anti-tau-aggregation
General
Accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders. Not an alpha\/beta hydrolase target but can be used as a building block for larger inhibitors of enzymes of the family designed as multitarget compounds
| Inhibitor | Main targeted enzyme familyes | Type | Structure |
|---|---|---|---|
| Ass-IN-10 | BCHE | Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl |
|
| Methylene-blue | ACHE BCHE | Dye Drug Phenothiazine anti-tau-aggregation Multitarget Sulfur Compound |
|