Itopride
Itopride is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions
General
Type : Not A\/B H target, Drug, Carboxamide, Dopamine antagonist, Benzamide
Chemical_Nomenclature : N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide
Canonical SMILES : CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC
InChI : InChI=1S\/C20H26N2O4\/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4\/h5-10,13H,11-12,14H2,1-4H3,(H,21,23)
InChIKey : QQQIECGTIMUVDS-UHFFFAOYSA-N
Other name(s) : SCHEMBL311309 || CHEMBL2107457 || CHEBI:94809 || DB04924
MW : 358.4
Formula : C20H26N2O4
CAS_number : 122898-67-3
PubChem : 3792
UniChem : QQQIECGTIMUVDS-UHFFFAOYSA-N
Target
Families : Itopride ligand of proteins in family
ACHE
Protein :
human-ACHE
References (9)
| Title : Efficacy and safety of itopride SR for upper gastrointestinal symptoms in patients with diabetic gastroparesis: real-world evidence from Pakistan - Ramzan_2023_Drugs.Context_12_ |
| Author(s) : Ramzan A , Memon GF , Shaikh AA , Khoso MM , Meher T , Ghafoor A , Shehzad NA , Ahmed S , Nawaz Z , Rehan M , Saeed T , Taj W , Abbass S , Khan R , Ehsan H , Alam A , Manzoor B , Khan MN , Yahya KM , Mukhtiar F , Javed MA , Sheikh MU , Janjua D , Jabeen S , Zafar J , Khokhar RH , Nazar M , Maheshwary N , Khan MA |
| Ref : Drugs Context , 12 : , 2023 |
| Abstract : |
| PubMedSearch : Ramzan_2023_Drugs.Context_12_ |
| PubMedID: 38148829 |
| Title : A double-blind randomized, multicenter, placebo-controlled study of itopride in functional dyspepsia postprandial distress syndrome - Carbone_2022_Neurogastroenterol.Motil__e14337 |
| Author(s) : Carbone F , Vandenberghe A , Holvoet L , Piessevaux H , Arts J , Caenepeel P , Staessen D , Vergauwe P , Maldague P , De Ronde T , Wuestenberghs F , Lamy V , Lefebvre V , Latour P , Vanuytsel T , Jones M , Tack J |
| Ref : Neurogastroenterol Motil , :e14337 , 2022 |
| Abstract : |
| PubMedSearch : Carbone_2022_Neurogastroenterol.Motil__e14337 |
| PubMedID: 35357058 |
| Title : Influence of itopride and domperidone on gastric tone and on the perception of gastric distention in healthy subjects - Van den Houte_2019_Neurogastroenterol.Motil__e13544 |
| Author(s) : Van den Houte K , Carbone F , Pauwels A , Vos R , Vanuytsel T , Tack J |
| Ref : Neurogastroenterol Motil , :e13544 , 2019 |
| Abstract : |
| PubMedSearch : Van den Houte_2019_Neurogastroenterol.Motil__e13544 |
| PubMedID: 30706652 |
| Title : The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man - Scarpellini_2011_Aliment.Pharmacol.Ther_33_99 |
| Author(s) : Scarpellini E , Vos R , Blondeau K , Boecxstaens V , Farre R , Gasbarrini A , Tack J |
| Ref : Aliment Pharmacol Ther , 33 :99 , 2011 |
| Abstract : |
| PubMedSearch : Scarpellini_2011_Aliment.Pharmacol.Ther_33_99 |
| PubMedID: 21083582 |
| Title : Pharmacokinetics and bioequivalence study of a fixed dose combination of rabeprazole and itopride in healthy Indian volunteers - Sahoo_2009_Arzneimittelforschung_59_451 |
| Author(s) : Sahoo BK , Das A , Agarwal S , Bhaumik U , Bose A , Ghosh D , Roy B , Pal TK |
| Ref : Arzneimittelforschung , 59 :451 , 2009 |
| Abstract : |
| PubMedSearch : Sahoo_2009_Arzneimittelforschung_59_451 |
| PubMedID: 19856792 |
| Title : Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro - Lim_2008_Yonsei.Med.J_49_472 |
| Author(s) : Lim HC , Kim YG , Lim JH , Kim HS , Park H |
| Ref : Yonsei Med J , 49 :472 , 2008 |
| Abstract : |
| PubMedSearch : Lim_2008_Yonsei.Med.J_49_472 |
| PubMedID: 18581598 |
| Title : A double-blind, randomized, placebo-controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers - Choung_2007_Neurogastroenterol.Motil_19_180 |
| Author(s) : Choung RS , Talley NJ , Peterson J , Camilleri M , Burton D , Harmsen WS , Zinsmeister AR |
| Ref : Neurogastroenterol Motil , 19 :180 , 2007 |
| Abstract : |
| PubMedSearch : Choung_2007_Neurogastroenterol.Motil_19_180 |
| PubMedID: 17300287 |
| Title : A placebo-controlled trial of itopride in functional dyspepsia - Holtmann_2006_N.Engl.J.Med_354_832 |
| Author(s) : Holtmann G , Talley NJ , Liebregts T , Adam B , Parow C |
| Ref : N Engl J Med , 354 :832 , 2006 |
| Abstract : |
| PubMedSearch : Holtmann_2006_N.Engl.J.Med_354_832 |
| PubMedID: 16495395 |
| Title : Characterization of acetylcholinesterase-inhibition by itopride - Iwanaga_1994_Jpn.J.Pharmacol_66_317 |
| Author(s) : Iwanaga Y , Kimura T , Miyashita N , Morikawa K , Nagata O , Itoh Z , Kondo Y |
| Ref : Japanese Journal of Pharmacology , 66 :317 , 1994 |
| Abstract : |
| PubMedSearch : Iwanaga_1994_Jpn.J.Pharmacol_66_317 |
| PubMedID: 7869618 |