N-benzylpiperidine-carbazol-9c
IC50 = 26.5 microM for AChE and IC50 = 0.18 microM for BuChE
General
Type : Piperidine, Carbazol, Derivative of Donepezil, Multitarget
Chemical_Nomenclature : TN-(6-(9H-carbazol-9-yl) hexyl)-1-benzylpiperidin-4-amine
Canonical SMILES : C1=CC(=CC=C1)CN2CCC(CC2)NCCCCCC[N]3C5=C(C4=C3C=CC=C4)C=CC=C5
InChI : InChI=1S\/C30H37N3\/c1(10-20-31-26-18-22-32(23-19-26)24-25-12-4-3-5-13-25)2-11-21-33-29-16-8-6-14-27(29)28-15-7-9-17-30(28)33\/h3-9,12-17,26,31H,1-2,10-11,18-24H2
InChIKey : ZBPJIEQJMNSVBM-UHFFFAOYSA-N
Other name(s) : 9c
Target
Families : N-benzylpiperidine-carbazol-9c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Design, synthesis and biological activity evaluation of novel carbazole-benzylpiperidine hybrids as potential anti Alzheimer agents - Sadeghian_2020_J.Mol.Struct_1221_128793 |
| Author(s) : Sadeghian B , Sakhteman A , Faghih Z , Nadri H , Edraki N , Iraji A , Sadeghian I , Rezaei Z |
| Ref : J Mol Struct , 12211 :128793 , 2020 |
| Abstract : |
| PubMedSearch : Sadeghian_2020_J.Mol.Struct_1221_128793 |
| PubMedID: |