Diarylurea-hydroxyamidine-6e
AChE IC50 0.91 +/- 0.016 microM, BChE, IC50 1.19 +/- 0.026 microM
General
Type : Multitarget, Urea derivative, Oxime, anti-Abeta-aggregation, anti-tau-aggregation
Chemical_Nomenclature : (Z)-N-hydroxy-3-(3-(2-(5-methoxy-1H-indol-3-yl)ethyl)ureido)benzimidamide
Canonical SMILES : C1(=CC=CC(=C1)NC(NCCC2CNC3=C2C=C(C=C3)OC)=O)C(=NO)N
InChI : InChI=1S\/C19H23N5O3\/c1-27-15-5-6-17-16(10-15)13(11-22-17)7-8-21-19(25)23-14-4-2-3-12(9-14)18(20)24-26\/h2-6,9-10,13,22,26H,7-8,11H2,1H3,(H2,20,24)(H2,21,23,25)
InChIKey : QHYDGDJYTRZSCT-UHFFFAOYSA-N
Other name(s) :
Target
Families : Diarylurea-hydroxyamidine-6e ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of novel substituted (Z)-N'-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease - Shankar_2024_Eur.J.Med.Chem_280_116959 |
| Author(s) : Shankar G , Praveen Kumar C , Yadav M , Ghosh A , Panda SR , Banerjee A , Tiwari A , Rai S , Kumar S , Garg P , Naidu VGM , Kulkarni O , Modi G |
| Ref : Eur Journal of Medicinal Chemistry , 280 :116959 , 2024 |
| Abstract : |
| PubMedSearch : Shankar_2024_Eur.J.Med.Chem_280_116959 |
| PubMedID: 39461036 |