FP9
EPHX2 IC50 = 0.2 nM
General
Type : Pyridazine, Urea derivative, Trifluoro
Chemical_Nomenclature : 1-(4-(6-Oxo-1,6-dihydropyridazin-3-yl) phenyl)-3-(2 (trifluoromethoxy) benzyl) urea
Canonical SMILES : C1(=CC=C(C=C1)NC(NCC2=CC=CC=C2OC(F)(F)F)=O)C3=NNC(C=C3)=O
InChI : InChI=1S\/C19H15F3N4O3\/c20-19(21,22)29-16-4-2-1-3-13(16)11-23-18(28)24-14-7-5-12(6-8-14)15-9-10-17(27)26-25-15\/h1-10H,11H2,(H,26,27)(H2,23,24,28)
InChIKey : ROVJOANYXCUXRN-UHFFFAOYSA-N
Other name(s) :
Target
Families : FP9 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Phenyl-benzyl-ureas with pyridazinone motif: Potent soluble epoxide hydrolase inhibitors with enhanced pharmacokinetics and efficacy in a paclitaxel-induced neuropathic pain model - Lengerli_2025_Eur.J.Med.Chem_290_117510 |
| Author(s) : Lengerli D , Bakht A , Caliskan K , Dahlke P , Bal NB , Jordan PM , Caliskan B , Werz O , Banoglu E |
| Ref : Eur Journal of Medicinal Chemistry , 290 :117510 , 2025 |
| Abstract : |
| PubMedSearch : Lengerli_2025_Eur.J.Med.Chem_290_117510 |
| PubMedID: 40101448 |
| Gene_locus related to this paper: human-EPHX2 |