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anti-tau-aggregation

General

Accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders. Not an alpha/beta hydrolase target but can be used as a building block for larger inhibitors of enzymes of the family designed as multitarget compounds
Inhibitor Main targeted enzyme families Type Structure
Diarylurea-hydroxyamidine-3q BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Ass-IN-10 BCHE Multitarget BACE1-inhibitor anti-Abeta-aggregation anti-tau-aggregation Alkyl linked bis-ligand tert-Butyl
Methylene-blue ACHE BCHE Dye Drug Phenothiazine anti-tau-aggregation Multitarget Sulfur Compound Antioxidant