Not inhibitor of Notum. Compound 15 Fragment 173 IC50 17+/-0.9 microM
Type : Fragment inhibitor of Notum, Benzimidazole, Cyanide
Chemical_Nomenclature : 1H-benzimidazol-2-ylcyanamide
Canonical SMILES : C1=CC=C2C(=C1)NC(=N2)NC#N
InChI : InChI=1S\/C8H6N4\/c9-5-10-8-11-6-3-1-2-4-7(6)12-8\/h1-4H,(H2,10,11,12)
InChIKey : NYLIXUBOFQIMGV-UHFFFAOYSA-N
Other name(s) : Fragment 173 || Compound 15 || AXV || 1H-benzimidazol-2-ylcyanamide || Cyanamide, 1H-benzimidazol-2-yl- || Cyanamide, 1H-benzimidazol-2-yl- (9CI) || Oprea1_539841 || SCHEMBL9247170 || ZINC394716
MW : 158.16
Formula : C8H6N4
CAS_number : 55864-37-4, 104145-05-3
PubChem : 96685
UniChem : NYLIXUBOFQIMGV-UHFFFAOYSA-N
Families : Fragment-173 ligand of proteins in family
Pectinacetylesterase-Notum
Structure :
7B8K
Protein :
human-NOTUM
Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
Abstract : |
PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
PubMedID: 35731924 |
Gene_locus related to this paper: human-NOTUM |