Ethoxy-trifluoromethylbenzoyl-hydrazine-idene-methyl-phenyl-difluorobenzenesulfonate-Cpd5i
IC50 11.29 +/- 0.98 nM AChE; IC50 1.12 +/- 0.41 nM BChE; IC50 102.70 +/- 5.26 nM for MAO-A
General
Type : Hydrazide, Sulfur Compound, Sulfonyl, Trifluoro, Monoamine-oxidase-inhibitor, Multitarget
Chemical_Nomenclature : (E)-2-Ethoxy-6-((2-(4-(trifluoromethyl)benzoyl)hydrazineylidene)methyl)phenyl-3,5-difluorobenzenesulfonate
Canonical SMILES : CCOC1=CC=CC(=C1O[S](C2=CC(=CC(=C2)F)F)(=O)=O)C=NNC(C3=CC=C(C=C3)C(F)(F)F)=O
InChI : InChI=1S\/C23H17F5N2O5S\/c1-2-34-20-5-3-4-15(21(20)35-36(32,33)19-11-17(24)10-18(25)12-19)13-29-30-22(31)14-6-8-16(9-7-14)23(26,27)28\/h3-13H,2H2,1H3,(H,30,31)
InChIKey : FNJCEUPIMGNMHX-UHFFFAOYSA-N
Other name(s) : Compound 5i
Target
Families : Ethoxy-trifluoromethylbenzoyl-hydrazine-idene-methyl-phenyl-difluorobenzenesulfonate-Cpd5i ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Synthesis, cholinesterase\/MAO-A inhibition, antioxidant potential and detailed computational analysis of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones - Fatima_2026_RSC.Adv_16_23987 |
| Author(s) : Fatima A , Noreen F , Senol H , Taslimi P , Ismail MA , Alharthy RD , Rasool A , Zaki MEA , Gomha SM , Shafiq Z |
| Ref : RSC Adv , 16 :23987 , 2026 |
| Abstract : |
| PubMedSearch : Fatima_2026_RSC.Adv_16_23987 |
| PubMedID: 42111529 |