mouse-notum

Mus musculus (Mouse) Protein notum homolog

Comment

In animals Notum acts to modify heparan sulfate proteoglycans and thereby alters the extracellular gradient of Wg\/Wnt protein

Relationship

Family : Pectinacetylesterase-Notum

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MGGEVRVLLL LGLLHWVGGS EGRKTWRRRG QQPPQPPPPP PLPQRAEVEP GAGQPVESFP LDFTAVEGNM DSFMAQVKSL AQSLYPCSAQ QLNEDLRLHL LLNTSVTCND GSPAGYYLKE SKGSRRWLLF LEGGWYCFNR ENCDSRYSTM RRLMSSKDWP HTRTGTGILS SQPEENPHWW NANMVFIPYC SSDVWSGASP KSDKNEYAFM GSLIIQEVVR ELLGKGLSGA KVLLLAGSSA GGTGVLLNVD RVAELLEELG YPSIQVRGLA DSGWFLDNKQ YRRSDCIDTI NCAPTDAIRR GIRYWSGMVP ERCQRQFKEG EEWNCFFGYK VYPTLRCPVF VVQWLFDEAQ LTVDNVHLTG QPVQEGQWLY IQNLGRELRG TLKDVQASFA PACLSHEIII RSYWTDVQVK GTSLPRALHC WDRSFHDSHK ASKTPMKGCP FHLVDSCPWP HCNPSCPTIR DQFTGQEMNV AQFLMHMGFD VQTVAQQQGM EPSKLLGMLS NGN

References (7)

Title : Notum deletion from late-stage skeletal cells increases cortical bone formation and potentiates skeletal effects of sclerostin inhibition - Choi_2021_J.Bone.Miner.Res__
Author(s) : Choi RB , Bullock WA , Hoggatt AM , Horan DJ , Pemberton EZ , Hong JM , Zhang X , He X , Robling AG
Ref : J Bone Miner Res , : , 2021
PubMedID: 34223673
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : Osteocyte- and late Osteoblast-derived NOTUM Reduces Cortical Bone Mass in Mice - Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__
Author(s) : Nilsson KH , Henning P , El Shahawy M , Wu J , Koskela A , Tuukkanen J , Perret C , Lerner UH , Ohlsson C , Moverare-Skrtic S
Ref : American Journal of Physiology Endocrinol Metab , : , 2021
PubMedID: 33749332
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398
Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P
Ref : Nature , 571 :398 , 2019
PubMedID: 31292548
Gene_locus related to this paper: human-NOTUM , mouse-notum

Title : Dentin Dysplasia in Notum Knockout Mice - Vogel_2016_Vet.Pathol_53_853
Author(s) : Vogel P , Read RW , Hansen GM , Powell DR , Kantaputra PN , Zambrowicz B , Brommage R
Ref : Vet Pathol , 53 :853 , 2016
PubMedID: 26926082
Gene_locus related to this paper: mouse-notum

Title : Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum - Canal_2016_PLoS.One_11_e0150997
Author(s) : Canal F , Charawi S , Grimber G , Houbron C , Drouet V , Colnot S , Terris B , Cavard C , Perret C
Ref : PLoS ONE , 11 :e0150997 , 2016
PubMedID: 26974334
Gene_locus related to this paper: mouse-notum

Title : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) - Gerhard_2004_Genome.Res_14_2121
Author(s) : Gerhard DS , Wagner L , Feingold EA , Shenmen CM , Grouse LH , Schuler G , Klein SL , Old S , Rasooly R , Good P , Guyer M , Peck AM , Derge JG , Lipman D , Collins FS , Jang W , Sherry S , Feolo M , Misquitta L , Lee E , Rotmistrovsky K , Greenhut SF , Schaefer CF , Buetow K , Bonner TI , Haussler D , Kent J , Kiekhaus M , Furey T , Brent M , Prange C , Schreiber K , Shapiro N , Bhat NK , Hopkins RF , Hsie F , Driscoll T , Soares MB , Casavant TL , Scheetz TE , Brown-stein MJ , Usdin TB , Toshiyuki S , Carninci P , Piao Y , Dudekula DB , Ko MS , Kawakami K , Suzuki Y , Sugano S , Gruber CE , Smith MR , Simmons B , Moore T , Waterman R , Johnson SL , Ruan Y , Wei CL , Mathavan S , Gunaratne PH , Wu J , Garcia AM , Hulyk SW , Fuh E , Yuan Y , Sneed A , Kowis C , Hodgson A , Muzny DM , McPherson J , Gibbs RA , Fahey J , Helton E , Ketteman M , Madan A , Rodrigues S , Sanchez A , Whiting M , Madari A , Young AC , Wetherby KD , Granite SJ , Kwong PN , Brinkley CP , Pearson RL , Bouffard GG , Blakesly RW , Green ED , Dickson MC , Rodriguez AC , Grimwood J , Schmutz J , Myers RM , Butterfield YS , Griffith M , Griffith OL , Krzywinski MI , Liao N , Morin R , Palmquist D , Petrescu AS , Skalska U , Smailus DE , Stott JM , Schnerch A , Schein JE , Jones SJ , Holt RA , Baross A , Marra MA , Clifton S , Makowski KA , Bosak S , Malek J
Ref : Genome Res , 14 :2121 , 2004
PubMedID: 15489334
Gene_locus related to this paper: human-AFMID , human-CES4A , human-CES5A , human-NOTUM , human-SERAC1 , human-SERHL2 , human-TMEM53 , mouse-acot1 , mouse-adcl4 , mouse-Ces2f , mouse-Ces4a , mouse-notum , mouse-q6wqj1 , mouse-Q9DAI6 , mouse-rbbp9 , mouse-SERHL , mouse-srac1 , mouse-tmm53 , rat-abhd6 , rat-abhda , rat-abhea , rat-abheb , rat-Ldah , rat-cd029 , rat-estd , rat-Kansl3 , rat-nceh1 , ratno-acph , ratno-CMBL , mouse-b2rwd2 , rat-b5den3 , rat-ab17c