Fluorobenzyl-methylaminoethyl-pyridin-quinoline-carboxamide-cpd6j
eeAChE IC50 >50 microM; eqBChE IC50 0.20 +/- 0.09 microM
General
Type : Pyridine, Quinoline, Carboxamide
Chemical_Nomenclature : N-(2-((4-fluorobenzyl)(methyl)amino)ethyl)-2-(pyridin-2-yl)quinoline-4-carboxamide
Canonical SMILES : C1=CC=C2C(=C1)C(=CC(=N2)C3=NC=CC=C3)C(=O)NCCN(CC4=CC=C(C=C4)F)C
InChI : InChI=1S\/C25H23FN4O\/c1-30(17-18-9-11-19(26)12-10-18)15-14-28-25(31)21-16-24(23-8-4-5-13-27-23)29-22-7-3-2-6-20(21)22\/h2-13,16H,14-15,17H2,1H3,(H,28,31)
InChIKey : WGRBBROXOHUBBN-UHFFFAOYSA-N
Other name(s) : Compound 6j
Target
Families : Fluorobenzyl-methylaminoethyl-pyridin-quinoline-carboxamide-cpd6j ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Virtual screening, structural optimization, computational studies, and biological evaluation of quinoline derivatives as selective butyrylcholinesterase inhibitors - Gao_2026_Bioorg.Chem_183_110617 |
| Author(s) : Gao H , Li F , Liu Q , Yin J , Xue Y , Xiao J , Tang Z , Liu C , Zhou X , Zhang X , Zheng Q , Liang D |
| Ref : Bioorg Chem , 183 :110617 , 2026 |
| Abstract : |
| PubMedSearch : Gao_2026_Bioorg.Chem_183_110617 |
| PubMedID: 42837740 |