MHH

Inhibition by Methyl 4-nitrophenyl hexylphosphonate 6RB0 gives the same adduct MHH (methyl hydrogen (R)-hexylphosphonate) on the active serine as 4-methylumbelliferyl-hexylphosphonate 3ICW

General

Type : Organophosphate, pNP

Chemical_Nomenclature : hexyl(methoxy)phosphinic acid

Canonical SMILES : CCCCCCP(=O)(O)OC

InChI : InChI=1S\/C7H17O3P\/c1-3-4-5-6-7-11(8,9)10-2\/h3-7H2,1-2H3,(H,8,9)

InChIKey : FOQQOPHBXMFLMD-UHFFFAOYSA-N

Other name(s) : Methyl Hydrogen (R)-Hexylphosphonate  ||  SCHEMBL14883684  ||  Q27463148


MW : 180.18

Formula : C7H17O3P

CAS_number :

PubChem : 20196937

UniChem : FOQQOPHBXMFLMD-UHFFFAOYSA-N

Target

Families : MHH ligand of proteins in family
Hormone-sensitive_lipase_like

Structure :
6RB0

Protein :
9bact-LAE6

References (1)

Title : Genetically engineered proteins with two active sites for enhanced biocatalysis and synergistic chemo- and biocatalysis - Alonso_2020_Nat.Catal_3_319
Author(s) : Alonso S , Santiago G , Cea-Rama I , Fernandez-Lopez L , Coscolin C , Modregger J , Ressmann A , Martinez-Martinez M , Marrero H , Bargiela R , Pita M , Gonzalez-Alfonso JL , Briand M , Rojo D , Barbas C , Plou FJ , Golyshin PN , Shahgaldian P , Sanz-Aparicio J , Guallar V , Ferrer M
Ref : Nature Catalysis , 3 :319 , 2019
Abstract :
PubMedSearch : Alonso_2020_Nat.Catal_3_319
PubMedID:
Gene_locus related to this paper: 9bact-LAE6