Diarylurea-hydroxyamidine-3q
AChE IC50 1.72 +/- 0.15 microM, BChE, IC50 6.69 +/- 0.28 micoM
General
Type : Multitarget, Urea derivative, Oxime, anti-Abeta-aggregation, anti-tau-aggregation
Chemical_Nomenclature : (Z)-3-(3-(3-fluorophenyl)ureido)-N-hydroxybenzimidamide
Canonical SMILES : C1(=CC=CC(=C1)NC(NC2=CC=CC(=C2)F)=O)C(=NO)N
InChI : InChI=1S\/C14H13FN4O2\/c15-10-4-2-6-12(8-10)18-14(20)17-11-5-1-3-9(7-11)13(16)19-21\/h1-8,21H,(H2,16,19)(H2,17,18,20)
InChIKey : MREHWTUNQLQCEL-UHFFFAOYSA-N
Other name(s) :
Target
Families : Diarylurea-hydroxyamidine-3q ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of novel substituted (Z)-N'-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease - Shankar_2024_Eur.J.Med.Chem_280_116959 |
| Author(s) : Shankar G , Praveen Kumar C , Yadav M , Ghosh A , Panda SR , Banerjee A , Tiwari A , Rai S , Kumar S , Garg P , Naidu VGM , Kulkarni O , Modi G |
| Ref : Eur Journal of Medicinal Chemistry , 280 :116959 , 2024 |
| Abstract : |
| PubMedSearch : Shankar_2024_Eur.J.Med.Chem_280_116959 |
| PubMedID: 39461036 |