Ferulic-Acid-Piperazine-Cpd13a
Anti Abeta1-42 aggregation in various AD models. 13a exhibited promising anticholinesterase activity against AChE (IC50 = 0.59 +/- 0.19 microM) and BChE (IC50 = 5.02 +/- 0.14 microM) with excellent antioxidant properties
General
Type : Multitarget, Piperazin, Quinoline, Feruloyl, Metal ion chelator, anti-Abeta-aggregation, Antioxidant
Chemical_Nomenclature : (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-((8-hydroxyquinolin-5-yl)methyl) piperazin-1-yl)prop-2-en-1-one
Canonical SMILES : C1(=CC=C(C=C1OC)C=CC(N2CCN(CC2)CC3=C4C(=C(C=C3)O)N=CC=C4)=O)O
InChI : InChI=1S\/C24H25N3O4\/c1-31-22-15-17(4-7-20(22)28)5-9-23(30)27-13-11-26(12-14-27)16-18-6-8-21(29)24-19(18)3-2-10-25-24\/h2-10,15,28-29H,11-14,16H2,1H3
InChIKey : UJBNEBCVKAXVMM-UHFFFAOYSA-N
Other name(s) : Compound 13a
Target
Families : Ferulic-Acid-Piperazine-Cpd13a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease - Singh_2024_ACS.Chem.Neurosci_15_2756 |
| Author(s) : Singh G , Kumar S , Panda SR , Kumar P , Rai S , Verma H , Singh YP , Srikrishna S , Naidu VGM , Modi G |
| Ref : ACS Chem Neurosci , 15 :2756 , 2024 |
| Abstract : |
| PubMedSearch : Singh_2024_ACS.Chem.Neurosci_15_2756 |
| PubMedID: 39076038 |