LY36
General
Type : Fluorescent Probe, Phenalen, Piperidine, Indole, Benzylpiperidine, Derivative of Donepezil
Chemical_Nomenclature : N-[2-(1-benzylpiperidin-4-yl)ethyl]-(2S)-2-{6-[6-(dimethylamino)-1,3-dioxo-2-aza-3H-phenalen-2(1H)-yl]hexylamino}-3-(1H-indol-3-yl)propanamide
Canonical SMILES : C6(=CC=C1C7=C(C(N(C1=O)CCCCCCN[C@H](C(NCCC2CCN(CC2)CC3=CC=CC=C3)=O)CC4=C[N]C5=C4C=CC=C5)=O)C=CC=C67)N(C)C
InChI : InChI=1S\/C45H54N6O3\/c1-49(2)41-20-19-38-42-36(41)16-12-17-37(42)44(53)51(45(38)54)26-11-4-3-10-24-46-40(29-34-30-48-39-18-9-8-15-35(34)39)43(52)47-25-21-32-22-27-50(28-23-32)31-33-13-6-5-7-14-33\/h5-9,12-20,30,32,40,46,48H,3-4,10-11,21-29,31H2,1-2H3,(H,47,52)\/t40-\/m0\/s1
InChIKey : YMPLCHUPFFOLCO-FAIXQHPJSA-N
Other name(s) : N-[2-(1-Benzyl-4-piperidyl)ethyl](S)-2-{6-[6-(dimethylamino)-1,3-dioxo-2-aza-2,3-dihydro-1H-phenalen-2-yl]hexylamino}-3-(3-indolyl)propionamide
Target
Families : LY36 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's disease - Guo_2026_RSC.Med.Chem__ |
| Author(s) : Guo N , Wang F , Wang Y , Du J , Zhang Q , Cao W , Su J , Zhao F , Wang J , Pang X , Zhou Y , Yan L |
| Ref : RSC Med Chem , : , 2026 |
| Abstract : |
| PubMedSearch : Guo_2026_RSC.Med.Chem__ |
| PubMedID: 42318373 |