt M |
| Ref : British Journal of Pharmacology , : , 2026 |
| Abstract : |
| PubMedSearch : Puijmbroeck_2026_Br.J.Pharmacol__ |
| PubMedID: 41549057 |
| Title : Covalent fluorescent probes for 2-arachidonoylglycerol metabolic pathways - Puijmbroeck_2026_Br.J.Pharmacol__ |
| Author(s) : Puijmbroeck NDF , van der Stelt M |
| Ref : British Journal of Pharmacology , : , 2026 |
| Abstract : |
| PubMedSearch : Puijmbroeck_2026_Br.J.Pharmacol__ |
| PubMedID: 41549057 |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |