Mus musculus (Mouse) Protein notum homolog
In animals Notum acts to modify heparan sulfate proteoglycans and thereby alters the extracellular gradient of Wg\/Wnt protein
Family : Pectinacetylesterase-Notum
Block : X
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMGGEVRVLLL LGLLHWVGGS EGRKTWRRRG QQPPQPPPPP PLPQRAEVEP GAGQPVESFP LDFTAVEGNM DSFMAQVKSL AQSLYPCSAQ QLNEDLRLHL LLNTSVTCND GSPAGYYLKE SKGSRRWLLF LEGGWYCFNR ENCDSRYSTM RRLMSSKDWP HTRTGTGILS SQPEENPHWW NANMVFIPYC SSDVWSGASP KSDKNEYAFM GSLIIQEVVR ELLGKGLSGA KVLLLAGSSA GGTGVLLNVD RVAELLEELG YPSIQVRGLA DSGWFLDNKQ YRRSDCIDTI NCAPTDAIRR GIRYWSGMVP ERCQRQFKEG EEWNCFFGYK VYPTLRCPVF VVQWLFDEAQ LTVDNVHLTG QPVQEGQWLY IQNLGRELRG TLKDVQASFA PACLSHEIII RSYWTDVQVK GTSLPRALHC WDRSFHDSHK ASKTPMKGCP FHLVDSCPWP HCNPSCPTIR DQFTGQEMNV AQFLMHMGFD VQTVAQQQGM EPSKLLGMLS NGN
| Title : Notum deletion from late-stage skeletal cells increases cortical bone formation and potentiates skeletal effects of sclerostin inhibition - Choi_2021_J.Bone.Miner.Res__ |
| Author(s) : Choi RB , Bullock WA , Hoggatt AM , Horan DJ , Pemberton EZ , Hong JM , Zhang X , He X , Robling AG |
| Ref : J Bone Miner Res , : , 2021 |
| Abstract : |
| PubMedSearch : Choi_2021_J.Bone.Miner.Res__ |
| PubMedID: 34223673 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Osteocyte- and late Osteoblast-derived NOTUM Reduces Cortical Bone Mass in Mice - Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__ |
| Author(s) : Nilsson KH , Henning P , El Shahawy M , Wu J , Koskela A , Tuukkanen J , Perret C , Lerner UH , Ohlsson C , Moverare-Skrtic S |
| Ref : American Journal of Physiology Endocrinol Metab , : , 2021 |
| Abstract : |
| PubMedSearch : Nilsson_2021_Am.J.Physiol.Endocrinol.Metab__ |
| PubMedID: 33749332 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398 |
| Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P |
| Ref : Nature , 571 :398 , 2019 |
| Abstract : |
| PubMedSearch : Pentinmikko_2019_Nature_571_398 |
| PubMedID: 31292548 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Dentin Dysplasia in Notum Knockout Mice - Vogel_2016_Vet.Pathol_53_853 |
| Author(s) : Vogel P , Read RW , Hansen GM , Powell DR , Kantaputra PN , Zambrowicz B , Brommage R |
| Ref : Vet Pathol , 53 :853 , 2016 |
| Abstract : |
| PubMedSearch : Vogel_2016_Vet.Pathol_53_853 |
| PubMedID: 26926082 |
| Gene_locus related to this paper: mouse-notum |
| Title : Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum - Canal_2016_PLoS.One_11_e0150997 |
| Author(s) : Canal F , Charawi S , Grimber G , Houbron C , Drouet V , Colnot S , Terris B , Cavard C , Perret C |
| Ref : PLoS ONE , 11 :e0150997 , 2016 |
| Abstract : |
| PubMedSearch : Canal_2016_PLoS.One_11_e0150997 |
| PubMedID: 26974334 |
| Gene_locus related to this paper: mouse-notum |