Donepezil-8-Hydroxyquinoline-2b
Assocoiates donepezil with clioquinol, which is able to chelate redox-active metals,thus decreasing metal-driven oxidative phenomena and beta-amyloid-mediated neurotoxicity
General
Type : Quinoline, Multitarget, Antioxidant, Derivative of Donepezil
Chemical_Nomenclature : 7-((4-(2-methoxybenzyl)piperazin-1-yl)methyl)-8-hydroxyquinoline
Canonical SMILES : COC1=CC=CC=C1CN2CCN(CC2)CC4=C(C3=C(C=CC=N3)C=C4)O
InChI : InChI=1S\/C22H25N3O2\/c1-27-20-7-3-2-5-18(20)15-24-11-13-25(14-12-24)16-19-9-8-17-6-4-10-23-21(17)22(19)26\/h2-10,26H,11-16H2,1H3
InChIKey : KIPWPJKDRADIRK-UHFFFAOYSA-N
Other name(s) : CHEMBL4082964
MW : 363.45
Formula : C22H25N3O2
CAS_number :
PubChem : 137645336
UniChem : KIPWPJKDRADIRK-UHFFFAOYSA-N
Target
Families : Donepezil-8-Hydroxyquinoline-2b ligand of proteins in family
BCHE
References (1)
| Title : Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease - Prati_2016_ChemMedChem_11_1284 |
| Author(s) : Prati F , Bergamini C , Fato R , Soukup O , Korabecny J , Andrisano V , Bartolini M , Bolognesi ML |
| Ref : ChemMedChem , 11 :1284 , 2016 |
| Abstract : |
| PubMedSearch : Prati_2016_ChemMedChem_11_1284 |
| PubMedID: 26880501 |