LP-914822
human-NOTUM IC50 3.0+/-0.5nM
General
Type : Pyrimidine, Sulfur Compound
Chemical_Nomenclature :
Canonical SMILES : C12=NC=N[C@H](C1C(=C(S2)C)Cl)SCC(=O)O
InChI : InChI=1S\/C9H9ClN2O2S2\/c1-4-7(10)6-8(15-2-5(13)14)11-3-12-9(6)16-4\/h3,6,8
InChIKey : KYIJTOQSZPHUPC-XDKWHASVSA-N
Other name(s) :
Target
Families : LP-914822 ligand of proteins in family
Pectinacetylesterase-Notum
Protein :
human-NOTUM
mouse-notum
References (4)
| Title : Small-molecule inhibitors of carboxylesterase Notum - Zhao_2021_Future.Med.Chem__ |
| Author(s) : Zhao Y , Jolly S , Benvegnu S , Jones EY , Fish PV |
| Ref : Future Med Chem , : , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_Future.Med.Chem__ |
| PubMedID: 33882714 |
| Gene_locus related to this paper: human-NOTUM |
| Title : NOTUM inhibition increases endocortical bone formation and bone strength - Brommage_2019_Bone.Res_7_2 |
| Author(s) : Brommage R , Liu J , Vogel P , Mseeh F , Thompson AY , Potter DG , Shadoan MK , Hansen GM , Jeter-Jones S , Cui J , Bright D , Bardenhagen JP , Doree DD , Moverare-Skrtic S , Nilsson KH , Henning P , Lerner UH , Ohlsson C , Sands AT , Tarver JE , Powell DR , Zambrowicz B , Liu Q |
| Ref : Bone Res , 7 :2 , 2019 |
| Abstract : |
| PubMedSearch : Brommage_2019_Bone.Res_7_2 |
| PubMedID: 30622831 |
| Gene_locus related to this paper: human-NOTUM |
| Title : An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent - Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| Author(s) : Willis NJ , Bayle ED , Papageorgiou G , Steadman D , Atkinson BN , Mahy W , Fish PV |
| Ref : Beilstein J Org Chem , 15 :2790 , 2019 |
| Abstract : |
| PubMedSearch : Willis_2019_Beilstein.J.Org.Chem_15_2790 |
| PubMedID: 31807213 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019 |
| Abstract : |
| PubMedSearch : Atkinson_2019_Bioorg.Med.Chem.Lett__126751 |
| PubMedID: 31862412 |
| Gene_locus related to this paper: human-NOTUM |