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Oxime

General

Componds like RR'C=NOH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. Oxime compounds can reactivate OP inhibited cholinesterases by attaching to phosphorus, forming an oxime-phosphonate, which then splits away from the acetylcholinesterase molecule
Inhibitor Main targeted enzyme families Type Structure
Fluoro-dihydroxy-biphenyl-tetradecan-one-oxime-Cpd14a Monoglyceridelipase_lysophospholip Tetradecanoate Myristate Biphenyl Oxime
Diarylurea-hydroxyamidine-3q BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
7P1P-4IX ACHE Oxime Triazol
N-alkyl-quinuclidine-cpd14 BCHE ACHE Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
DEP-2PAM ACHE Organophosphate Phosphonylated oxime
DEP-4PAM ACHE Organophosphate Phosphonylated oxime
EMP-TMB4 ACHE Organophosphate Phosphonylated oxime Organochlorine
EMP-Toxogonin ACHE Organophosphate Phosphonylated oxime Organochlorine
Fluoro-dihydroxy-biphenyl-tetradecan-one-oxime-Cpd14a Monoglyceridelipase_lysophospholip Tetradecanoate Myristate Biphenyl Oxime
Diarylurea-hydroxyamidine-3q BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
7P1P-4IX ACHE Oxime Triazol
N-alkyl-quinuclidine-cpd14 BCHE ACHE Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
DEP-2PAM ACHE Organophosphate Phosphonylated oxime
DEP-4PAM ACHE Organophosphate Phosphonylated oxime
EMP-TMB4 ACHE Organophosphate Phosphonylated oxime Organochlorine
EMP-Toxogonin ACHE Organophosphate Phosphonylated oxime Organochlorine
Fluoro-dihydroxy-biphenyl-tetradecan-one-oxime-Cpd14a Monoglyceridelipase_lysophospholip Tetradecanoate Myristate Biphenyl Oxime
Diarylurea-hydroxyamidine-3q BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
Diarylurea-hydroxyamidine-6e BCHE Multitarget Urea derivative Oxime anti-Abeta-aggregation anti-tau-aggregation
7P1P-4IX ACHE Oxime Triazol
N-alkyl-quinuclidine-cpd14 BCHE ACHE Oxime Quinuclidine Bisquaternary Alkyl linked bis-ligand
7-MEOTA-4-pyridinealdoxime ACHE Derivative of Tacrine Acridine Pyridine Pyridine-aldoxime
DEP-2PAM ACHE Organophosphate Phosphonylated oxime
DEP-4PAM ACHE Organophosphate Phosphonylated oxime
EMP-TMB4 ACHE Organophosphate Phosphonylated oxime Organochlorine
EMP-Toxogonin ACHE Organophosphate Phosphonylated oxime Organochlorine