Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12
E12 IC50 microM AChE 0.156 +/- 0.11; BChE 5.74 +/- 1.9; MAO-A 19.7 +/- 2.2; MAO-B 54.9 +/- 2.7 with anti-Abeta/Tau and neuroprotective activities
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Piperazine, Carboxamide, Chromen, Coumarin, anti-Abeta-aggregation, anti-tau-aggregation
Chemical_Nomenclature : 6-Fluoro-N-(4-(4-methylpiperazin-1-yl)phenyl)-4-oxo-4H-chromene-2-carboxamide
Canonical SMILES : C1(=CC=C(C=C1)NC(C2=CC(C3=C(O2)C=CC(=C3)F)=O)=O)N4CC[N+](CC4)C
InChI : InChI=1S\/C21H20FN3O3\/c1-24-8-10-25(11-9-24)16-5-3-15(4-6-16)23-21(27)20-13-18(26)17-12-14(22)2-7-19(17)28-20\/h2-7,12-13H,8-11H2,1H3,(H,23,27)\/p+1
InChIKey : KHEZCYFTTUDDEB-UHFFFAOYSA-O
Other name(s) : Compound E12
Target
Families : Fluoro-methylpiperazin-phenyl-oxo-chromene-carboxamide-CpdE12 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Multi-target-directed chromone-carboxamide hybrids: Potent AChE\/MAO-B inhibitors with anti-Abeta\/Tau and neuroprotective activities - Lu_2026_Eur.J.Med.Chem_308_118701 |
| Author(s) : Lu J , Zhao C , Qiu Y , Xing Z , Shen LQ , Zhang M , Zhu H |
| Ref : Eur Journal of Medicinal Chemistry , 308 :118701 , 2026 |
| Abstract : |
| PubMedSearch : Lu_2026_Eur.J.Med.Chem_308_118701 |
| PubMedID: 41722429 |
| Title : Multi-target-directed chromone-carboxamide hybrids: Potent AChE\/MAO-B inhibitors with anti-Abeta\/Tau and neuroprotective activities - Lu_2026_Eur.J.Med.Chem_308_118701 |
| Author(s) : Lu J , Zhao C , Qiu Y , Xing Z , Shen LQ , Zhang M , Zhu H |
| Ref : Eur Journal of Medicinal Chemistry , 308 :118701 , 2026 |
| Abstract : |
| PubMedSearch : Lu_2026_Eur.J.Med.Chem_308_118701 |
| PubMedID: 41722429 |
| Title : Multi-target-directed chromone-carboxamide hybrids: Potent AChE\/MAO-B inhibitors with anti-Abeta\/Tau and neuroprotective activities - Lu_2026_Eur.J.Med.Chem_308_118701 |
| Author(s) : Lu J , Zhao C , Qiu Y , Xing Z , Shen LQ , Zhang M , Zhu H |
| Ref : Eur Journal of Medicinal Chemistry , 308 :118701 , 2026 |
| Abstract : |
| PubMedSearch : Lu_2026_Eur.J.Med.Chem_308_118701 |
| PubMedID: 41722429 |