Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49
eeAChE 0.072 +/- 0.002 microM; eqBChE 9.81 +/- 0.07 microM; MAO-A 14.52 +/- 0.12 microM; MAO-B 0.024 +/- 0.001 microM; BACE-1 2.42 +/- 0.26
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Carboxamide, Benzothiazol, Dioxothiazolidine, Sulfur Compound
Chemical_Nomenclature : (E)-N-(2-(((2,4-dioxothiazolidin-3-yl)methyl)amino)benzo[d]thiazol-5-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide
Canonical SMILES : C1=C(C=C2C(=C1)SC(=N2)NCN3C(SCC3=O)=O)NC(C=CC4=CC(=C(C=C4)O)OC)=O
InChI : InChI=1S\/C21H18N4O5S2\/c1-30-16-8-12(2-5-15(16)26)3-7-18(27)23-13-4-6-17-14(9-13)24-20(32-17)22-11-25-19(28)10-31-21(25)29\/h2-9,26H,10-11H2,1H3,(H,22,24)(H,23,27)
InChIKey : JWIPYSWKJTZWIL-UHFFFAOYSA-N
Other name(s) : Compound 49
Target
Families : Dioxothiazolidin-benzothiazol-methoxyphenyl-acrylamide-Cpd49 ligand of proteins in family
ACHE
References (1)
| Title : Promising thiazolidinedione-thiazole based multi-target and neuroprotective hybrids for Alzheimer's disease: Design, synthesis, in-vitro, in-vivo and in-silico studies - Hussain_2025_Eur.J.Med.Chem_287_117327 |
| Author(s) : Hussain F , Tahir A , Rehman HM , Wu Y , Shah M , Rashid U |
| Ref : Eur Journal of Medicinal Chemistry , 287 :117327 , 2025 |
| Abstract : |
| PubMedSearch : Hussain_2025_Eur.J.Med.Chem_287_117327 |
| PubMedID: 39914143 |